ORBIMED ADVISORS LLC Diversified Active

CIK: 0001055951 · Show all filings

Period: Q2 2018 (← Previous) (Next →)

Filing Date: Aug 14, 2018

Total Value ($000): $8,384,406 (99.4% shares, 0.6% debt)

Holdings (147)

ALEXION PHARMACEUTICALS INC 4.6%
Value ($000) $387,919 Shares 3,124,603 Est. Cost $137.22 Unrealized
BIIB BIOGEN INC 4.0%
Value ($000) $338,971 Shares 1,167,900 Est. Cost $265.33 Unrealized +6.0%
TRICIDA INC 3.9%
Value ($000) $325,589 Shares 10,889,280 Est. Cost $29.90 Unrealized
BSX BOSTON SCIENTIFIC CORP 3.7%
Value ($000) $313,093 Shares 9,574,695 Est. Cost $16.76 Unrealized +80.0%
VRTX VERTEX PHARMACEUTICALS INC 3.6%
Value ($000) $304,670 Shares 1,792,600 Est. Cost $99.02 Unrealized +56.5%
ASND ASCENDIS PHARMA A S 3.5%
Value ($000) $293,572 Shares 4,413,291 Est. Cost $29.06 Unrealized
MRK MERCK & CO INC 3.4%
Value ($000) $284,076 Shares 4,680,000 Est. Cost $42.56 Unrealized +4.6%
ALLERGAN PLC 2.6%
Value ($000) $214,436 Shares 1,286,205 Est. Cost $197.01 Unrealized
CELGENE CORP 2.4%
Value ($000) $204,161 Shares 2,570,650 Est. Cost $110.05 Unrealized
JAZZ JAZZ PHARMACEUTICALS PLC 2.1%
Value ($000) $179,209 Shares 1,040,100 Est. Cost $138.48 Unrealized +18.0%
WRIGHT MED GROUP N V 2.0%
Value ($000) $164,136 Shares 6,322,668 Est. Cost $25.17 Unrealized
PBYI PUMA BIOTECHNOLOGY INC 1.9%
Value ($000) $161,650 Shares 2,732,881 Est. Cost $89.74 Unrealized -35.4%
CLEMENTIA PHARMACEUTICALS IN 1.6%
Value ($000) $137,196 Shares 10,425,225 Est. Cost $16.89 Unrealized
MYLAN N V 1.6%
Value ($000) $133,819 Shares 3,702,800 Est. Cost $36.86 Unrealized
BMY BRISTOL MYERS SQUIBB CO 1.6%
Value ($000) $131,726 Shares 2,380,300 Est. Cost $45.67 Unrealized -11.0%
REGN REGENERON PHARMACEUTICALS 1.5%
Value ($000) $128,509 Shares 372,500 Est. Cost $376.21 Unrealized -17.3%
AERIE PHARMACEUTICALS INC 1.5%
Value ($000) $127,271 Shares 1,884,100 Est. Cost $44.54 Unrealized
EW EDWARDS LIFESCIENCES CORP 1.5%
Value ($000) $126,777 Shares 870,900 Est. Cost $34.62 Unrealized +34.8%
ELV ANTHEM INC 1.5%
Value ($000) $126,584 Shares 531,800 Est. Cost $209.44 Unrealized 0.0%
ALNY ALNYLAM PHARMACEUTICALS INC 1.5%
Value ($000) $124,685 Shares 1,265,966 Est. Cost $86.12 Unrealized +15.2%
TMO THERMO FISHER SCIENTIFIC INC 1.4%
Value ($000) $120,866 Shares 583,500 Est. Cost $131.01 Unrealized +58.8%
DVA DAVITA INC 1.4%
Value ($000) $117,312 Shares 1,689,400 Est. Cost $69.57 Unrealized -4.0%
IMMUNOMEDICS INC 1.4%
Value ($000) $117,038 Shares 4,944,573 Est. Cost $10.59 Unrealized
A AGILENT TECHNOLOGIES INC 1.4%
Value ($000) $116,575 Shares 1,885,100 Est. Cost $36.59 Unrealized +68.6%
FOLD AMICUS THERAPEUTICS INC 1.3%
Value ($000) $110,472 Shares 7,072,500 Est. Cost $14.05 Unrealized +7.6%
CLOVIS ONCOLOGY INC 1.3%
Value ($000) $105,985 Shares 2,330,870 Est. Cost $86.21 Unrealized
XRAY DENTSPLY SIRONA INC 1.2%
Value ($000) $104,763 Shares 2,393,500 Est. Cost $48.09 Unrealized -2.3%
NEVRO CORP 1.2%
Value ($000) $100,618 Shares 1,260,091 Est. Cost $77.98 Unrealized
AUDENTES THERAPEUTICS INC 1.2%
Value ($000) $99,919 Shares 2,615,000 Est. Cost $17.81 Unrealized
LOXO ONCOLOGY INC 1.1%
Value ($000) $93,332 Shares 538,000 Est. Cost $1.07 Unrealized
SEM SELECT MED HLDGS CORP 1.1%
Value ($000) $92,097 Shares 5,074,200 Est. Cost $7.32 Unrealized +23.5%
JNJ JOHNSON & JOHNSON 1.1%
Value ($000) $91,733 Shares 756,000 Est. Cost $90.07 Unrealized +11.8%
INSP INSPIRE MED SYS INC 1.0%
Value ($000) $87,161 Shares 2,444,221 Est. Cost $32.28 Unrealized 0.0%
ARRAY BIOPHARMA INC 1.0%
Value ($000) $82,237 Shares 4,900,900 Est. Cost $5.98 Unrealized
ILMN ILLUMINA INC 0.9%
Value ($000) $79,458 Shares 284,500 Est. Cost $123.96 Unrealized +105.2%
DECIPHERA PHARMACEUTICALS IN 0.9%
Value ($000) $78,924 Shares 2,005,700 Est. Cost $25.41 Unrealized
BLUEBIRD BIO INC 0.9%
Value ($000) $76,623 Shares 488,200 Est. Cost $127.27 Unrealized
IOVA IOVANCE BIOTHERAPEUTICS INC 0.8%
Value ($000) $71,019 Shares 5,548,326 Est. Cost $6.34 Unrealized +130.4%
INSM INSMED INC 0.8%
Value ($000) $69,245 Shares 2,927,891 Est. Cost $22.80 Unrealized +12.9%
CRVS CORVUS PHARMACEUTICALS INC 0.8%
Value ($000) $65,524 Shares 5,967,584 Est. Cost $13.85 Unrealized -19.4%
VRAYQ VIEWRAY INC 0.8%
Value ($000) $65,453 Shares 9,458,567 Est. Cost $4.68 Unrealized +55.2%
ACAD ACADIA PHARMACEUTICALS INC 0.8%
Value ($000) $65,392 Shares 4,282,400 Est. Cost $26.37 Unrealized -32.4%
RYTM RHYTHM PHARMACEUTICALS INC 0.8%
Value ($000) $64,552 Shares 2,065,000 Est. Cost $26.40 Unrealized +3.6%
SHIRE PLC 0.7%
Value ($000) $60,195 Shares 356,608 Est. Cost $166.25 Unrealized
SRPT SAREPTA THERAPEUTICS INC 0.7%
Value ($000) $59,825 Shares 452,600 Est. Cost $71.67 Unrealized +31.6%
IRWD IRONWOOD PHARMACEUTICALS INC 0.7%
Value ($000) $56,007 Shares 2,929,250 Est. Cost $10.99 Unrealized +34.6%
ISRG INTUITIVE SURGICAL INC 0.6%
Value ($000) $52,872 Shares 110,500 Est. Cost $104.83 Unrealized +45.5%
UHS UNIVERSAL HLTH SVCS INC 0.6%
Value ($000) $51,630 Shares 463,300 Est. Cost $113.26 Unrealized -0.0%
XTNT XTANT MED HLDGS INC 0.6%
Value ($000) $51,099 Shares 9,207,012 Est. Cost $6.59 Unrealized +1.5%
HRTX HERON THERAPEUTICS INC 0.6%
Value ($000) $51,092 Shares 1,315,100 Est. Cost $19.53 Unrealized +63.0%
TFX TELEFLEX INC 0.6%
Value ($000) $51,067 Shares 190,400 Est. Cost $253.19 Unrealized +1.3%
ARGX ARGENX SE 0.6%
Value ($000) $49,658 Shares 599,300 Est. Cost $31.42 Unrealized
KALA PHARMACEUTICALS INC 0.6%
Value ($000) $47,339 Shares 3,447,840 Est. Cost $20.66 Unrealized
GLPG GALAPAGOS NV 0.5%
Value ($000) $44,891 Shares 486,990 Est. Cost $76.76 Unrealized
RESTORBIO INC 0.5%
Value ($000) $44,198 Shares 4,830,387 Est. Cost $9.58 Unrealized
EHTH EHEALTH INC 0.5%
Value ($000) $40,547 Shares 1,834,700 Est. Cost $11.97 Unrealized +61.1%
ONC BEIGENE LTD 0.5%
Value ($000) $40,185 Shares 261,400 Est. Cost $36.10 Unrealized
OBSEVA SA 0.5%
Value ($000) $39,448 Shares 2,605,531 Est. Cost $10.41 Unrealized
ZLAB ZAI LAB LTD 0.4%
Value ($000) $37,456 Shares 1,611,000 Est. Cost $24.78 Unrealized
MD MEDNAX INC 0.4%
Value ($000) $37,333 Shares 862,600 Est. Cost $50.88 Unrealized -5.8%
TNDM TANDEM DIABETES CARE INC 0.4%
Value ($000) $37,192 Shares 1,689,000 Est. Cost $12.30 Unrealized 0.0%
CIGNA CORPORATION 0.4%
Value ($000) $36,505 Shares 214,800 Est. Cost $168.27 Unrealized
EXEL EXELIXIS INC 0.4%
Value ($000) $36,179 Shares 1,681,200 Est. Cost $20.68 Unrealized 0.0%
PFE PFIZER INC 0.4%
Value ($000) $35,627 Shares 982,000 Est. Cost $18.91 Unrealized +28.5%
UNH UNITEDHEALTH GROUP INC 0.4%
Value ($000) $30,250 Shares 123,300 Est. Cost $212.11 Unrealized 0.0%
VRTX VERTEX PHARMACEUTICALS INC 0.4%
Value ($000) $29,743 Shares 175,000 Est. Cost $99.02 Unrealized +56.5%
INCY INCYTE CORP 0.4%
Value ($000) $29,346 Shares 438,000 Est. Cost $68.39 Unrealized 0.0%
VERRICA PHARMACEUTICALS INC 0.3%
Value ($000) $29,195 Shares 1,479,733 Est. Cost $19.73 Unrealized
CRSP CRISPR THERAPEUTICS AG 0.3%
Value ($000) $29,157 Shares 496,200 Est. Cost $53.67 Unrealized +6.2%
ASSEMBLY BIOSCIENCES INC 0.3%
Value ($000) $28,277 Shares 721,166 Est. Cost $25.39 Unrealized
IMMUNOGEN INC 0.3%
Value ($000) $28,259 Shares 2,904,270 Est. Cost $10.29 Unrealized
GILD GILEAD SCIENCES INC 0.3%
Value ($000) $25,828 Shares 364,600 Est. Cost $50.75 Unrealized +3.9%
INSYS THERAPEUTICS INC NEW 0.3%
Value ($000) $25,424 Shares 3,511,544 Est. Cost $27.55 Unrealized
LIFEPOINT HEALTH INC 0.3%
Value ($000) $25,044 Shares 513,200 Est. Cost $47.00 Unrealized
ALPINE IMMUNE SCIENCES INC 0.3%
Value ($000) $24,970 Shares 3,298,516 Est. Cost $11.60 Unrealized
CTI BIOPHARMA CORP 0.3%
Value ($000) $24,900 Shares 5,000,000 Est. Cost $3.31 Unrealized
SELECTA BIOSCIENCES INC 0.3%
Value ($000) $24,417 Shares 1,842,797 Est. Cost $13.99 Unrealized
HCA HCA HEALTHCARE INC 0.3%
Value ($000) $24,347 Shares 237,300 Est. Cost $90.31 Unrealized +4.6%
INSMED INC 0.3%
Value ($000) $24,253 Shares 26,500,000 Est. Cost $0.89 Unrealized
SYK STRYKER CORP 0.3%
Value ($000) $24,215 Shares 143,400 Est. Cost $93.40 Unrealized +65.7%
MAGELLAN HEALTH INC 0.3%
Value ($000) $24,120 Shares 251,383 Est. Cost $64.56 Unrealized
ABT ABBOTT LABS 0.3%
Value ($000) $24,036 Shares 394,100 Est. Cost $52.58 Unrealized +1.1%
NTLA INTELLIA THERAPEUTICS INC 0.3%
Value ($000) $23,967 Shares 876,000 Est. Cost $26.61 Unrealized -8.9%
AMGN AMGEN INC 0.3%
Value ($000) $22,908 Shares 124,100 Est. Cost $86.91 Unrealized +61.4%
RADIUS HEALTH INC 0.3%
Value ($000) $22,483 Shares 762,900 Est. Cost $37.37 Unrealized
HUM HUMANA INC 0.3%
Value ($000) $21,608 Shares 72,600 Est. Cost $274.31 Unrealized 0.0%
AERPIO PHARMACEUTICALS INC 0.3%
Value ($000) $21,555 Shares 5,193,946 Est. Cost $4.15 Unrealized
SVA SINOVAC BIOTECH LTD 0.3%
Value ($000) $21,183 Shares 2,839,500 Est. Cost $4.60 Unrealized +71.1%
CHRS COHERUS BIOSCIENCES INC 0.2%
Value ($000) $20,727 Shares 1,480,482 Est. Cost $22.53 Unrealized -36.5%
FOAMIX PHARMACEUTICALS LTD 0.2%
Value ($000) $20,240 Shares 4,040,000 Est. Cost $5.04 Unrealized
GLOBAL BLOOD THERAPEUTICS IN 0.2%
Value ($000) $20,217 Shares 447,275 Est. Cost $32.00 Unrealized
SYNLOGIC INC 0.2%
Value ($000) $19,955 Shares 2,029,996 Est. Cost $15.62 Unrealized
AEGLEA BIOTHERAPEUTICS INC 0.2%
Value ($000) $19,737 Shares 1,865,524 Est. Cost $6.23 Unrealized
SCPHARMACEUTICALS INC 0.2%
Value ($000) $19,300 Shares 3,409,865 Est. Cost $12.09 Unrealized
STEADYMED LTD 0.2%
Value ($000) $19,108 Shares 4,246,196 Est. Cost $4.34 Unrealized
K2M GROUP HLDGS INC 0.2%
Value ($000) $18,972 Shares 843,205 Est. Cost $18.95 Unrealized
NTRA NATERA INC 0.2%
Value ($000) $18,520 Shares 984,086 Est. Cost $15.79 Unrealized -23.0%
NOVUS THERAPEUTICS INC 0.2%
Value ($000) $17,760 Shares 2,537,110 Est. Cost $5.85 Unrealized
VERONA PHARMA PLC 0.2%
Value ($000) $17,080 Shares 1,250,396 Est. Cost $11.76 Unrealized
PIERIS PHARMACEUTICALS INC 0.2%
Value ($000) $15,920 Shares 3,140,000 Est. Cost $2.75 Unrealized
NVO NOVO-NORDISK A S 0.2%
Value ($000) $15,220 Shares 330,000 Est. Cost $48.15 Unrealized
RCKT ROCKET PHARMACEUTICALS INC 0.2%
Value ($000) $15,213 Shares 775,000 Est. Cost $16.31 Unrealized +16.0%
AMEDISYS INC 0.2%
Value ($000) $14,622 Shares 171,100 Est. Cost $52.71 Unrealized
NABRIVA THERAPEUTICS PLC 0.2%
Value ($000) $13,640 Shares 3,919,600 Est. Cost $10.48 Unrealized
NBIX NEUROCRINE BIOSCIENCES INC 0.2%
Value ($000) $13,537 Shares 137,800 Est. Cost $86.76 Unrealized +3.2%
THC TENET HEALTHCARE CORP 0.1%
Value ($000) $12,518 Shares 372,900 Est. Cost $19.91 Unrealized +56.1%
TRIPLE-S MGMT CORP 0.1%
Value ($000) $11,359 Shares 290,800 Est. Cost $26.14 Unrealized
WRIGHT MED GROUP N V 0.1%
Value ($000) $11,196 Shares 8,746,583 Est. Cost $1.52 Unrealized
INVITAE CORP 0.1%
Value ($000) $11,159 Shares 1,518,197 Est. Cost $11.59 Unrealized
AEGERION PHARMACEUTICALS INC 0.1%
Value ($000) $9,718 Shares 15,000,000 Est. Cost $0.78 Unrealized
PRQR PROQR THRAPEUTICS N V 0.1%
Value ($000) $9,512 Shares 1,302,955 Est. Cost $14.69 Unrealized -65.7%
DERMIRA INC 0.1%
Value ($000) $9,491 Shares 1,031,596 Est. Cost $9.20 Unrealized
LAB FLUIDIGM CORP DEL 0.1%
Value ($000) $9,439 Shares 1,583,700 Est. Cost $23.26 Unrealized -75.5%
ALEXION PHARMACEUTICALS INC 0.1%
Value ($000) $8,691 Shares 70,000 Est. Cost $137.22 Unrealized
FLUIDIGM CORP DEL 0.1%
Value ($000) $8,093 Shares 10,000,000 Est. Cost $1.10 Unrealized
ATHENEX INC 0.1%
Value ($000) $8,024 Shares 430,000 Est. Cost $17.01 Unrealized
DBV TECHNOLOGIES S A 0.1%
Value ($000) $7,922 Shares 410,700 Est. Cost $34.68 Unrealized
ADAPY ADAPTIMMUNE THERAPEUTICS PLC 0.1%
Value ($000) $7,912 Shares 666,593 Est. Cost $7.98 Unrealized
INOTEK PHARMACEUTICALS CORP 0.1%
Value ($000) $7,214 Shares 7,000,000 Est. Cost $1.36 Unrealized
BMRN BIOMARIN PHARMACEUTICAL INC 0.1%
Value ($000) $7,206 Shares 76,500 Est. Cost $86.40 Unrealized +1.4%
AVROBIO INC 0.1%
Value ($000) $7,140 Shares 250,000 Est. Cost $28.56 Unrealized
ARSANIS INC 0.1%
Value ($000) $6,784 Shares 1,868,966 Est. Cost $12.76 Unrealized
BMRN BIOMARIN PHARMACEUTICAL INC 0.1%
Value ($000) $6,594 Shares 70,000 Est. Cost $86.40 Unrealized +1.4%
ELECTROCORE INC 0.1%
Value ($000) $6,568 Shares 397,826 Est. Cost $16.51 Unrealized
ALKS ALKERMES PLC 0.1%
Value ($000) $5,968 Shares 145,000 Est. Cost $56.71 Unrealized -19.7%
XENE XENON PHARMACEUTICALS INC 0.1%
Value ($000) $5,840 Shares 634,812 Est. Cost $7.72 Unrealized -19.6%
RARE ULTRAGENYX PHARMACEUTICAL IN 0.1%
Value ($000) $5,197 Shares 67,605 Est. Cost $64.59 Unrealized 0.0%
REDHILL BIOPHARMA LTD 0.1%
Value ($000) $4,819 Shares 564,900 Est. Cost $14.14 Unrealized
CLOVIS ONCOLOGY INC 0.1%
Value ($000) $4,547 Shares 100,000 Est. Cost $86.21 Unrealized
MARINUS PHARMACEUTICALS INC 0.0%
Value ($000) $4,013 Shares 567,600 Est. Cost $7.64 Unrealized
STIM NEURONETICS INC 0.0%
Value ($000) $3,992 Shares 150,000 Est. Cost $27.20 Unrealized 0.0%
SIERRA ONCOLOGY INC 0.0%
Value ($000) $3,751 Shares 1,267,104 Est. Cost $1.53 Unrealized
KIDS ORTHOPEDIATRICS CORP 0.0%
Value ($000) $3,647 Shares 136,900 Est. Cost $19.13 Unrealized +11.6%
AKORN INC 0.0%
Value ($000) $3,318 Shares 200,000 Est. Cost Unrealized
SNDX SYNDAX PHARMACEUTICALS INC 0.0%
Value ($000) $3,068 Shares 437,000 Est. Cost $12.54 Unrealized -21.8%
TESARO INC 0.0%
Value ($000) $2,992 Shares 67,281 Est. Cost $82.88 Unrealized
GW PHARMACEUTICALS PLC 0.0%
Value ($000) $2,930 Shares 21,000 Est. Cost $112.66 Unrealized
IRWD IRONWOOD PHARMACEUTICALS INC 0.0%
Value ($000) $2,868 Shares 150,000 Est. Cost $10.99 Unrealized +34.6%
ADAMAS PHARMACEUTICALS INC 0.0%
Value ($000) $2,583 Shares 100,000 Est. Cost Unrealized
AUPH AURINIA PHARMACEUTICALS INC 0.0%
Value ($000) $943 Shares 167,419 Est. Cost $4.62 Unrealized +20.8%
BIOLINERX LTD 0.0%
Value ($000) $924 Shares 1,038,600 Est. Cost $1.62 Unrealized
BIOMARIN PHARMACEUTICAL INC 0.0%
Value ($000) $592 Shares 500,000 Est. Cost $1.08 Unrealized
AFFIMED N V 0.0%
Value ($000) $539 Shares 326,650 Est. Cost $6.30 Unrealized
RECRO PHARMA INC 0.0%
Value ($000) $539 Shares 107,357 Est. Cost $5.02 Unrealized
BIOMARIN PHARMACEUTICAL INC 0.0%
Value ($000) $532 Shares 500,000 Est. Cost $1.07 Unrealized
ALIMERA SCIENCES INC 0.0%
Value ($000) $245 Shares 250,000 Est. Cost $7.89 Unrealized
MEDIGUS LTD 0.0%
Value ($000) $74 Shares 60,000 Est. Cost $3.08 Unrealized