| RA CAPITAL MANAGEMENT, L.P. | 63,771,366 | $84,178 |
| BlackRock, Inc. | 45,913,344 | $60,606 |
| VANGUARD GROUP INC | 35,660,969 | $47,072 |
| Deep Track Capital, LP | 32,511,271 | $42,915 |
| Vivo Capital, LLC | 27,225,292 | $35,937 |
| STATE STREET CORP | 26,867,322 | $35,465 |
| Soleus Capital Management, L.P. | 23,290,000 | $30,743 |
| Eversept Partners, LP | 17,659,983 | $23,311 |
| GOLDMAN SACHS GROUP INC | 16,174,398 | $21,350 |
| Clearbridge Investments, LLC | 14,242,953 | $18,801 |
| GEODE CAPITAL MANAGEMENT, LLC | 13,027,335 | $17,199 |
| MORGAN STANLEY | 12,603,418 | $16,637 |
| Vestal Point Capital, LP | 11,320,000 | $14,942 |
| CITADEL ADVISORS LLC | 9,925,786 | $13,102 |
| abrdn plc | 9,527,083 | $12,576 |
| Nantahala Capital Management, LLC | 9,025,000 | $11,913 |
| FMR LLC | 8,076,965 | $10,662 |
| Woodline Partners LP | 7,504,094 | $9,905 |
| DEUTSCHE BANK AG\ | 5,140,809 | $6,786 |
| SEGALL BRYANT & HAMILL, LLC | 5,048,936 | $6,665 |
| Pale Fire Capital SE | 4,788,594 | $6,321 |
| NORTHERN TRUST CORP | 4,726,605 | $6,239 |
| MILLENNIUM MANAGEMENT LLC | 4,603,876 | $6,077 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 4,514,063 | $5,959 |
| ALGERT GLOBAL LLC | 3,499,747 | $5 |
| Kynam Capital Management, LP | 3,456,318 | $4,562 |
| UBS Group AG | 3,273,705 | $4,321 |
| Qube Research & Technologies Ltd | 3,107,529 | $4,102 |
| Candriam S.C.A. | 2,839,484 | $3,748 |
| TWO SIGMA INVESTMENTS, LP | 2,801,468 | $3,698 |
| BANK OF AMERICA CORP /DE/ | 2,698,010 | $3,561 |
| EDMOND DE ROTHSCHILD HOLDING S.A. | 2,330,000 | $3,076 |
| Nuveen, LLC | 1,999,843 | $2,640 |
| BARCLAYS PLC | 1,575,429 | $2,080 |
| Bank of New York Mellon Corp | 1,573,836 | $2,077 |
| Affinity Asset Advisors, LLC | 1,500,000 | $1,980 |
| NAN FUNG TRINITY (HK) LTD | 1,373,550 | $1,813 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,296,163 | $1,711 |
| UBS ASSET MANAGEMENT AMERICAS INC | 1,232,288 | $1,627 |
| Invesco Ltd. | 1,225,658 | $1,618 |
| HRT FINANCIAL LP | 1,200,225 | $2 |
| Squarepoint Ops LLC | 1,130,076 | $1,492 |
| World Investment Advisors | 1,033,779 | $1,365 |
| JANE STREET GROUP, LLC | 1,013,003 | $1,337 |
| Swiss National Bank | 926,100 | $1,222 |
| Almitas Capital LLC | 896,323 | $1,183 |
| WELLS FARGO & COMPANY/MN | 855,141 | $1,129 |
| MML INVESTORS SERVICES, LLC | 834,115 | $1,101 |
| Rafferty Asset Management, LLC | 821,890 | $1,085 |
| Stonepine Capital Management, LLC | 805,800 | $1,064 |
| Seven Fleet Capital Management LP | 777,880 | $1,027 |
| RENAISSANCE TECHNOLOGIES LLC | 737,166 | $973 |
| RHUMBLINE ADVISERS | 727,512 | $960 |
| Centiva Capital, LP | 686,538 | $906 |
| AMERIPRISE FINANCIAL INC | 651,571 | $860 |
| SRS Capital Advisors, Inc. | 627,297 | $828 |
| Lion Point Capital, LP | 578,000 | $763 |
| ALPS ADVISORS INC | 524,159 | $692 |
| Virtus Investment Advisers, LLC | 502,509 | $663 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 475,257 | $627 |
| Legal & General Group Plc | 443,328 | $585 |
| Hennion & Walsh Asset Management, Inc. | 421,458 | $556 |
| Private Advisor Group, LLC | 420,332 | $555 |
| ALLIANCEBERNSTEIN L.P. | 386,341 | $510 |
| TWO SIGMA ADVISERS, LP | 365,046 | $482 |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 364,212 | $452 |
| Inspire Investing, LLC | 354,150 | $467 |
| ADAR1 Capital Management, LLC | 336,176 | $444 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 312,027 | $0 |
| PROFUND ADVISORS LLC | 306,913 | $405 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 301,593 | $399 |
| MetLife Investment Management, LLC | 297,062 | $392 |
| MOODY NATIONAL BANK TRUST DIVISION | 295,425 | $390 |
| JPMORGAN CHASE & CO | 264,478 | $349 |
| XTX Topco Ltd | 258,397 | $341 |
| JANUS HENDERSON GROUP PLC | 239,357 | $317 |
| INTECH INVESTMENT MANAGEMENT LLC | 233,992 | $309 |
| Nvest Financial, LLC | 228,791 | $302 |
| Scientech Research LLC | 227,472 | $300 |
| Russell Investments Group, Ltd. | 225,046 | $297 |
| GROUP ONE TRADING, L.P. | 205,691 | $272 |
| Creative Planning | 203,847 | $269 |
| STATE OF WISCONSIN INVESTMENT BOARD | 202,520 | $267 |
| Cresset Asset Management, LLC | 188,546 | $249 |
| RAYMOND JAMES FINANCIAL INC | 183,366 | $242 |
| Quadrature Capital Ltd | 178,497 | $236 |
| NEW YORK STATE COMMON RETIREMENT FUND | 171,453 | $226 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 166,844 | $220 |
| SG Americas Securities, LLC | 158,787 | $0 |
| Police & Firemen's Retirement System of New Jersey | 153,371 | $202 |
| EntryPoint Capital, LLC | 151,909 | $201 |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 142,122 | $188 |
| CITIGROUP INC | 139,391 | $184 |
| Arizona State Retirement System | 134,936 | $178 |
| LPL Financial LLC | 129,388 | $171 |
| Virtu Financial LLC | 129,333 | $0 |
| ProShare Advisors LLC | 128,026 | $169 |
| Man Group plc | 123,848 | $163 |
| Mason & Associates Inc | 120,700 | $159 |
| HighTower Advisors, LLC | 117,204 | $155 |
| 160 other institutions | 4,423,273 | $5,401 |