SPHERA FUNDS MANAGEMENT LTD. Quant / Systematic

Location: Tel Aviv, Israel

CIK: 0001496201 · Show all filings

Period: Q2 2025 (← Previous) (Next →)

Filing Date: Aug 14, 2025

Total Value: $426M (100.0% shares, 0.0% debt)

Holdings (110)

TEVA TEVA PHARMACEUTICAL INDS LTD 6.4%
Value $27.17M Shares 1,620,990 Est. Cost $15.12 Unrealized
NVMI NOVA LTD 4.9%
Value $20.87M Shares 75,836 Est. Cost $213.92 Unrealized -4.9%
XBI SPDR SERIES TRUST 3.9%
Value $16.59M Shares 200,000 Est. Cost Unrealized
SNDX SYNDAX PHARMACEUTICALS INC 3.5%
Value $14.72M Shares 1,571,564 Est. Cost $17.38 Unrealized -36.7%
TSEM TOWER SEMICONDUCTOR LTD 2.7%
Value $11.48M Shares 264,722 Est. Cost $37.89 Unrealized +1.3%
CYTK CYTOKINETICS INC 2.5%
Value $10.79M Shares 326,718 Est. Cost $40.28 Unrealized -13.7%
SNY SANOFI 2.5%
Value $10.6M Shares 219,515 Est. Cost $46.09 Unrealized
BIIB BIOGEN INC 2.4%
Value $10.39M Shares 82,738 Est. Cost $158.50 Unrealized -21.4%
AZN ASTRAZENECA PLC 2.2%
Value $9.438M Shares 135,060 Est. Cost $54.50 Unrealized
LLY ELI LILLY & CO 2.1%
Value $8.996M Shares 11,540 Est. Cost $258.77 Unrealized +198.9%
NVDA NVIDIA CORPORATION 2.0%
Value $8.613M Shares 54,515 Est. Cost $126.31 Unrealized -0.4%
CLDX CELLDEX THERAPEUTICS INC NEW 2.0%
Value $8.538M Shares 419,540 Est. Cost $32.36 Unrealized -39.9%
NVO NOVO-NORDISK A S 1.7%
Value $7.294M Shares 105,677 Est. Cost $94.01 Unrealized
AMZN AMAZON COM INC 1.7%
Value $7.117M Shares 32,441 Est. Cost $141.58 Unrealized +39.8%
CIDARA THERAPEUTICS INC 1.6%
Value $6.722M Shares 138,001 Est. Cost $45.34 Unrealized
RARE ULTRAGENYX PHARMACEUTICAL IN 1.5%
Value $6.567M Shares 180,600 Est. Cost $46.22 Unrealized -22.0%
ORA ORMAT TECHNOLOGIES INC 1.5%
Value $6.533M Shares 78,000 Est. Cost $76.19 Unrealized -2.2%
MLYS MINERALYS THERAPEUTICS INC 1.5%
Value $6.508M Shares 480,974 Est. Cost $12.16 Unrealized +19.1%
FBRX FORTE BIOSCIENCES INC 1.5%
Value $6.402M Shares 495,109 Est. Cost $8.61 Unrealized 0.0%
META META PLATFORMS INC 1.5%
Value $6.293M Shares 8,526 Est. Cost $353.49 Unrealized +74.4%
JNJ JOHNSON & JOHNSON 1.5%
Value $6.237M Shares 40,831 Est. Cost $136.97 Unrealized +10.1%
MLTX MOONLAKE IMMUNOTHERAPEUTICS 1.4%
Value $5.9M Shares 125,000 Est. Cost Unrealized
MSFT MICROSOFT CORP 1.4%
Value $5.865M Shares 11,792 Est. Cost $379.13 Unrealized +14.0%
FOLD AMICUS THERAPEUTICS INC 1.3%
Value $5.677M Shares 990,718 Est. Cost $6.45 Unrealized 0.0%
ORMAT TECHNOLOGIES INC 1.3%
Value $5.61M Shares 5,037,000 Est. Cost $1.04 Unrealized
PHVS PHARVARIS N V 1.3%
Value $5.455M Shares 309,931 Est. Cost $22.21 Unrealized -27.4%
ELDN ELEDON PHARMACEUTICALS INC 1.2%
Value $5.311M Shares 1,959,610 Est. Cost $3.15 Unrealized -4.8%
TVTX TRAVERE THERAPEUTICS INC 1.2%
Value $4.963M Shares 335,333 Est. Cost $17.24 Unrealized -3.8%
ABBV ABBVIE INC 1.1%
Value $4.688M Shares 25,256 Est. Cost $93.90 Unrealized +94.5%
GSK GSK PLC 1.1%
Value $4.685M Shares 122,000 Est. Cost $35.22 Unrealized
PRAX PRAXIS PRECISION MEDICINES I 1.1%
Value $4.615M Shares 109,757 Est. Cost $51.58 Unrealized -26.2%
NVS NOVARTIS AG 1.1%
Value $4.477M Shares 37,000 Est. Cost $92.00 Unrealized
TRVI TREVI THERAPEUTICS INC 1.0%
Value $4.376M Shares 799,957 Est. Cost $6.22 Unrealized 0.0%
MAZE MAZE THERAPEUTICS INC 1.0%
Value $4.374M Shares 356,453 Est. Cost $12.04 Unrealized -13.6%
ANNX ANNEXON INC 1.0%
Value $4.235M Shares 1,764,387 Est. Cost $5.32 Unrealized -62.3%
PRAX PRAXIS PRECISION MEDICINES I 1.0%
Value $4.205M Shares 100,000 Est. Cost $51.58 Unrealized -26.2%
TLT ISHARES TR 1.0%
Value $4.148M Shares 47,000 Est. Cost Unrealized
IMVT IMMUNOVANT INC 1.0%
Value $4.108M Shares 256,743 Est. Cost $19.52 Unrealized -22.5%
ORIC ORIC PHARMACEUTICALS INC 0.9%
Value $4.006M Shares 394,693 Est. Cost $8.38 Unrealized -19.9%
MRK MERCK & CO INC 0.9%
Value $3.847M Shares 48,600 Est. Cost $73.08 Unrealized +5.9%
ACAD ACADIA PHARMACEUTICALS INC 0.9%
Value $3.773M Shares 174,900 Est. Cost $18.59 Unrealized 0.0%
BBIO BRIDGEBIO PHARMA INC 0.9%
Value $3.761M Shares 87,108 Est. Cost $25.12 Unrealized +44.8%
RARE ULTRAGENYX PHARMACEUTICAL IN 0.9%
Value $3.639M Shares 100,085 Est. Cost $46.22 Unrealized -22.0%
RNAM AVIDITY BIOSCIENCES INC 0.8%
Value $3.578M Shares 126,000 Est. Cost $30.93 Unrealized -3.6%
ACOG ALPHA COGNITION INC 0.8%
Value $3.514M Shares 376,649 Est. Cost $5.61 Unrealized +30.7%
RZLT REZOLUTE INC 0.8%
Value $3.351M Shares 751,447 Est. Cost $3.37 Unrealized +10.1%
HELP CYBIN INC 0.8%
Value $3.342M Shares 398,309 Est. Cost $9.89 Unrealized -26.5%
AMAT APPLIED MATLS INC 0.8%
Value $3.295M Shares 18,000 Est. Cost $166.66 Unrealized -5.5%
ARWR ARROWHEAD PHARMACEUTICALS IN 0.8%
Value $3.207M Shares 202,996 Est. Cost $19.90 Unrealized -27.9%
IMTX IMMATICS N.V 0.7%
Value $3.137M Shares 583,105 Est. Cost $11.13 Unrealized -55.4%
SVRA SAVARA INC 0.7%
Value $2.987M Shares 1,310,233 Est. Cost $3.84 Unrealized -29.3%
UBER UBER TECHNOLOGIES INC 0.7%
Value $2.799M Shares 30,000 Est. Cost $71.41 Unrealized +15.3%
SRPT SAREPTA THERAPEUTICS INC 0.6%
Value $2.724M Shares 159,323 Est. Cost $120.64 Unrealized -64.6%
CAMT CAMTEK LTD 0.6%
Value $2.704M Shares 31,976 Est. Cost $88.36 Unrealized -23.7%
ESLT ELBIT SYS LTD 0.6%
Value $2.697M Shares 6,000 Est. Cost $403.82 Unrealized 0.0%
PANW PALO ALTO NETWORKS INC 0.6%
Value $2.684M Shares 13,114 Est. Cost $185.70 Unrealized 0.0%
WIX WIX COM LTD 0.6%
Value $2.683M Shares 16,931 Est. Cost $141.49 Unrealized +13.8%
AMGN AMGEN INC 0.6%
Value $2.652M Shares 9,500 Est. Cost $287.24 Unrealized -3.3%
SEDG SOLAREDGE TECHNOLOGIES INC 0.6%
Value $2.611M Shares 127,966 Est. Cost $15.39 Unrealized +7.5%
ELVN ENLIVEN THERAPEUTICS INC 0.6%
Value $2.578M Shares 128,515 Est. Cost $21.18 Unrealized -10.6%
SRPT SAREPTA THERAPEUTICS INC 0.6%
Value $2.565M Shares 150,000 Est. Cost $120.64 Unrealized -64.6%
SKYE SKYE BIOSCIENCE INC 0.5%
Value $2.251M Shares 538,434 Est. Cost $10.78 Unrealized -80.8%
BBIO BRIDGEBIO PHARMA INC 0.5%
Value $2.155M Shares 49,900 Est. Cost $25.12 Unrealized +44.8%
DYN DYNE THERAPEUTICS INC 0.5%
Value $2.108M Shares 221,416 Est. Cost $27.02 Unrealized -59.3%
PFE PFIZER INC 0.5%
Value $2.085M Shares 86,000 Est. Cost $36.55 Unrealized -38.9%
BHVN BIOHAVEN LTD 0.5%
Value $2.051M Shares 145,372 Est. Cost $33.08 Unrealized -46.1%
SRRK SCHOLAR ROCK HLDG CORP 0.5%
Value $2.037M Shares 57,497 Est. Cost $8.78 Unrealized +257.5%
89BIO INC 0.5%
Value $2.02M Shares 205,675 Est. Cost $13.61 Unrealized
GPCR STRUCTURE THERAPEUTICS INC 0.5%
Value $1.99M Shares 95,931 Est. Cost $17.74 Unrealized
JANX JANUX THERAPEUTICS INC 0.5%
Value $1.983M Shares 85,840 Est. Cost $45.95 Unrealized -42.7%
APLS APELLIS PHARMACEUTICALS INC 0.5%
Value $1.979M Shares 114,346 Est. Cost $37.03 Unrealized -50.0%
CRM SALESFORCE INC 0.4%
Value $1.854M Shares 6,800 Est. Cost $309.01 Unrealized -13.9%
ENGN ENGENE HOLDINGS INC 0.4%
Value $1.836M Shares 504,409 Est. Cost $7.77 Unrealized -51.7%
CYBERARK SOFTWARE LTD 0.4%
Value $1.628M Shares 4,000 Est. Cost $406.88 Unrealized
MRVL MARVELL TECHNOLOGY INC 0.3%
Value $1.45M Shares 18,730 Est. Cost $67.65 Unrealized -7.9%
COGT COGENT BIOSCIENCES INC 0.3%
Value $1.436M Shares 200,000 Est. Cost $7.84 Unrealized -29.3%
ASTRIA THERAPEUTICS INC 0.3%
Value $1.38M Shares 257,402 Est. Cost $7.84 Unrealized
KURA KURA ONCOLOGY INC 0.3%
Value $1.359M Shares 235,522 Est. Cost $18.44 Unrealized -66.8%
IBIT ISHARES BITCOIN TRUST ETF 0.3%
Value $1.313M Shares 21,455 Est. Cost $55.74 Unrealized
NTLA INTELLIA THERAPEUTICS INC 0.3%
Value $1.208M Shares 128,780 Est. Cost $20.48 Unrealized -59.9%
VTYX VENTYX BIOSCIENCES INC 0.3%
Value $1.189M Shares 555,814 Est. Cost $5.44 Unrealized -70.3%
AMD ADVANCED MICRO DEVICES INC 0.3%
Value $1.171M Shares 8,250 Est. Cost $108.87 Unrealized 0.0%
NNDM NANO DIMENSION LTD 0.3%
Value $1.162M Shares 717,518 Est. Cost $1.59 Unrealized
DAWN DAY ONE BIOPHARMACEUTICALS I 0.3%
Value $1.14M Shares 175,371 Est. Cost $13.06 Unrealized -47.3%
CEVA CEVA INC 0.3%
Value $1.075M Shares 48,920 Est. Cost $32.13 Unrealized -30.8%
CATX PERSPECTIVE THERAPEUTICS INC 0.3%
Value $1.068M Shares 310,343 Est. Cost $14.46 Unrealized -81.7%
COGT COGENT BIOSCIENCES INC 0.2%
Value $1.032M Shares 143,693 Est. Cost $7.84 Unrealized -29.3%
KRYS KRYSTAL BIOTECH INC 0.2%
Value $1.008M Shares 7,335 Est. Cost $146.88 Unrealized 0.0%
TSHA TAYSHA GENE THERAPIES INC 0.2%
Value $970K Shares 420,000 Est. Cost $2.17 Unrealized 0.0%
PROMIS NEUROSCIENCES INC 0.2%
Value $919K Shares 1,899,297 Est. Cost $1.96 Unrealized
VTGN VISTAGEN THERAPEUTICS INC 0.2%
Value $896K Shares 447,939 Est. Cost $3.87 Unrealized -41.2%
CHEMOMAB THERAPEUTICS LTD 0.2%
Value $856K Shares 738,048 Est. Cost $1.57 Unrealized
BMY BRISTOL-MYERS SQUIBB CO 0.2%
Value $810K Shares 17,500 Est. Cost $52.58 Unrealized -10.2%
CRVS CORVUS PHARMACEUTICALS INC 0.2%
Value $732K Shares 183,094 Est. Cost $7.47 Unrealized -51.3%
HOWL WEREWOLF THERAPEUTICS INC 0.2%
Value $683K Shares 626,810 Est. Cost $13.12 Unrealized -92.2%
VSTM VERASTEM INC 0.2%
Value $678K Shares 163,307 Est. Cost $6.26 Unrealized 0.0%
BCAX BICARA THERAPEUTICS INC 0.1%
Value $610K Shares 65,679 Est. Cost $11.92 Unrealized 0.0%
LRMR LARIMAR THERAPEUTICS INC 0.1%
Value $568K Shares 196,635 Est. Cost $7.65 Unrealized -69.7%
S SENTINELONE INC 0.1%
Value $494K Shares 27,000 Est. Cost $18.29 Unrealized 0.0%
APRE APREA THERAPEUTICS INC 0.1%
Value $456K Shares 270,000 Est. Cost $6.22 Unrealized -72.6%
CGNT COGNYTE SOFTWARE LTD 0.1%
Value $417K Shares 45,181 Est. Cost $9.84 Unrealized 0.0%
KZR KEZAR LIFE SCIENCES INC 0.1%
Value $268K Shares 58,539 Est. Cost $7.45 Unrealized -42.4%
CLYM CLIMB BIO INC 0.1%
Value $260K Shares 209,837 Est. Cost $5.81 Unrealized -78.6%
SLDB SOLID BIOSCIENCES INC 0.1%
Value $244K Shares 50,190 Est. Cost $3.54 Unrealized 0.0%
PEPG PEPGEN INC 0.0%
Value $174K Shares 156,467 Est. Cost $1.41 Unrealized 0.0%
OKUR ONKURE THERAPEUTICS INC 0.0%
Value $144K Shares 60,454 Est. Cost $15.14 Unrealized -82.7%
ELEVATION ONCOLOGY INC 0.0%
Value $121K Shares 328,562 Est. Cost $0.88 Unrealized
ELDN ELEDON PHARMACEUTICALS INC 0.0%
Value $84,552 Shares 31,200 Est. Cost $3.15 Unrealized -4.8%
JSPR JASPER THERAPEUTICS INC 0.0%
Value $81,424 Shares 14,671 Est. Cost $17.76 Unrealized -72.3%
APPLIED THERAPEUTICS INC 0.0%
Value $15,555 Shares 50,000 Est. Cost $6.63 Unrealized