SPHERA FUNDS MANAGEMENT LTD. Quant / Systematic

Location: Tel Aviv, Israel

CIK: 0001496201 · Show all filings

Period: Q4 2014 (← Previous) (Next →)

Filing Date: Feb 12, 2015

Total Value: $587M (100.0% shares, 0.0% debt)

Holdings (125)

NVS Novartis AG 7.0%
Value $40.85M Shares 439,621 Est. Cost $84.65 Unrealized
Actavis plc 4.7%
Value $27.57M Shares 107,100 Est. Cost $241.28 Unrealized
PFE Pfizer Inc 4.6%
Value $27.23M Shares 874,013 Est. Cost $17.59 Unrealized +2.2%
TEVA Teva Pharmaceutical Industries 3.9%
Value $22.79M Shares 396,269 Est. Cost $51.69 Unrealized
SALIX PHARMACEUTICALS LT 3.1%
Value $18.22M Shares 158,500 Est. Cost $120.15 Unrealized
GILD Gilead Sciences Inc 3.1%
Value $17.91M Shares 190,000 Est. Cost $71.85 Unrealized 0.0%
Shire PLC 2.7%
Value $15.89M Shares 224,751 Est. Cost $80.71 Unrealized
Valeant Pharmaceuticals Intern 2.4%
Value $14.1M Shares 98,550 Est. Cost $131.20 Unrealized
BIIB Biogen Idec Inc 2.3%
Value $13.58M Shares 40,000 Est. Cost $323.51 Unrealized 0.0%
Isramco Negev 2 LP 1.9%
Value $11.13M Shares 64,958,387 Est. Cost $0.21 Unrealized
UTHR United Therapeutics Corp 1.6%
Value $9.562M Shares 73,840 Est. Cost $103.09 Unrealized +25.0%
Merck & Co Inc 1.6%
Value $9.514M Shares 167,530 Est. Cost $56.79 Unrealized
Mallinckrodt PLC 1.5%
Value $9.006M Shares 90,940 Est. Cost $90.15 Unrealized
BMY Bristol-Myers Squibb Co 1.5%
Value $8.855M Shares 150,000 Est. Cost $38.91 Unrealized 0.0%
ESLT Elbit Systems Ltd 1.5%
Value $8.853M Shares 144,759 Est. Cost $53.01 Unrealized -2.0%
Verint Systems Inc 1.5%
Value $8.515M Shares 146,108 Est. Cost $49.78 Unrealized
Allergan Inc/United States 1.4%
Value $8.238M Shares 250,000 Est. Cost Unrealized
BMRN BioMarin Pharmaceutical Inc 1.2%
Value $7.232M Shares 80,000 Est. Cost $60.50 Unrealized +37.5%
Bellicum Pharmaceuticals 1.2%
Value $6.956M Shares 331,514 Est. Cost $20.98 Unrealized
IWM iShares Russell 2000 Index Fun 1.1%
Value $6.495M Shares 54,300 Est. Cost $119.61 Unrealized
Kite Pharma Inc 1.1%
Value $6.4M Shares 110,970 Est. Cost $39.80 Unrealized
Sanofi 1.1%
Value $6.222M Shares 67,960 Est. Cost $113.14 Unrealized
AstraZeneca PLC 1.0%
Value $6.098M Shares 86,637 Est. Cost $71.44 Unrealized
LLY Eli Lilly & Co 1.0%
Value $6.009M Shares 87,100 Est. Cost $44.54 Unrealized +23.9%
Pharmacyclics Inc 1.0%
Value $5.971M Shares 48,840 Est. Cost $96.38 Unrealized
Apple Inc 1.0%
Value $5.828M Shares 52,803 Est. Cost $101.25 Unrealized
Auspex Pharmaceuticals Inc 1.0%
Value $5.777M Shares 110,074 Est. Cost $25.67 Unrealized
PTCT PTC Therapeutics Inc 1.0%
Value $5.695M Shares 110,000 Est. Cost $30.94 Unrealized +42.3%
Mylan Inc/PA 0.9%
Value $5.474M Shares 97,100 Est. Cost $45.49 Unrealized
Amgen Inc 0.9%
Value $5.457M Shares 120,200 Est. Cost Unrealized
AMAG Pharmaceuticals Inc 0.9%
Value $5.337M Shares 125,230 Est. Cost $31.91 Unrealized
Medivation Inc 0.9%
Value $5.291M Shares 53,115 Est. Cost $77.09 Unrealized
VNDA Vanda Pharmaceuticals Inc 0.9%
Value $5.275M Shares 368,390 Est. Cost $12.10 Unrealized -2.2%
XLF Financial Select Sector SPDR F 0.9%
Value $5.193M Shares 210,000 Est. Cost $24.73 Unrealized
Towers Watson & Co 0.8%
Value $4.793M Shares 42,350 Est. Cost $107.27 Unrealized
TJX TJX Cos Inc 0.8%
Value $4.638M Shares 67,630 Est. Cost $26.63 Unrealized +2.6%
Array BioPharma Inc 0.8%
Value $4.607M Shares 973,922 Est. Cost $3.98 Unrealized
Clovis Oncology Inc 0.8%
Value $4.589M Shares 81,955 Est. Cost $48.59 Unrealized
FOLD Amicus Therapeutics Inc 0.8%
Value $4.576M Shares 550,000 Est. Cost $6.86 Unrealized 0.0%
Dyax Corp 0.8%
Value $4.465M Shares 317,556 Est. Cost $9.60 Unrealized
GlaxoSmithKline PLC 0.7%
Value $4.197M Shares 98,200 Est. Cost $53.28 Unrealized
Forward Pharma A/S 0.7%
Value $4.166M Shares 200,000 Est. Cost $20.83 Unrealized
Orbotech Ltd 0.7%
Value $4.157M Shares 280,872 Est. Cost $14.74 Unrealized
Gilead Sciences Inc 0.7%
Value $3.954M Shares 394,200 Est. Cost Unrealized
CYTK Cytokinetics Inc 0.7%
Value $3.951M Shares 493,212 Est. Cost $4.54 Unrealized -5.4%
Relypsa Inc 0.7%
Value $3.915M Shares 127,100 Est. Cost $23.38 Unrealized
Broadcom Corp 0.7%
Value $3.848M Shares 88,800 Est. Cost $32.06 Unrealized
PBYI Puma Biotechnology Inc 0.7%
Value $3.841M Shares 20,296 Est. Cost $94.57 Unrealized +134.6%
Cymabay Therapeutics Inc 0.7%
Value $3.837M Shares 390,355 Est. Cost $6.84 Unrealized
ITRN Ituran Location and Control Lt 0.6%
Value $3.714M Shares 168,203 Est. Cost $22.40 Unrealized -5.3%
Receptos Inc 0.6%
Value $3.675M Shares 30,000 Est. Cost $55.92 Unrealized
VRTX Vertex Pharmaceuticals Inc 0.6%
Value $3.564M Shares 30,000 Est. Cost $95.21 Unrealized +18.3%
CVS CVS Caremark Corp 0.6%
Value $3.526M Shares 36,610 Est. Cost $54.39 Unrealized +18.5%
Applied Genetic Technologies C 0.6%
Value $3.471M Shares 165,124 Est. Cost $18.61 Unrealized
Aegerion Pharmaceuticals Inc 0.6%
Value $3.35M Shares 160,000 Est. Cost $20.94 Unrealized
XLV Health Care Select Sector SPDR 0.6%
Value $3.341M Shares 48,853 Est. Cost $59.09 Unrealized
Trevena Inc 0.6%
Value $3.288M Shares 549,811 Est. Cost $6.76 Unrealized
Acorda Therapeutics Inc 0.6%
Value $3.233M Shares 79,105 Est. Cost $33.75 Unrealized
CPRX Catalyst Pharmaceutical Partne 0.5%
Value $3.148M Shares 1,060,000 Est. Cost $2.66 Unrealized +3.2%
Marinus Pharmaceuticals Inc 0.5%
Value $3.094M Shares 293,533 Est. Cost $6.47 Unrealized
UNP Union Pacific Corp 0.5%
Value $3.06M Shares 25,689 Est. Cost $80.32 Unrealized +11.4%
SGMO Sangamo Biosciences Inc 0.5%
Value $3.042M Shares 200,000 Est. Cost $12.14 Unrealized 0.0%
MGNX MacroGenics Inc 0.5%
Value $2.953M Shares 84,198 Est. Cost $26.30 Unrealized -5.2%
Arrowhead Research Corp 0.5%
Value $2.952M Shares 400,000 Est. Cost $7.38 Unrealized
Celladon Corp 0.5%
Value $2.942M Shares 150,656 Est. Cost $14.95 Unrealized
SAGE Therapeutics Inc 0.5%
Value $2.918M Shares 79,724 Est. Cost $31.50 Unrealized
Dicerna Pharmaceuticals Inc 0.5%
Value $2.912M Shares 176,802 Est. Cost $16.47 Unrealized
Alder Biopharmaceuticals Inc 0.5%
Value $2.909M Shares 100,000 Est. Cost $12.68 Unrealized
SNA Snap-on Inc 0.5%
Value $2.891M Shares 21,140 Est. Cost $96.54 Unrealized +5.3%
Express Scripts Holding Co 0.5%
Value $2.876M Shares 33,966 Est. Cost $84.67 Unrealized
NPS Pharmaceuticals Inc 0.5%
Value $2.862M Shares 80,000 Est. Cost $27.53 Unrealized
Keryx Biopharmaceuticals Inc 0.5%
Value $2.83M Shares 200,000 Est. Cost $14.15 Unrealized
PRQR ProQR Therapeutics BV 0.5%
Value $2.817M Shares 130,000 Est. Cost $16.02 Unrealized -5.3%
Medicines Co/The 0.5%
Value $2.767M Shares 100,000 Est. Cost $27.67 Unrealized
Ocera Therapeutics Inc 0.5%
Value $2.683M Shares 421,254 Est. Cost $7.00 Unrealized
Tekmira Pharmaceuticals Corp 0.5%
Value $2.651M Shares 175,000 Est. Cost $15.15 Unrealized
Aerie Pharmaceuticals Inc 0.4%
Value $2.584M Shares 88,516 Est. Cost $18.90 Unrealized
SRPT Sarepta Therapeutics Inc 0.4%
Value $2.532M Shares 175,000 Est. Cost $16.93 Unrealized 0.0%
QURE uniQure B.V. 0.4%
Value $2.494M Shares 168,415 Est. Cost $12.24 Unrealized 0.0%
BCOMF B Communications Ltd 0.4%
Value $2.418M Shares 134,174 Est. Cost $15.32 Unrealized +6.2%
Cempra Inc 0.4%
Value $2.351M Shares 100,000 Est. Cost $23.51 Unrealized
Tokai Pharmaceuticals Inc 0.4%
Value $2.268M Shares 153,841 Est. Cost $15.14 Unrealized
Zafgen Inc 0.4%
Value $2.224M Shares 72,100 Est. Cost $19.65 Unrealized
CSX CSX Corp 0.4%
Value $2.161M Shares 59,648 Est. Cost $7.61 Unrealized +29.2%
ORA Ormat Industries 0.4%
Value $2.132M Shares 309,000 Est. Cost $25.22 Unrealized +0.2%
Vital Therapies Inc 0.3%
Value $2.042M Shares 81,900 Est. Cost $24.93 Unrealized
ENTA Enanta Pharmaceuticals Inc 0.3%
Value $2.034M Shares 40,000 Est. Cost $44.77 Unrealized 0.0%
NICE NICE Systems Ltd 0.3%
Value $2.008M Shares 39,652 Est. Cost $40.62 Unrealized
Concert Pharmaceuticals Inc 0.3%
Value $1.998M Shares 150,000 Est. Cost $13.21 Unrealized
Portola Pharmaceuticals Inc 0.3%
Value $1.982M Shares 70,000 Est. Cost $28.31 Unrealized
ELLO Ellomay Capital Ltd 0.3%
Value $1.977M Shares 203,778 Est. Cost $9.50 Unrealized -0.4%
SBUX Starbucks Corp 0.3%
Value $1.969M Shares 24,000 Est. Cost $31.27 Unrealized 0.0%
La Jolla Pharmaceutical Co 0.3%
Value $1.849M Shares 100,230 Est. Cost $9.61 Unrealized
Teva Pharmaceutical Industries 0.3%
Value $1.801M Shares 464,200 Est. Cost Unrealized
Cell Therapeutics Inc 0.3%
Value $1.77M Shares 750,000 Est. Cost $2.36 Unrealized
Intercept Pharmaceuticals Inc 0.3%
Value $1.56M Shares 10,000 Est. Cost $236.66 Unrealized
Check Point Software Technolog 0.3%
Value $1.547M Shares 19,688 Est. Cost $78.58 Unrealized
Achillion Pharmaceuticals Inc 0.3%
Value $1.538M Shares 125,538 Est. Cost $12.25 Unrealized
Valeant Pharmaceuticals Intern 0.2%
Value $1.395M Shares 97,200 Est. Cost Unrealized
Amgen Inc 0.2%
Value $1.362M Shares 8,550 Est. Cost $118.79 Unrealized
PRTA Prothena Corp PLC 0.2%
Value $1.3M Shares 62,632 Est. Cost $21.03 Unrealized -0.8%
WIX Wix.com Ltd 0.2%
Value $1.241M Shares 59,108 Est. Cost $19.07 Unrealized 0.0%
Ignyta Inc 0.2%
Value $1.227M Shares 179,055 Est. Cost $8.30 Unrealized
GenVec Inc 0.2%
Value $1.195M Shares 558,325 Est. Cost $2.65 Unrealized
MannKind Corp 0.2%
Value $1.155M Shares 300,000 Est. Cost Unrealized
Medgenics Inc 0.2%
Value $1.139M Shares 225,000 Est. Cost $5.06 Unrealized
NBIX Neurocrine Biosciences Inc 0.2%
Value $1.117M Shares 50,000 Est. Cost $18.95 Unrealized 0.0%
KMDA Kamada Ltd 0.2%
Value $1.089M Shares 293,727 Est. Cost $3.69 Unrealized 0.0%
Eleven Biotherapeutics Inc 0.2%
Value $1.035M Shares 87,110 Est. Cost $11.88 Unrealized
Repros Therapeutics Inc 0.2%
Value $997K Shares 100,000 Est. Cost $9.97 Unrealized
NewLink Genetics Corp 0.2%
Value $994K Shares 25,000 Est. Cost $39.76 Unrealized
ZS Pharma Inc 0.1%
Value $860K Shares 20,682 Est. Cost $39.21 Unrealized
Oncothyreon Inc 0.1%
Value $813K Shares 428,000 Est. Cost $1.76 Unrealized
Juno Therapeutics Inc 0.1%
Value $783K Shares 15,000 Est. Cost $52.20 Unrealized
Mast Therapeutics Inc 0.1%
Value $770K Shares 1,374,900 Est. Cost $0.56 Unrealized
Palatin Technologies Inc 0.1%
Value $759K Shares 1,040,266 Est. Cost $0.93 Unrealized
AcelRx Pharmaceuticals Inc 0.1%
Value $673K Shares 100,000 Est. Cost $5.49 Unrealized
Ardelyx Inc 0.1%
Value $618K Shares 32,700 Est. Cost $18.90 Unrealized
KaloBios Pharmaceuticals Inc 0.1%
Value $605K Shares 349,560 Est. Cost $4.42 Unrealized
Mellanox Technologies Ltd 0.1%
Value $535K Shares 12,517 Est. Cost $42.74 Unrealized
Israel Chemicals Ltd 0.0%
Value $291K Shares 40,116 Est. Cost $7.23 Unrealized
Alcobra Ltd 0.0%
Value $144K Shares 38,500 Est. Cost $3.74 Unrealized
Energy Select Sector SPDR Fund 0.0%
Value $116K Shares 50,000 Est. Cost Unrealized
Novavax Inc 0.0%
Value $9,000 Shares 1,543 Est. Cost $5.83 Unrealized
GlaxoSmithKline PLC 0.0%
Value $7,000 Shares 291,300 Est. Cost Unrealized