| FMR LLC | 24,688,109 | $105,171 |
| VR Adviser, LLC | 15,561,500 | $66,292 |
| PERCEPTIVE ADVISORS LLC | 9,680,185 | $41,238 |
| Kynam Capital Management, LP | 8,966,077 | $38,195 |
| VANGUARD GROUP INC | 8,475,584 | $36,106 |
| Commodore Capital LP | 7,692,300 | $32,769 |
| Point72 Asset Management, L.P. | 5,189,538 | $22,107 |
| STATE STREET CORP | 5,140,931 | $21,900 |
| BAKER BROS. ADVISORS LP | 4,250,826 | $18,109 |
| ADAR1 Capital Management, LLC | 4,182,769 | $17,819 |
| BALYASNY ASSET MANAGEMENT L.P. | 3,872,202 | $16,496 |
| Financial Engines Advisors L.L.C. | 3,828,717 | $16,310 |
| BlackRock, Inc. | 3,669,393 | $15,632 |
| ORBIMED ADVISORS LLC | 3,525,650 | $15,019 |
| Ikarian Capital, LLC | 3,172,616 | $13,515 |
| Vivo Capital, LLC | 2,884,615 | $12,288 |
| Eversept Partners, LP | 2,507,090 | $10,680 |
| GOLDMAN SACHS GROUP INC | 2,460,944 | $10,484 |
| Woodline Partners LP | 2,337,005 | $9,956 |
| TWO SIGMA INVESTMENTS, LP | 1,560,755 | $6,649 |
| GEODE CAPITAL MANAGEMENT, LLC | 1,525,666 | $6,503 |
| DIMENSIONAL FUND ADVISORS LP | 1,289,656 | $5,492 |
| MARSHALL WACE, LLP | 1,156,936 | $4,929 |
| Qube Research & Technologies Ltd | 1,061,128 | $4,520 |
| STEMPOINT CAPITAL LP | 1,036,311 | $4,415 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 981,598 | $4,182 |
| BOOTHBAY FUND MANAGEMENT, LLC | 894,663 | $3,811 |
| BANK OF AMERICA CORP /DE/ | 876,305 | $3,733 |
| ACADIAN ASSET MANAGEMENT LLC | 856,056 | $4 |
| Exome Asset Management LLC | 745,305 | $3,175 |
| Elmind Capital, LP | 700,000 | $2,982 |
| JANE STREET GROUP, LLC | 607,218 | $2,587 |
| Assenagon Asset Management S.A. | 592,696 | $2,525 |
| FIRST TRUST ADVISORS LP | 423,168 | $1,803 |
| NORTHERN TRUST CORP | 415,178 | $1,769 |
| MORGAN STANLEY | 401,191 | $1,709 |
| SILVERARC CAPITAL MANAGEMENT, LLC | 385,974 | $1,644 |
| SCHULHOFF & CO INC | 374,850 | $1,597 |
| UBS Group AG | 370,739 | $1,579 |
| CITADEL ADVISORS LLC | 342,304 | $1,458 |
| BARCLAYS PLC | 336,525 | $1,434 |
| TWO SIGMA ADVISERS, LP | 335,524 | $1,429 |
| Bank of New York Mellon Corp | 328,248 | $1,398 |
| RAYMOND JAMES FINANCIAL INC | 316,971 | $1,350 |
| MILLENNIUM MANAGEMENT LLC | 289,653 | $1,234 |
| Rafferty Asset Management, LLC | 273,584 | $1,165 |
| AMERIPRISE FINANCIAL INC | 229,599 | $989 |
| PRELUDE CAPITAL MANAGEMENT, LLC | 206,526 | $880 |
| EAM Investors, LLC | 203,823 | $868 |
| HighVista Strategies LLC | 193,941 | $826 |
| SEI INVESTMENTS CO | 124,124 | $529 |
| LPL Financial LLC | 113,440 | $483 |
| CANADA PENSION PLAN INVESTMENT BOARD | 104,200 | $444 |
| Aspire Growth Partners LLC | 102,254 | $436 |
| NLB Skladi, upravljanje premozenja, d.o.o. | 100,000 | $426 |
| PROFUND ADVISORS LLC | 98,633 | $420 |
| CITIGROUP INC | 96,326 | $410 |
| OMERS ADMINISTRATION Corp | 87,800 | $374 |
| GSA CAPITAL PARTNERS LLP | 81,886 | $0 |
| Velan Capital Investment Management LP | 80,000 | $341 |
| HRT FINANCIAL LP | 71,867 | $0 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 68,687 | $293 |
| Miller Financial Services LLC | 68,000 | $290 |
| Virtus Investment Advisers, LLC | 63,491 | $270 |
| Brooklyn Investment Group | 61,474 | $258 |
| Congress Park Capital LLC | 58,922 | $251 |
| Merit Financial Group, LLC | 53,243 | $227 |
| SG Americas Securities, LLC | 53,109 | $0 |
| Hudson Bay Capital Management LP | 50,990 | $217 |
| Squarepoint Ops LLC | 49,897 | $213 |
| Seven Fleet Capital Management LP | 48,898 | $208 |
| Susquehanna Portfolio Strategies, LLC | 48,012 | $205 |
| XTX Topco Ltd | 47,991 | $204 |
| Formidable Asset Management, LLC | 45,763 | $195 |
| Toroso Investments, LLC | 45,763 | $195 |
| Baader Bank Aktiengesellschaft | 45,000 | $192 |
| Private Advisor Group, LLC | 44,002 | $187 |
| Lighthouse Investment Partners, LLC | 32,040 | $136 |
| Cambria Investment Management, L.P. | 31,332 | $133 |
| Empowered Funds, LLC | 31,332 | $133 |
| China Universal Asset Management Co., Ltd. | 27,609 | $118 |
| Truvestments Capital LLC | 27,428 | $117 |
| Vanguard Personalized Indexing Management, LLC | 26,765 | $114 |
| Engineers Gate Manager LP | 26,539 | $113 |
| MANGROVE PARTNERS IM, LLC | 26,265 | $112 |
| HB Wealth Management, LLC | 25,000 | $107 |
| Tower Research Capital LLC (TRC) | 24,794 | $106 |
| JPMORGAN CHASE & CO | 24,363 | $104 |
| SIMPLEX TRADING, LLC | 24,051 | $102 |
| Jefferies Financial Group Inc. | 23,764 | $101 |
| Ethos Financial Group, LLC | 23,697 | $101 |
| Mariner, LLC | 22,180 | $94 |
| Invesco Ltd. | 21,976 | $94 |
| State of Wyoming | 21,511 | $92 |
| Jain Global LLC | 21,212 | $90 |
| OSAIC HOLDINGS, INC. | 19,410 | $83 |
| Sanctuary Advisors, LLC | 19,140 | $82 |
| Forefront Analytics, LLC | 18,699 | $80 |
| TWINBEECH CAPITAL LP | 17,600 | $75 |
| WestHill Financial Advisors, Inc. | 17,082 | $73 |
| 22 other institutions | 192,406 | $816 |