| FMR LLC | 22,382,002 | $78,113 |
| ARK Investment Management LLC | 12,550,799 | $43,802 |
| BlackRock, Inc. | 11,333,432 | $39,554 |
| Redmile Group, LLC | 8,253,316 | $28,804 |
| VANGUARD GROUP INC | 7,910,205 | $27,607 |
| STATE STREET CORP | 5,990,877 | $20,908 |
| ADVANCED MICRO DEVICES INC | 5,714,285 | $19,943 |
| GEODE CAPITAL MANAGEMENT, LLC | 3,239,623 | $11,309 |
| AMERIPRISE FINANCIAL INC | 3,196,577 | $11,156 |
| UBS Group AG | 2,699,505 | $9,421 |
| Schonfeld Strategic Advisors LLC | 2,349,725 | $8,201 |
| Woodline Partners LP | 2,280,783 | $7,960 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,156,067 | $8 |
| BAKER BROS. ADVISORS LP | 2,134,803 | $7,450 |
| CITADEL ADVISORS LLC | 1,943,636 | $6,783 |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 1,719,849 | $6,002 |
| MORGAN STANLEY | 1,478,838 | $5,161 |
| Parkman Healthcare Partners LLC | 1,458,652 | $5,091 |
| Sumitomo Mitsui Trust Holdings, Inc. | 1,424,778 | $4,972 |
| Nikko Asset Management Americas, Inc. | 1,424,778 | $4,958 |
| TWO SIGMA INVESTMENTS, LP | 1,418,416 | $4,950 |
| FRED ALGER MANAGEMENT, LLC | 1,206,800 | $4,212 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,115,373 | $3,893 |
| HEIGHTS CAPITAL MANAGEMENT, INC | 1,065,640 | $3,719 |
| GOLDMAN SACHS GROUP INC | 1,023,775 | $3,573 |
| NORTHERN TRUST CORP | 988,803 | $3,451 |
| Casdin Capital, LLC | 973,260 | $3,397 |
| BNP PARIBAS ARBITRAGE, SA | 795,034 | $2,775 |
| ROYCE & ASSOCIATES LP | 735,353 | $2,566 |
| DIMENSIONAL FUND ADVISORS LP | 655,866 | $2,289 |
| LAZARD ASSET MANAGEMENT LLC | 555,359 | $1,938 |
| BARCLAYS PLC | 509,002 | $1,776 |
| IQ EQ FUND MANAGEMENT (IRELAND) Ltd | 470,386 | $1,642 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 423,911 | $1,479 |
| WELLINGTON MANAGEMENT GROUP LLP | 410,124 | $1,431 |
| Bank of New York Mellon Corp | 340,614 | $1,189 |
| Nuveen, LLC | 339,769 | $1,186 |
| TWO SIGMA ADVISERS, LP | 314,300 | $1,097 |
| BANK OF AMERICA CORP /DE/ | 313,832 | $1,095 |
| PLATINUM INVESTMENT MANAGEMENT LTD | 237,764 | $830 |
| MILLENNIUM MANAGEMENT LLC | 219,348 | $766 |
| PIER 88 INVESTMENT PARTNERS LLC | 205,800 | $718 |
| Rafferty Asset Management, LLC | 204,822 | $715 |
| BRYN MAWR TRUST Co | 189,522 | $661 |
| JPMORGAN CHASE & CO | 169,932 | $593 |
| RHUMBLINE ADVISERS | 160,709 | $561 |
| ALLIANCEBERNSTEIN L.P. | 157,990 | $551 |
| WELLS FARGO & COMPANY/MN | 155,640 | $543 |
| Independent Advisor Alliance | 153,856 | $537 |
| VICTORY CAPITAL MANAGEMENT INC | 152,286 | $531 |
| Institute for Wealth Management, LLC. | 145,792 | $509 |
| AMERICAN CENTURY COMPANIES INC | 143,581 | $501 |
| XTX Topco Ltd | 136,874 | $478 |
| RAYMOND JAMES FINANCIAL INC | 135,109 | $472 |
| ROYAL BANK OF CANADA | 134,974 | $470 |
| DEUTSCHE BANK AG\ | 92,148 | $322 |
| JANE STREET GROUP, LLC | 78,104 | $273 |
| KING LUTHER CAPITAL MANAGEMENT CORP | 77,520 | $271 |
| PROFUND ADVISORS LLC | 76,491 | $267 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 74,967 | $262 |
| HENGEHOLD CAPITAL MANAGEMENT LLC | 73,716 | $257 |
| Creative Planning | 73,561 | $257 |
| HSBC HOLDINGS PLC | 66,234 | $230 |
| SBI Securities Co., Ltd. | 63,127 | $220 |
| GRIFFIN ASSET MANAGEMENT, INC. | 56,760 | $198 |
| ENVESTNET ASSET MANAGEMENT INC | 56,165 | $196 |
| Invesco Ltd. | 54,550 | $190 |
| MetLife Investment Management, LLC | 52,330 | $183 |
| INTECH INVESTMENT MANAGEMENT LLC | 47,150 | $165 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 41,260 | $144 |
| SG Americas Securities, LLC | 40,928 | $0 |
| AXQ CAPITAL, LP | 40,108 | $140 |
| VISTA CAPITAL PARTNERS, INC. | 39,317 | $137 |
| MH & ASSOCIATES SECURITIES MANAGEMENT CORP /ADV | 37,651 | $131 |
| AQR CAPITAL MANAGEMENT LLC | 34,806 | $121 |
| China Universal Asset Management Co., Ltd. | 34,503 | $120 |
| Police & Firemen's Retirement System of New Jersey | 33,650 | $117 |
| CITIGROUP INC | 30,775 | $107 |
| Clarius Group, LLC | 30,000 | $105 |
| Alpha Cubed Investments, LLC | 26,230 | $92 |
| LPL Financial LLC | 25,093 | $88 |
| NEW YORK STATE COMMON RETIREMENT FUND | 24,700 | $86 |
| Voya Investment Management LLC | 23,309 | $81 |
| Scientech Research LLC | 21,561 | $75 |
| OSAIC HOLDINGS, INC. | 20,304 | $71 |
| KESTRA PRIVATE WEALTH SERVICES, LLC | 20,300 | $71 |
| DKM Wealth Management, Inc. | 20,000 | $70 |
| DELAP WEALTH ADVISORY, LLC | 19,470 | $68 |
| Brooklyn Investment Group | 18,878 | $65 |
| Cherry Creek Investment Advisors, Inc. | 18,625 | $65 |
| Abel Hall, LLC | 15,422 | $54 |
| JONES FINANCIAL COMPANIES LLLP | 14,956 | $52 |
| Cresset Asset Management, LLC | 14,500 | $51 |
| COMMONWEALTH EQUITY SERVICES, LLC | 14,279 | $50 |
| Legal & General Group Plc | 13,494 | $47 |
| Cambridge Investment Research Advisors, Inc. | 12,875 | $0 |
| AssuredPartners Investment Advisors, LLC | 12,237 | $43 |
| GSA CAPITAL PARTNERS LLP | 11,922 | $0 |
| Russell Investments Group, Ltd. | 11,478 | $40 |
| Ameritas Investment Partners, Inc. | 11,142 | $39 |
| 41 other institutions | 124,696 | $389 |