ORBIMED ADVISORS LLC Diversified Active

CIK: 0001055951 · Show all filings

Period: Q3 2018 (← Previous) (Next →)

Filing Date: Nov 14, 2018

Total Value ($000): $8,302,401 (99.5% shares, 0.5% debt)

Holdings (150)

ALEXION PHARMACEUTICALS INC 4.8%
Value ($000) $400,502 Shares 2,881,103 Est. Cost $137.22 Unrealized
TRICIDA INC 4.0%
Value ($000) $332,668 Shares 10,889,280 Est. Cost $29.90 Unrealized
BIIB BIOGEN INC 3.9%
Value ($000) $321,618 Shares 910,300 Est. Cost $265.33 Unrealized +29.8%
VRTX VERTEX PHARMACEUTICALS INC 3.7%
Value ($000) $308,480 Shares 1,600,500 Est. Cost $99.02 Unrealized +79.8%
BSX BOSTON SCIENTIFIC CORP 3.6%
Value ($000) $302,764 Shares 7,863,995 Est. Cost $16.76 Unrealized +108.4%
ASND ASCENDIS PHARMA A S 3.5%
Value ($000) $294,486 Shares 4,155,891 Est. Cost $29.06 Unrealized
MRK MERCK & CO INC 3.0%
Value ($000) $251,440 Shares 3,544,400 Est. Cost $42.56 Unrealized +19.0%
CELGENE CORP 2.7%
Value ($000) $220,490 Shares 2,463,850 Est. Cost $110.05 Unrealized
ALLERGAN PLC 2.6%
Value ($000) $219,129 Shares 1,150,405 Est. Cost $197.01 Unrealized
WRIGHT MED GROUP N V 2.3%
Value ($000) $186,876 Shares 6,439,568 Est. Cost $25.24 Unrealized
MYLAN N V 2.1%
Value ($000) $174,933 Shares 4,779,600 Est. Cost $36.80 Unrealized
EW EDWARDS LIFESCIENCES CORP 2.1%
Value ($000) $172,463 Shares 990,600 Est. Cost $36.35 Unrealized +34.5%
TMO THERMO FISHER SCIENTIFIC INC 2.0%
Value ($000) $163,045 Shares 668,000 Est. Cost $142.98 Unrealized +57.8%
REGN REGENERON PHARMACEUTICALS 1.9%
Value ($000) $159,353 Shares 394,400 Est. Cost $376.34 Unrealized +0.6%
JAZZ JAZZ PHARMACEUTICALS PLC 1.8%
Value ($000) $148,627 Shares 884,000 Est. Cost $138.48 Unrealized +24.2%
SRPT SAREPTA THERAPEUTICS INC 1.7%
Value ($000) $137,994 Shares 854,400 Est. Cost $102.25 Unrealized +33.7%
HUM HUMANA INC 1.6%
Value ($000) $133,038 Shares 393,000 Est. Cost $299.22 Unrealized +1.9%
CIGNA CORPORATION 1.6%
Value ($000) $132,010 Shares 633,900 Est. Cost $194.70 Unrealized
ELV ANTHEM INC 1.6%
Value ($000) $129,900 Shares 474,000 Est. Cost $209.44 Unrealized +12.5%
BMY BRISTOL MYERS SQUIBB CO 1.5%
Value ($000) $125,762 Shares 2,025,800 Est. Cost $45.67 Unrealized -1.5%
PBYI PUMA BIOTECHNOLOGY INC 1.5%
Value ($000) $124,033 Shares 2,705,181 Est. Cost $89.74 Unrealized -46.3%
CLEMENTIA PHARMACEUTICALS IN 1.4%
Value ($000) $116,241 Shares 10,425,225 Est. Cost $16.89 Unrealized
DVA DAVITA INC 1.2%
Value ($000) $103,555 Shares 1,445,700 Est. Cost $69.57 Unrealized +1.6%
INSP INSPIRE MED SYS INC 1.2%
Value ($000) $102,853 Shares 2,444,221 Est. Cost $32.28 Unrealized +45.4%
ILMN ILLUMINA INC 1.2%
Value ($000) $98,189 Shares 267,500 Est. Cost $123.96 Unrealized +158.5%
IMMUNOMEDICS INC 1.1%
Value ($000) $90,164 Shares 4,328,573 Est. Cost $10.59 Unrealized
AUDENTES THERAPEUTICS INC 1.0%
Value ($000) $86,306 Shares 2,180,000 Est. Cost $17.81 Unrealized
NEVRO CORP 0.9%
Value ($000) $77,388 Shares 1,357,691 Est. Cost $76.48 Unrealized
A AGILENT TECHNOLOGIES INC 0.9%
Value ($000) $76,543 Shares 1,085,100 Est. Cost $36.59 Unrealized +71.4%
PRINCIPIA BIOPHARMA INC 0.9%
Value ($000) $76,139 Shares 2,605,713 Est. Cost $29.22 Unrealized
DECIPHERA PHARMACEUTICALS IN 0.9%
Value ($000) $75,640 Shares 1,953,500 Est. Cost $25.41 Unrealized
AERIE PHARMACEUTICALS INC 0.9%
Value ($000) $75,081 Shares 1,219,830 Est. Cost $44.54 Unrealized
RESTORBIO INC 0.9%
Value ($000) $73,132 Shares 4,830,387 Est. Cost $9.58 Unrealized
ARRAY BIOPHARMA INC 0.9%
Value ($000) $73,065 Shares 4,806,900 Est. Cost $5.98 Unrealized
MOH MOLINA HEALTHCARE INC 0.9%
Value ($000) $72,682 Shares 488,781 Est. Cost $127.64 Unrealized 0.0%
XRAY DENTSPLY SIRONA INC 0.9%
Value ($000) $71,298 Shares 1,889,200 Est. Cost $48.09 Unrealized -13.4%
MD MEDNAX INC 0.8%
Value ($000) $68,558 Shares 1,469,300 Est. Cost $48.83 Unrealized -6.0%
BLUEBIRD BIO INC 0.8%
Value ($000) $67,043 Shares 459,200 Est. Cost $127.27 Unrealized
CLOVIS ONCOLOGY INC 0.8%
Value ($000) $65,629 Shares 2,234,570 Est. Cost $86.21 Unrealized
IOVA IOVANCE BIOTHERAPEUTICS INC 0.8%
Value ($000) $62,419 Shares 5,548,326 Est. Cost $6.34 Unrealized +123.8%
PTCT PTC THERAPEUTICS INC 0.7%
Value ($000) $59,925 Shares 1,275,000 Est. Cost $41.38 Unrealized 0.0%
JNJ JOHNSON & JOHNSON 0.7%
Value ($000) $57,216 Shares 414,100 Est. Cost $90.07 Unrealized +20.0%
LOXO ONCOLOGY INC 0.7%
Value ($000) $56,374 Shares 330,000 Est. Cost $1.07 Unrealized
CRNX CRINETICS PHARMACEUTICALS IN 0.7%
Value ($000) $54,844 Shares 1,914,282 Est. Cost $29.69 Unrealized 0.0%
ARGX ARGENX SE 0.7%
Value ($000) $54,514 Shares 718,800 Est. Cost $38.81 Unrealized
IRWD IRONWOOD PHARMACEUTICALS INC 0.7%
Value ($000) $54,074 Shares 2,929,250 Est. Cost $10.99 Unrealized +43.8%
VRAYQ VIEWRAY INC 0.6%
Value ($000) $53,691 Shares 5,736,267 Est. Cost $4.68 Unrealized +110.1%
ISRG INTUITIVE SURGICAL INC 0.6%
Value ($000) $52,923 Shares 92,200 Est. Cost $104.83 Unrealized +69.4%
CRVS CORVUS PHARMACEUTICALS INC 0.6%
Value ($000) $51,202 Shares 5,967,584 Est. Cost $13.85 Unrealized -27.8%
EXEL EXELIXIS INC 0.6%
Value ($000) $49,650 Shares 2,801,900 Est. Cost $20.21 Unrealized -3.5%
UNH UNITEDHEALTH GROUP INC 0.6%
Value ($000) $49,616 Shares 186,500 Est. Cost $218.39 Unrealized +5.6%
BHC BAUSCH HEALTH COS INC 0.6%
Value ($000) $48,873 Shares 1,903,900 Est. Cost $22.90 Unrealized 0.0%
CNC CENTENE CORP DEL 0.6%
Value ($000) $48,849 Shares 337,400 Est. Cost $69.43 Unrealized 0.0%
ONC BEIGENE LTD 0.6%
Value ($000) $48,652 Shares 282,500 Est. Cost $46.26 Unrealized
HRTX HERON THERAPEUTICS INC 0.6%
Value ($000) $47,934 Shares 1,514,500 Est. Cost $21.87 Unrealized +70.3%
OBSEVA SA 0.6%
Value ($000) $46,978 Shares 2,605,531 Est. Cost $10.41 Unrealized
ASSEMBLY BIOSCIENCES INC 0.6%
Value ($000) $45,807 Shares 1,233,371 Est. Cost $30.27 Unrealized
EHTH EHEALTH INC 0.5%
Value ($000) $45,533 Shares 1,611,200 Est. Cost $11.97 Unrealized +121.7%
ARVN ARVINAS INC 0.5%
Value ($000) $44,636 Shares 2,645,865 Est. Cost $16.46 Unrealized 0.0%
GLPG GALAPAGOS NV 0.5%
Value ($000) $44,031 Shares 391,631 Est. Cost $76.76 Unrealized
TFX TELEFLEX INC 0.5%
Value ($000) $41,856 Shares 157,300 Est. Cost $253.19 Unrealized -1.8%
PRQR PROQR THRAPEUTICS N V 0.5%
Value ($000) $39,433 Shares 2,037,875 Est. Cost $13.23 Unrealized -19.6%
SPECTRUM PHARMACEUTICALS INC 0.5%
Value ($000) $38,060 Shares 2,265,500 Est. Cost $16.80 Unrealized
INSM INSMED INC 0.4%
Value ($000) $36,988 Shares 1,829,300 Est. Cost $22.80 Unrealized -0.8%
XTNT XTANT MED HLDGS INC 0.4%
Value ($000) $35,447 Shares 9,207,012 Est. Cost $6.59 Unrealized -19.8%
ZLAB ZAI LAB LTD 0.4%
Value ($000) $34,159 Shares 1,753,538 Est. Cost $24.35 Unrealized
KALA PHARMACEUTICALS INC 0.4%
Value ($000) $34,030 Shares 3,447,840 Est. Cost $20.66 Unrealized
AMGN AMGEN INC 0.4%
Value ($000) $31,425 Shares 151,600 Est. Cost $99.69 Unrealized +57.9%
TNDM TANDEM DIABETES CARE INC 0.4%
Value ($000) $30,609 Shares 714,500 Est. Cost $12.30 Unrealized +184.0%
INSYS THERAPEUTICS INC NEW 0.4%
Value ($000) $30,526 Shares 3,028,354 Est. Cost $27.55 Unrealized
RYTM RHYTHM PHARMACEUTICALS INC 0.4%
Value ($000) $30,376 Shares 1,041,353 Est. Cost $26.40 Unrealized +19.7%
FOAMIX PHARMACEUTICALS LTD 0.4%
Value ($000) $29,769 Shares 5,195,330 Est. Cost $5.20 Unrealized
PFE PFIZER INC 0.4%
Value ($000) $29,470 Shares 668,700 Est. Cost $18.91 Unrealized +46.2%
ABT ABBOTT LABS 0.3%
Value ($000) $28,911 Shares 394,100 Est. Cost $52.58 Unrealized +10.0%
SYNLOGIC INC 0.3%
Value ($000) $28,846 Shares 2,029,996 Est. Cost $15.62 Unrealized
CHRS COHERUS BIOSCIENCES INC 0.3%
Value ($000) $28,420 Shares 1,722,400 Est. Cost $21.85 Unrealized -18.9%
GILD GILEAD SCIENCES INC 0.3%
Value ($000) $28,151 Shares 364,600 Est. Cost $50.75 Unrealized +12.0%
SELECTA BIOSCIENCES INC 0.3%
Value ($000) $26,323 Shares 1,692,797 Est. Cost $13.99 Unrealized
VERRICA PHARMACEUTICALS INC 0.3%
Value ($000) $24,046 Shares 1,479,733 Est. Cost $19.73 Unrealized
SYK STRYKER CORP 0.3%
Value ($000) $23,134 Shares 130,200 Est. Cost $93.40 Unrealized +68.7%
INSMED INC 0.3%
Value ($000) $22,611 Shares 26,500,000 Est. Cost $0.89 Unrealized
CRSP CRISPR THERAPEUTICS AG 0.3%
Value ($000) $22,006 Shares 496,200 Est. Cost $53.67 Unrealized -2.4%
SVA SINOVAC BIOTECH LTD 0.3%
Value ($000) $21,637 Shares 2,839,500 Est. Cost $4.60 Unrealized +56.9%
INVITAE CORP 0.3%
Value ($000) $21,323 Shares 1,274,549 Est. Cost $11.59 Unrealized
FOLD AMICUS THERAPEUTICS INC 0.3%
Value ($000) $21,318 Shares 1,763,277 Est. Cost $14.05 Unrealized -0.5%
NTLA INTELLIA THERAPEUTICS INC 0.3%
Value ($000) $21,310 Shares 744,600 Est. Cost $26.61 Unrealized +9.4%
ALPINE IMMUNE SCIENCES INC 0.3%
Value ($000) $20,880 Shares 3,298,516 Est. Cost $11.60 Unrealized
AEGLEA BIOTHERAPEUTICS INC 0.2%
Value ($000) $20,724 Shares 2,165,524 Est. Cost $6.69 Unrealized
SCPHARMACEUTICALS INC 0.2%
Value ($000) $20,016 Shares 3,409,865 Est. Cost $12.09 Unrealized
AETNA INC NEW 0.2%
Value ($000) $19,920 Shares 98,200 Est. Cost $202.85 Unrealized
VRTX VERTEX PHARMACEUTICALS INC 0.2%
Value ($000) $19,274 Shares 100,000 Est. Cost $99.02 Unrealized +79.8%
RCKT ROCKET PHARMACEUTICALS INC 0.2%
Value ($000) $19,081 Shares 775,000 Est. Cost $16.31 Unrealized +33.0%
SEM SELECT MED HLDGS CORP 0.2%
Value ($000) $19,039 Shares 1,034,711 Est. Cost $7.32 Unrealized +30.2%
NBIX NEUROCRINE BIOSCIENCES INC 0.2%
Value ($000) $16,943 Shares 137,800 Est. Cost $86.76 Unrealized +30.8%
NTRA NATERA INC 0.2%
Value ($000) $16,377 Shares 684,086 Est. Cost $15.79 Unrealized +53.0%
AERPIO PHARMACEUTICALS INC 0.2%
Value ($000) $16,049 Shares 5,193,946 Est. Cost $4.15 Unrealized
VERONA PHARMA PLC 0.2%
Value ($000) $15,642 Shares 1,250,396 Est. Cost $11.76 Unrealized
NVO NOVO-NORDISK A S 0.2%
Value ($000) $15,556 Shares 330,000 Est. Cost $48.15 Unrealized
DBV TECHNOLOGIES S A 0.2%
Value ($000) $14,940 Shares 665,200 Est. Cost $30.00 Unrealized
IMMUNOGEN INC 0.2%
Value ($000) $13,913 Shares 1,469,189 Est. Cost $10.29 Unrealized
PIERIS PHARMACEUTICALS INC 0.2%
Value ($000) $13,753 Shares 2,455,900 Est. Cost $2.75 Unrealized
RADIUS HEALTH INC 0.2%
Value ($000) $13,580 Shares 762,900 Est. Cost $37.37 Unrealized
AVROBIO INC 0.2%
Value ($000) $12,968 Shares 250,000 Est. Cost $28.56 Unrealized
NABRIVA THERAPEUTICS PLC 0.2%
Value ($000) $12,540 Shares 4,644,600 Est. Cost $9.27 Unrealized
WRIGHT MED GROUP N V 0.1%
Value ($000) $12,245 Shares 8,746,583 Est. Cost $1.52 Unrealized
NOVUS THERAPEUTICS INC 0.1%
Value ($000) $11,848 Shares 2,537,110 Est. Cost $5.85 Unrealized
GLOBAL BLOOD THERAPEUTICS IN 0.1%
Value ($000) $11,761 Shares 309,500 Est. Cost $32.00 Unrealized
ACIU AC IMMUNE SA 0.1%
Value ($000) $11,520 Shares 1,440,000 Est. Cost $10.05 Unrealized 0.0%
DERMIRA INC 0.1%
Value ($000) $11,244 Shares 1,031,596 Est. Cost $9.20 Unrealized
CTI BIOPHARMA CORP 0.1%
Value ($000) $10,800 Shares 5,000,000 Est. Cost $3.31 Unrealized
HCA HCA HEALTHCARE INC 0.1%
Value ($000) $10,559 Shares 75,900 Est. Cost $90.31 Unrealized +29.1%
MCK MCKESSON CORP 0.1%
Value ($000) $9,829 Shares 74,100 Est. Cost $123.13 Unrealized 0.0%
ADAPY ADAPTIMMUNE THERAPEUTICS PLC 0.1%
Value ($000) $9,039 Shares 666,593 Est. Cost $7.98 Unrealized
ALLAKOS INC 0.1%
Value ($000) $8,998 Shares 200,000 Est. Cost $44.99 Unrealized
FLUIDIGM CORP DEL 0.1%
Value ($000) $8,625 Shares 10,000,000 Est. Cost $1.10 Unrealized
XENE XENON PHARMACEUTICALS INC 0.1%
Value ($000) $8,380 Shares 634,812 Est. Cost $7.72 Unrealized +50.0%
LAB FLUIDIGM CORP DEL 0.1%
Value ($000) $8,073 Shares 1,077,801 Est. Cost $23.26 Unrealized -69.4%
INOTEK PHARMACEUTICALS CORP 0.1%
Value ($000) $7,788 Shares 7,000,000 Est. Cost $1.36 Unrealized
NUVECTRA CORP 0.1%
Value ($000) $7,693 Shares 350,000 Est. Cost $21.98 Unrealized
BMRN BIOMARIN PHARMACEUTICAL INC 0.1%
Value ($000) $7,418 Shares 76,500 Est. Cost $86.40 Unrealized +15.5%
111 INC 0.1%
Value ($000) $6,760 Shares 500,000 Est. Cost $13.52 Unrealized
ATHENEX INC 0.1%
Value ($000) $6,682 Shares 430,000 Est. Cost $17.01 Unrealized
MCK MCKESSON CORP 0.1%
Value ($000) $6,633 Shares 50,000 Est. Cost $123.13 Unrealized 0.0%
ALKS ALKERMES PLC 0.1%
Value ($000) $6,154 Shares 145,000 Est. Cost $56.71 Unrealized -23.5%
MARINUS PHARMACEUTICALS INC 0.1%
Value ($000) $5,676 Shares 567,600 Est. Cost $7.64 Unrealized
CONSTELLATION PHARMCETICLS I 0.1%
Value ($000) $5,625 Shares 835,842 Est. Cost $6.73 Unrealized
ELECTROCORE INC 0.1%
Value ($000) $5,570 Shares 397,826 Est. Cost $16.51 Unrealized
RA MED SYS INC 0.1%
Value ($000) $5,460 Shares 300,000 Est. Cost $18.20 Unrealized
STIM NEURONETICS INC 0.1%
Value ($000) $4,809 Shares 150,000 Est. Cost $27.20 Unrealized +11.8%
MENLO THERAPEUTICS INC 0.1%
Value ($000) $4,656 Shares 472,729 Est. Cost $9.85 Unrealized
CPRX CATALYST PHARMACEUTICALS INC 0.1%
Value ($000) $4,166 Shares 1,102,000 Est. Cost $3.13 Unrealized 0.0%
GW PHARMACEUTICALS PLC 0.0%
Value ($000) $3,628 Shares 21,000 Est. Cost $112.66 Unrealized
SNDX SYNDAX PHARMACEUTICALS INC 0.0%
Value ($000) $3,531 Shares 437,000 Est. Cost $12.54 Unrealized -43.2%
MGTX MEIRAGTX HOLDINGS PLC 0.0%
Value ($000) $3,443 Shares 253,183 Est. Cost $10.80 Unrealized 0.0%
REALM THERAPEUTICS PLC 0.0%
Value ($000) $3,051 Shares 1,021,484 Est. Cost $2.99 Unrealized
ARSANIS INC 0.0%
Value ($000) $3,028 Shares 1,868,966 Est. Cost $12.76 Unrealized
IRWD IRONWOOD PHARMACEUTICALS INC 0.0%
Value ($000) $2,769 Shares 150,000 Est. Cost $10.99 Unrealized +43.8%
TESARO INC 0.0%
Value ($000) $2,625 Shares 67,281 Est. Cost $82.88 Unrealized
REDHILL BIOPHARMA LTD 0.0%
Value ($000) $2,516 Shares 284,900 Est. Cost $14.14 Unrealized
ADAMAS PHARMACEUTICALS INC 0.0%
Value ($000) $2,002 Shares 100,000 Est. Cost $20.02 Unrealized
ANAB ANAPTYSBIO INC 0.0%
Value ($000) $1,995 Shares 20,000 Est. Cost Unrealized
AEGERION PHARMACEUTICALS INC 0.0%
Value ($000) $1,551 Shares 2,000,000 Est. Cost $0.78 Unrealized
AFFIMED N V 0.0%
Value ($000) $1,421 Shares 326,650 Est. Cost $6.30 Unrealized
SIERRA ONCOLOGY INC 0.0%
Value ($000) $1,304 Shares 767,104 Est. Cost $1.53 Unrealized
BIOLINERX LTD 0.0%
Value ($000) $1,111 Shares 1,038,600 Est. Cost $1.62 Unrealized
RECRO PHARMA INC 0.0%
Value ($000) $763 Shares 107,357 Est. Cost $5.02 Unrealized
BIOMARIN PHARMACEUTICAL INC 0.0%
Value ($000) $602 Shares 500,000 Est. Cost $1.08 Unrealized
BIOMARIN PHARMACEUTICAL INC 0.0%
Value ($000) $517 Shares 500,000 Est. Cost $1.07 Unrealized
ALIMERA SCIENCES INC 0.0%
Value ($000) $245 Shares 250,000 Est. Cost $7.89 Unrealized
MEDIGUS LTD 0.0%
Value ($000) $51 Shares 15,000 Est. Cost $3.40 Unrealized