SPHERA FUNDS MANAGEMENT LTD. Quant / Systematic

CIK: 0001496201 · Show all filings

Period: Q2 2025 (← Previous) (Next →)

Filing Date: Aug 14, 2025

Total Value ($000): $426,140 (100.0% shares, 0.0% debt)

Holdings (110)

TEVA TEVA PHARMACEUTICAL INDS LTD 6.4%
Value ($000) $27,168 Shares 1,620,990 Est. Cost $15.12 Unrealized
NVMI NOVA LTD 4.9%
Value ($000) $20,870 Shares 75,836 Est. Cost $213.92 Unrealized -4.9%
XBI SPDR SERIES TRUST 3.9%
Value ($000) $16,586 Shares 200,000 Est. Cost Unrealized
SNDX SYNDAX PHARMACEUTICALS INC 3.5%
Value ($000) $14,718 Shares 1,571,564 Est. Cost $17.38 Unrealized -36.7%
TSEM TOWER SEMICONDUCTOR LTD 2.7%
Value ($000) $11,476 Shares 264,722 Est. Cost $37.89 Unrealized +1.3%
CYTK CYTOKINETICS INC 2.5%
Value ($000) $10,795 Shares 326,718 Est. Cost $40.28 Unrealized -13.7%
SNY SANOFI 2.5%
Value ($000) $10,605 Shares 219,515 Est. Cost $46.09 Unrealized
BIIB BIOGEN INC 2.4%
Value ($000) $10,391 Shares 82,738 Est. Cost $158.50 Unrealized -21.4%
AZN ASTRAZENECA PLC 2.2%
Value ($000) $9,438 Shares 135,060 Est. Cost $54.50 Unrealized
LLY ELI LILLY & CO 2.1%
Value ($000) $8,996 Shares 11,540 Est. Cost $258.77 Unrealized +198.9%
NVDA NVIDIA CORPORATION 2.0%
Value ($000) $8,613 Shares 54,515 Est. Cost $126.31 Unrealized -0.4%
CLDX CELLDEX THERAPEUTICS INC NEW 2.0%
Value ($000) $8,538 Shares 419,540 Est. Cost $32.36 Unrealized -39.9%
NVO NOVO-NORDISK A S 1.7%
Value ($000) $7,294 Shares 105,677 Est. Cost $94.01 Unrealized
AMZN AMAZON COM INC 1.7%
Value ($000) $7,117 Shares 32,441 Est. Cost $141.58 Unrealized +39.8%
CIDARA THERAPEUTICS INC 1.6%
Value ($000) $6,722 Shares 138,001 Est. Cost $45.34 Unrealized
RARE ULTRAGENYX PHARMACEUTICAL IN 1.5%
Value ($000) $6,567 Shares 180,600 Est. Cost $46.22 Unrealized -22.0%
ORA ORMAT TECHNOLOGIES INC 1.5%
Value ($000) $6,533 Shares 78,000 Est. Cost $76.19 Unrealized -2.2%
MLYS MINERALYS THERAPEUTICS INC 1.5%
Value ($000) $6,508 Shares 480,974 Est. Cost $12.16 Unrealized +19.1%
FBRX FORTE BIOSCIENCES INC 1.5%
Value ($000) $6,402 Shares 495,109 Est. Cost $8.61 Unrealized 0.0%
META META PLATFORMS INC 1.5%
Value ($000) $6,293 Shares 8,526 Est. Cost $353.49 Unrealized +74.4%
JNJ JOHNSON & JOHNSON 1.5%
Value ($000) $6,237 Shares 40,831 Est. Cost $136.97 Unrealized +10.1%
MLTX MOONLAKE IMMUNOTHERAPEUTICS 1.4%
Value ($000) $5,900 Shares 125,000 Est. Cost Unrealized
MSFT MICROSOFT CORP 1.4%
Value ($000) $5,865 Shares 11,792 Est. Cost $379.13 Unrealized +14.0%
FOLD AMICUS THERAPEUTICS INC 1.3%
Value ($000) $5,677 Shares 990,718 Est. Cost $6.45 Unrealized 0.0%
ORMAT TECHNOLOGIES INC 1.3%
Value ($000) $5,610 Shares 5,037,000 Est. Cost $1.04 Unrealized
PHVS PHARVARIS N V 1.3%
Value ($000) $5,455 Shares 309,931 Est. Cost $22.21 Unrealized -27.4%
ELDN ELEDON PHARMACEUTICALS INC 1.2%
Value ($000) $5,311 Shares 1,959,610 Est. Cost $3.15 Unrealized -4.8%
TVTX TRAVERE THERAPEUTICS INC 1.2%
Value ($000) $4,963 Shares 335,333 Est. Cost $17.24 Unrealized -3.8%
ABBV ABBVIE INC 1.1%
Value ($000) $4,688 Shares 25,256 Est. Cost $93.90 Unrealized +94.5%
GSK GSK PLC 1.1%
Value ($000) $4,685 Shares 122,000 Est. Cost $35.22 Unrealized
PRAX PRAXIS PRECISION MEDICINES I 1.1%
Value ($000) $4,615 Shares 109,757 Est. Cost $51.58 Unrealized -26.2%
NVS NOVARTIS AG 1.1%
Value ($000) $4,477 Shares 37,000 Est. Cost $92.00 Unrealized
TRVI TREVI THERAPEUTICS INC 1.0%
Value ($000) $4,376 Shares 799,957 Est. Cost $6.22 Unrealized 0.0%
MAZE MAZE THERAPEUTICS INC 1.0%
Value ($000) $4,374 Shares 356,453 Est. Cost $12.04 Unrealized -13.6%
ANNX ANNEXON INC 1.0%
Value ($000) $4,235 Shares 1,764,387 Est. Cost $5.32 Unrealized -62.3%
PRAX PRAXIS PRECISION MEDICINES I 1.0%
Value ($000) $4,205 Shares 100,000 Est. Cost $51.58 Unrealized -26.2%
TLT ISHARES TR 1.0%
Value ($000) $4,148 Shares 47,000 Est. Cost Unrealized
IMVT IMMUNOVANT INC 1.0%
Value ($000) $4,108 Shares 256,743 Est. Cost $19.52 Unrealized -22.5%
ORIC ORIC PHARMACEUTICALS INC 0.9%
Value ($000) $4,006 Shares 394,693 Est. Cost $8.38 Unrealized -19.9%
MRK MERCK & CO INC 0.9%
Value ($000) $3,847 Shares 48,600 Est. Cost $73.08 Unrealized +5.9%
ACAD ACADIA PHARMACEUTICALS INC 0.9%
Value ($000) $3,773 Shares 174,900 Est. Cost $18.59 Unrealized 0.0%
BBIO BRIDGEBIO PHARMA INC 0.9%
Value ($000) $3,761 Shares 87,108 Est. Cost $25.12 Unrealized +44.8%
RARE ULTRAGENYX PHARMACEUTICAL IN 0.9%
Value ($000) $3,639 Shares 100,085 Est. Cost $46.22 Unrealized -22.0%
RNAM AVIDITY BIOSCIENCES INC 0.8%
Value ($000) $3,578 Shares 126,000 Est. Cost $30.93 Unrealized -3.6%
ACOG ALPHA COGNITION INC 0.8%
Value ($000) $3,514 Shares 376,649 Est. Cost $5.61 Unrealized +30.7%
RZLT REZOLUTE INC 0.8%
Value ($000) $3,351 Shares 751,447 Est. Cost $3.37 Unrealized +10.1%
HELP CYBIN INC 0.8%
Value ($000) $3,342 Shares 398,309 Est. Cost $9.89 Unrealized -26.5%
AMAT APPLIED MATLS INC 0.8%
Value ($000) $3,295 Shares 18,000 Est. Cost $166.66 Unrealized -5.5%
ARWR ARROWHEAD PHARMACEUTICALS IN 0.8%
Value ($000) $3,207 Shares 202,996 Est. Cost $19.90 Unrealized -27.9%
IMTX IMMATICS N.V 0.7%
Value ($000) $3,137 Shares 583,105 Est. Cost $11.13 Unrealized -55.4%
SVRA SAVARA INC 0.7%
Value ($000) $2,987 Shares 1,310,233 Est. Cost $3.84 Unrealized -29.3%
UBER UBER TECHNOLOGIES INC 0.7%
Value ($000) $2,799 Shares 30,000 Est. Cost $71.41 Unrealized +15.3%
SRPT SAREPTA THERAPEUTICS INC 0.6%
Value ($000) $2,724 Shares 159,323 Est. Cost $120.64 Unrealized -64.6%
CAMT CAMTEK LTD 0.6%
Value ($000) $2,704 Shares 31,976 Est. Cost $88.36 Unrealized -23.7%
ESLT ELBIT SYS LTD 0.6%
Value ($000) $2,697 Shares 6,000 Est. Cost $403.82 Unrealized 0.0%
PANW PALO ALTO NETWORKS INC 0.6%
Value ($000) $2,684 Shares 13,114 Est. Cost $185.70 Unrealized 0.0%
WIX WIX COM LTD 0.6%
Value ($000) $2,683 Shares 16,931 Est. Cost $141.49 Unrealized +13.8%
AMGN AMGEN INC 0.6%
Value ($000) $2,652 Shares 9,500 Est. Cost $287.24 Unrealized -3.3%
SEDG SOLAREDGE TECHNOLOGIES INC 0.6%
Value ($000) $2,611 Shares 127,966 Est. Cost $15.39 Unrealized +7.5%
ELVN ENLIVEN THERAPEUTICS INC 0.6%
Value ($000) $2,578 Shares 128,515 Est. Cost $21.18 Unrealized -10.6%
SRPT SAREPTA THERAPEUTICS INC 0.6%
Value ($000) $2,565 Shares 150,000 Est. Cost $120.64 Unrealized -64.6%
SKYE SKYE BIOSCIENCE INC 0.5%
Value ($000) $2,251 Shares 538,434 Est. Cost $10.78 Unrealized -80.8%
BBIO BRIDGEBIO PHARMA INC 0.5%
Value ($000) $2,155 Shares 49,900 Est. Cost $25.12 Unrealized +44.8%
DYN DYNE THERAPEUTICS INC 0.5%
Value ($000) $2,108 Shares 221,416 Est. Cost $27.02 Unrealized -59.3%
PFE PFIZER INC 0.5%
Value ($000) $2,085 Shares 86,000 Est. Cost $36.55 Unrealized -38.9%
BHVN BIOHAVEN LTD 0.5%
Value ($000) $2,051 Shares 145,372 Est. Cost $33.08 Unrealized -46.1%
SRRK SCHOLAR ROCK HLDG CORP 0.5%
Value ($000) $2,037 Shares 57,497 Est. Cost $8.78 Unrealized +257.5%
89BIO INC 0.5%
Value ($000) $2,020 Shares 205,675 Est. Cost $13.61 Unrealized
GPCR STRUCTURE THERAPEUTICS INC 0.5%
Value ($000) $1,990 Shares 95,931 Est. Cost $17.74 Unrealized
JANX JANUX THERAPEUTICS INC 0.5%
Value ($000) $1,983 Shares 85,840 Est. Cost $45.95 Unrealized -42.7%
APLS APELLIS PHARMACEUTICALS INC 0.5%
Value ($000) $1,979 Shares 114,346 Est. Cost $37.03 Unrealized -50.0%
CRM SALESFORCE INC 0.4%
Value ($000) $1,854 Shares 6,800 Est. Cost $309.01 Unrealized -13.9%
ENGN ENGENE HOLDINGS INC 0.4%
Value ($000) $1,836 Shares 504,409 Est. Cost $7.77 Unrealized -51.7%
CYBERARK SOFTWARE LTD 0.4%
Value ($000) $1,628 Shares 4,000 Est. Cost $406.88 Unrealized
MRVL MARVELL TECHNOLOGY INC 0.3%
Value ($000) $1,450 Shares 18,730 Est. Cost $67.65 Unrealized -7.9%
COGT COGENT BIOSCIENCES INC 0.3%
Value ($000) $1,436 Shares 200,000 Est. Cost $7.84 Unrealized -29.3%
ASTRIA THERAPEUTICS INC 0.3%
Value ($000) $1,380 Shares 257,402 Est. Cost $7.84 Unrealized
KURA KURA ONCOLOGY INC 0.3%
Value ($000) $1,359 Shares 235,522 Est. Cost $18.44 Unrealized -66.8%
IBIT ISHARES BITCOIN TRUST ETF 0.3%
Value ($000) $1,313 Shares 21,455 Est. Cost $55.74 Unrealized
NTLA INTELLIA THERAPEUTICS INC 0.3%
Value ($000) $1,208 Shares 128,780 Est. Cost $20.48 Unrealized -59.9%
VTYX VENTYX BIOSCIENCES INC 0.3%
Value ($000) $1,189 Shares 555,814 Est. Cost $5.44 Unrealized -70.3%
AMD ADVANCED MICRO DEVICES INC 0.3%
Value ($000) $1,171 Shares 8,250 Est. Cost $108.87 Unrealized 0.0%
NNDM NANO DIMENSION LTD 0.3%
Value ($000) $1,162 Shares 717,518 Est. Cost $1.59 Unrealized
DAWN DAY ONE BIOPHARMACEUTICALS I 0.3%
Value ($000) $1,140 Shares 175,371 Est. Cost $13.06 Unrealized -47.3%
CEVA CEVA INC 0.3%
Value ($000) $1,075 Shares 48,920 Est. Cost $32.13 Unrealized -30.8%
CATX PERSPECTIVE THERAPEUTICS INC 0.3%
Value ($000) $1,068 Shares 310,343 Est. Cost $14.46 Unrealized -81.7%
COGT COGENT BIOSCIENCES INC 0.2%
Value ($000) $1,032 Shares 143,693 Est. Cost $7.84 Unrealized -29.3%
KRYS KRYSTAL BIOTECH INC 0.2%
Value ($000) $1,008 Shares 7,335 Est. Cost $146.88 Unrealized 0.0%
TSHA TAYSHA GENE THERAPIES INC 0.2%
Value ($000) $970 Shares 420,000 Est. Cost $2.17 Unrealized 0.0%
PROMIS NEUROSCIENCES INC 0.2%
Value ($000) $919 Shares 1,899,297 Est. Cost $1.96 Unrealized
VTGN VISTAGEN THERAPEUTICS INC 0.2%
Value ($000) $896 Shares 447,939 Est. Cost $3.87 Unrealized -41.2%
CHEMOMAB THERAPEUTICS LTD 0.2%
Value ($000) $856 Shares 738,048 Est. Cost $1.57 Unrealized
BMY BRISTOL-MYERS SQUIBB CO 0.2%
Value ($000) $810 Shares 17,500 Est. Cost $52.58 Unrealized -10.2%
CRVS CORVUS PHARMACEUTICALS INC 0.2%
Value ($000) $732 Shares 183,094 Est. Cost $7.47 Unrealized -51.3%
HOWL WEREWOLF THERAPEUTICS INC 0.2%
Value ($000) $683 Shares 626,810 Est. Cost $13.12 Unrealized -92.2%
VSTM VERASTEM INC 0.2%
Value ($000) $678 Shares 163,307 Est. Cost $6.26 Unrealized 0.0%
BCAX BICARA THERAPEUTICS INC 0.1%
Value ($000) $610 Shares 65,679 Est. Cost $11.92 Unrealized 0.0%
LRMR LARIMAR THERAPEUTICS INC 0.1%
Value ($000) $568 Shares 196,635 Est. Cost $7.65 Unrealized -69.7%
S SENTINELONE INC 0.1%
Value ($000) $494 Shares 27,000 Est. Cost $18.29 Unrealized 0.0%
APRE APREA THERAPEUTICS INC 0.1%
Value ($000) $456 Shares 270,000 Est. Cost $6.22 Unrealized -72.6%
CGNT COGNYTE SOFTWARE LTD 0.1%
Value ($000) $417 Shares 45,181 Est. Cost $9.84 Unrealized 0.0%
KZR KEZAR LIFE SCIENCES INC 0.1%
Value ($000) $268 Shares 58,539 Est. Cost $7.45 Unrealized -42.4%
CLYM CLIMB BIO INC 0.1%
Value ($000) $260 Shares 209,837 Est. Cost $5.81 Unrealized -78.6%
SLDB SOLID BIOSCIENCES INC 0.1%
Value ($000) $244 Shares 50,190 Est. Cost $3.54 Unrealized 0.0%
PEPG PEPGEN INC 0.0%
Value ($000) $174 Shares 156,467 Est. Cost $1.41 Unrealized 0.0%
OKUR ONKURE THERAPEUTICS INC 0.0%
Value ($000) $144 Shares 60,454 Est. Cost $15.14 Unrealized -82.7%
ELEVATION ONCOLOGY INC 0.0%
Value ($000) $121 Shares 328,562 Est. Cost $0.88 Unrealized
ELDN ELEDON PHARMACEUTICALS INC 0.0%
Value ($000) $85 Shares 31,200 Est. Cost $3.15 Unrealized -4.8%
JSPR JASPER THERAPEUTICS INC 0.0%
Value ($000) $81 Shares 14,671 Est. Cost $17.76 Unrealized -72.3%
APPLIED THERAPEUTICS INC 0.0%
Value ($000) $16 Shares 50,000 Est. Cost $6.63 Unrealized