Siren, L.L.C. Diversified Active

Location: New York, NY

CIK: 0002005245 · Show all filings

Period: Q1 2026 (← Previous) (Next →)

Filing Date: May 14, 2026

Total Value: $3.607B (100.0% shares, 0.0% debt)

Holdings (100)

SRRK Scholar Rock Holding Corp 14.8%
Value $532M Shares 10,825,013 Est. Cost $12.96 Unrealized +250.9%
KYMR Kymera Therapeutics Inc 7.4%
Value $265M Shares 3,186,830 Est. Cost $43.02 Unrealized +80.4%
ERAS Erasca Inc 5.0%
Value $182M Shares 11,244,246 Est. Cost $4.41 Unrealized +127.3%
EWTX Edgewise Therapeutics Inc 3.9%
Value $140M Shares 4,430,263 Est. Cost $19.44 Unrealized +45.0%
ONC BeOne Medicines AG 3.8%
Value $138M Shares 465,000 Est. Cost $220.70 Unrealized
TNGX Tango Therapeutics Inc 3.3%
Value $118M Shares 5,657,105 Est. Cost $7.74 Unrealized +53.9%
BCAX Bicara Therapeutics Inc 3.2%
Value $115M Shares 5,802,970 Est. Cost $19.85 Unrealized -17.9%
RVMD Revolution Medicines Inc 3.0%
Value $108M Shares 1,110,980 Est. Cost $46.57 Unrealized +121.2%
ARWR Arrowhead Pharmaceuticals Inc 2.8%
Value $101M Shares 1,615,476 Est. Cost $26.81 Unrealized +145.2%
MANE Veradermics Inc 2.6%
Value $95.06M Shares 1,505,374 Est. Cost $63.15 Unrealized
XENE Xenon Pharmaceuticals Inc 2.1%
Value $76.67M Shares 1,318,564 Est. Cost $40.49 Unrealized +3.7%
OLMA Olema Pharmaceuticals Inc 2.0%
Value $70.93M Shares 4,756,949 Est. Cost $20.14 Unrealized +26.4%
CRNX Crinetics Pharmaceuticals Inc 1.9%
Value $69.14M Shares 1,903,636 Est. Cost $51.17 Unrealized -3.8%
LXRX Lexicon Pharmaceuticals Inc 1.9%
Value $69.11M Shares 44,303,518 Est. Cost $1.73 Unrealized -22.0%
COGT Cogent Biosciences Inc 1.8%
Value $65.79M Shares 1,709,279 Est. Cost $10.06 Unrealized +271.3%
STOK Stoke Therapeutics Inc 1.8%
Value $64.97M Shares 1,995,347 Est. Cost $11.96 Unrealized +166.2%
RCUS Arcus Biosciences Inc 1.8%
Value $64.95M Shares 3,007,077 Est. Cost $13.59 Unrealized +56.5%
GPCR Structure Therapeutics Inc 1.8%
Value $64.04M Shares 1,328,698 Est. Cost $33.42 Unrealized
IRON Disc Medicine Inc 1.8%
Value $63.2M Shares 988,401 Est. Cost $57.60 Unrealized +28.6%
RYTM Rhythm Pharmaceuticals Inc 1.7%
Value $63.1M Shares 725,511 Est. Cost $75.89 Unrealized +35.5%
SLDB Solid Biosciences Inc 1.5%
Value $55.37M Shares 7,690,405 Est. Cost $5.85 Unrealized +3.4%
SEPN Septerna Inc 1.3%
Value $48.06M Shares 2,000,000 Est. Cost $23.65 Unrealized +12.1%
CNTA Centessa Pharmaceuticals PLC 1.2%
Value $41.84M Shares 1,053,464 Est. Cost $17.45 Unrealized
SYRE Spyre Therapeutics Inc 1.1%
Value $41.29M Shares 818,598 Est. Cost $27.57 Unrealized +25.3%
CYTK Cytokinetics Inc 1.1%
Value $40.47M Shares 613,952 Est. Cost $64.44 Unrealized 0.0%
DYN Dyne Therapeutics, Inc 1.1%
Value $40.41M Shares 2,229,125 Est. Cost $19.51 Unrealized -12.3%
TSHA Taysha Gene Therapies Inc 1.1%
Value $39.47M Shares 8,829,913 Est. Cost $2.17 Unrealized +119.7%
DBVT Dbv Technologies SA 1.1%
Value $38.8M Shares 1,857,362 Est. Cost $19.17 Unrealized
ORIC Oric Pharmaceuticals Inc 1.1%
Value $37.99M Shares 2,998,192 Est. Cost $10.47 Unrealized +2.8%
ENGN enGene Holdings Inc 1.0%
Value $35.77M Shares 5,253,159 Est. Cost $8.61 Unrealized +12.2%
PVLA Palvella Therapeutics Inc 0.9%
Value $32.1M Shares 257,485 Est. Cost $89.61 Unrealized +2.0%
TBLA Taboola.com Ltd 0.9%
Value $30.91M Shares 9,969,495 Est. Cost $3.30 Unrealized +16.4%
ELVN Enliven Therapeutics Inc 0.8%
Value $29.25M Shares 746,226 Est. Cost $25.60 Unrealized 0.0%
DNLI Denali Therapeutics Inc 0.7%
Value $26.81M Shares 1,396,513 Est. Cost $21.53 Unrealized -8.9%
RELY Remitly Global Inc 0.7%
Value $24.18M Shares 1,543,271 Est. Cost $18.06 Unrealized -22.8%
GLTO Damora Therapeutics Inc 0.6%
Value $23.31M Shares 900,000 Est. Cost $25.80 Unrealized 0.0%
ZURA Zura Bio Ltd 0.6%
Value $22.22M Shares 3,734,866 Est. Cost $5.21 Unrealized +12.9%
ANNX Annexon Inc 0.6%
Value $21.93M Shares 3,958,646 Est. Cost $5.75 Unrealized 0.0%
TRVI Trevi Therapeutics Inc 0.6%
Value $21.32M Shares 1,786,867 Est. Cost $4.03 Unrealized +171.8%
RAPP Rapport Therapeutics Inc 0.6%
Value $20.07M Shares 641,469 Est. Cost $19.15 Unrealized +45.3%
GOOGL Alphabet Inc 0.5%
Value $18.89M Shares 65,703 Est. Cost $277.75 Unrealized +16.4%
FULC Fulcrum Therapeutics Inc 0.5%
Value $18.02M Shares 2,350,000 Est. Cost $10.21 Unrealized +1.6%
WVE WAVE Life Sciences Ltd 0.5%
Value $17.76M Shares 2,450,000 Est. Cost $5.98 Unrealized +130.1%
DFTX Definium Therapeutics Inc 0.5%
Value $17.38M Shares 919,493 Est. Cost $16.29 Unrealized 0.0%
AMLX Amylyx Pharmaceuticals Inc 0.5%
Value $17.1M Shares 1,230,000 Est. Cost $13.99 Unrealized 0.0%
CGEM Cullinan Therapeutics Inc 0.5%
Value $16.96M Shares 1,193,410 Est. Cost $17.74 Unrealized -32.5%
NMRA Neumora Therapeutics Inc 0.5%
Value $16.57M Shares 8,497,822 Est. Cost $7.19 Unrealized -65.7%
QURE Uniqure NV 0.5%
Value $16.35M Shares 1,000,000 Est. Cost $23.55 Unrealized 0.0%
CTMX CytomX Therapeutics Inc 0.5%
Value $16.25M Shares 3,457,711 Est. Cost $5.23 Unrealized 0.0%
NVDA NVIDIA Corp 0.4%
Value $15.54M Shares 89,085 Est. Cost $158.15 Unrealized +18.0%
SLN Silence Therapeutics PLC 0.4%
Value $15.34M Shares 2,911,438 Est. Cost $17.66 Unrealized
MSFT Microsoft Corp 0.4%
Value $15.32M Shares 41,380 Est. Cost $431.05 Unrealized +0.8%
MNPR Monopar Therapeutics Inc 0.4%
Value $14.8M Shares 270,118 Est. Cost $77.66 Unrealized -19.1%
TSM Taiwan Semiconductor Manufacturing Co Ltd 0.4%
Value $14.26M Shares 42,200 Est. Cost $230.16 Unrealized
SION Sionna Therapeutics Inc 0.3%
Value $12.03M Shares 300,000 Est. Cost $16.34 Unrealized +140.2%
NBIS Nebius Group NV 0.3%
Value $11.79M Shares 113,614 Est. Cost $59.72 Unrealized +61.4%
RZLT Rezolute Inc 0.3%
Value $10.15M Shares 3,328,287 Est. Cost $3.06 Unrealized 0.0%
IKT Inhibikase Therapeutics Inc 0.3%
Value $9.828M Shares 5,850,000 Est. Cost $1.59 Unrealized +9.0%
AMZN Amazon.com Inc 0.3%
Value $9.714M Shares 46,641 Est. Cost $196.43 Unrealized +15.5%
GENB Generate Biomedicines Inc 0.3%
Value $9.201M Shares 736,104 Est. Cost $12.50 Unrealized
MPLT MapLight Therapeutics Inc 0.3%
Value $9.149M Shares 450,000 Est. Cost $16.75 Unrealized +5.2%
NOW ServiceNow Inc 0.3%
Value $9.105M Shares 87,090 Est. Cost $142.36 Unrealized -14.9%
CRWD CrowdStrike Holdings Inc 0.2%
Value $9.007M Shares 23,070 Est. Cost $328.72 Unrealized +31.1%
PDD PDD Holdings Inc 0.2%
Value $8.522M Shares 83,401 Est. Cost $117.20 Unrealized
TSLA Tesla Inc 0.2%
Value $7.993M Shares 21,500 Est. Cost $419.51 Unrealized +1.5%
NBP NovaBridge Biosciences 0.2%
Value $7.38M Shares 3,000,000 Est. Cost $3.90 Unrealized
BCYC Bicycle Therapeutics PLC 0.2%
Value $7.242M Shares 1,560,882 Est. Cost $13.30 Unrealized
WHWK Whitehawk Therapeutics Inc 0.2%
Value $7.183M Shares 2,082,000 Est. Cost $2.61 Unrealized +8.0%
TENX Tenax Therapeutics Inc 0.2%
Value $6.83M Shares 427,141 Est. Cost $6.56 Unrealized +105.7%
VTVT vTv Therapeutics Inc 0.2%
Value $6.465M Shares 163,000 Est. Cost $17.30 Unrealized +108.8%
DDOG Datadog Inc 0.2%
Value $6.41M Shares 54,300 Est. Cost $123.86 Unrealized +0.1%
FROG Jfrog Ltd 0.2%
Value $6.045M Shares 128,816 Est. Cost $37.17 Unrealized +42.5%
DT Dynatrace Inc 0.2%
Value $5.547M Shares 150,000 Est. Cost $46.08 Unrealized -16.6%
WK Workiva Inc 0.2%
Value $5.516M Shares 92,500 Est. Cost $84.89 Unrealized -11.9%
ABSI Absci Corp 0.1%
Value $5.4M Shares 1,800,000 Est. Cost $3.00 Unrealized 0.0%
IVVD Invivyd Inc 0.1%
Value $5.2M Shares 4,000,000 Est. Cost $2.08 Unrealized -4.9%
MSLE Satellos Bioscience Inc 0.1%
Value $5.022M Shares 892,074 Est. Cost $5.63 Unrealized
IONQ IONQ Inc 0.1%
Value $4.901M Shares 170,000 Est. Cost $7.62 Unrealized +443.3%
AVGO Broadcom Inc 0.1%
Value $4.643M Shares 15,000 Est. Cost $344.82 Unrealized -3.1%
AGMB Agomab Therapeutics NV 0.1%
Value $4.314M Shares 411,250 Est. Cost $10.49 Unrealized
CLBT Cellebrite DI Ltd 0.1%
Value $4.293M Shares 311,544 Est. Cost $16.47 Unrealized -5.6%
SEER Seer Inc 0.1%
Value $4.131M Shares 2,458,673 Est. Cost $1.75 Unrealized +8.9%
KRRO Korro Bio Inc 0.1%
Value $3.936M Shares 347,718 Est. Cost $42.09 Unrealized -74.4%
AGEN Agenus Inc 0.1%
Value $3.555M Shares 1,064,250 Est. Cost $3.19 Unrealized +2.9%
FHTX Foghorn Therapeutics Inc 0.1%
Value $3.445M Shares 720,720 Est. Cost $7.24 Unrealized -21.4%
FPS Forgent Power Solutions, Inc 0.1%
Value $2.927M Shares 100,000 Est. Cost $29.27 Unrealized
KLRS Kalaris Therapeutics Inc 0.1%
Value $2.515M Shares 435,798 Est. Cost $8.34 Unrealized +12.3%
GTLB GitLab Inc 0.1%
Value $2.164M Shares 100,000 Est. Cost $44.75 Unrealized -26.6%
MU Micron Technology Inc 0.1%
Value $2.027M Shares 6,000 Est. Cost $387.04 Unrealized 0.0%
MNDY monday.com Ltd 0.0%
Value $1.728M Shares 25,000 Est. Cost $166.84 Unrealized -34.4%
GOSS Gossamer Bio Inc 0.0%
Value $1.711M Shares 5,208,968 Est. Cost $0.96 Unrealized +134.6%
AS Amer Sports Inc 0.0%
Value $1.646M Shares 50,000 Est. Cost $38.20 Unrealized 0.0%
BEKE KE Holdings Inc 0.0%
Value $1.497M Shares 100,000 Est. Cost $19.71 Unrealized
IREN IREN Ltd 0.0%
Value $1.477M Shares 43,100 Est. Cost $38.92 Unrealized +24.0%
RANI Rani Therapeutics Holdings Inc 0.0%
Value $1.47M Shares 2,000,000 Est. Cost $1.51 Unrealized -12.3%
AEVA Aeva Technologies Inc 0.0%
Value $1.448M Shares 110,000 Est. Cost $15.02 Unrealized 0.0%
MDLN Medline Inc 0.0%
Value $1.113M Shares 25,000 Est. Cost $42.23 Unrealized +6.2%
FIG Figma Inc 0.0%
Value $1.057M Shares 50,000 Est. Cost $43.84 Unrealized -35.2%
PRMB Primo Brands Corp 0.0%
Value $942K Shares 50,000 Est. Cost $28.92 Unrealized -35.4%
NU Nu Holdings Ltd. 0.0%
Value $359K Shares 25,000 Est. Cost $17.34 Unrealized 0.0%