IONIS PHARMACEUTICALS INC

Ticker: IONS CUSIP: 462222100 Class: COM

Note: Option positions (PUT/CALL) are excluded.

New Positions (92)

Increased Positions (158)

SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC
Value ($000) $115,715 (+135.8%) Shares 1,462,706 (+95.0%)
Artia Global Partners LP
Value ($000) $11,422 (+190.1%) Shares 144,376 (+139.9%)
AlphaCentric Advisors LLC
Value ($000) $1,465 (+450.5%) Shares 18,523 (+143.3%)
BAKER BROS. ADVISORS LP
Value ($000) $141,753 (+282.3%) Shares 1,791,841 (+216.1%)
Future Fund LLC
Value ($000) $3,627 (+53.4%) Shares 45,851 (+26.8%)
Arrowpoint Investment Partners (Singapore) Pte. Ltd.
Value ($000) $1,979 (+453.8%) Shares 25,017 (+357.9%)
GW&K Investment Management, LLC
Value ($000) $62 (+260.3%) Shares 786,668 (+198.0%)
TWO SIGMA ADVISERS, LP
Value ($000) $241,453 (+78.0%) Shares 3,052,111 (+47.2%)
Atika Capital Management LLC
Value ($000) $3,757 (+167.1%) Shares 47,488 (+120.9%)
INCEPTIONR LLC
Value ($000) $1,412 (+183.2%) Shares 17,850 (+134.2%)
TWO SIGMA INVESTMENTS, LP
Value ($000) $210,325 (+104.0%) Shares 2,658,646 (+68.7%)
ADAR1 Capital Management, LLC
Value ($000) $11,639 (+33.0%) Shares 147,130 (+9.9%)
Polar Capital Holdings Plc
Value ($000) $105,487 (+56.0%) Shares 1,333,424 (+29.0%)
Capital World Investors
Value ($000) $1,420,918 (+70.7%) Shares 17,961,299 (+41.2%)
China Universal Asset Management Co., Ltd.
Value ($000) $3,354 (+83.5%) Shares 42,394 (+51.7%)
DAVENPORT & Co LLC
Value ($000) $17,238 (+321.2%) Shares 217,897 (+248.3%)
Connor, Clark & Lunn Investment Management Ltd.
Value ($000) $85,152 (+48.2%) Shares 1,076,370 (+22.6%)
Jain Global LLC
Value ($000) $28,184 (+90.8%) Shares 356,259 (+57.8%)
Alyeska Investment Group, L.P.
Value ($000) $38,108 (+87.1%) Shares 481,711 (+54.8%)
Artisan Partners Limited Partnership
Value ($000) $93,462 (+60.5%) Shares 1,181,416 (+32.7%)

Decreased Positions (133)

Deep Track Capital, LP
Value ($000) $134,487 (-46.0%) Shares 1,700,000 (-55.4%)
Bellevue Group AG
Value ($000) $379,902 (-7.0%) Shares 4,802,199 (-23.1%)
Tweedy, Browne Co LLC
Value ($000) $195,001 (+2.7%) Shares 2,464,930 (-15.0%)
Ikarian Capital, LLC
Value ($000) $15,983 (-41.2%) Shares 202,038 (-51.3%)
SECTOR GAMMA AS
Value ($000) $14,634 (-17.4%) Shares 184,977 (-31.7%)
Rhenman & Partners Asset Management AB
Value ($000) $12,539 (-38.2%) Shares 158,500 (-48.9%)
Exome Asset Management LLC
Value ($000) $9,218 (+7.5%) Shares 116,515 (-11.1%)
Lisanti Capital Growth, LLC
Value ($000) $2,594 (-57.0%) Shares 32,789 (-64.4%)
Privium Fund Management B.V.
Value ($000) $19,052 (+17.0%) Shares 240,824 (-3.2%)
DCF Advisers, LLC
Value ($000) $8,148 (+14.9%) Shares 103,000 (-5.0%)
Cinctive Capital Management LP
Value ($000) $1,086 (-90.5%) Shares 13,726 (-92.1%)
GROUPAMA ASSET MANAGMENT
Value ($000) $60,669 (+62.1%) Shares 766,889 (-27.8%)
Significant Wealth Partners LLC
Value ($000) $535 (-45.4%) Shares 6,764 (-54.8%)
T. Rowe Price Investment Management, Inc.
Value ($000) $458 (-46.8%) Shares 5,789,863 (-56.0%)
BLB&B Advisors, LLC
Value ($000) $4,867 (-37.3%) Shares 61,520 (-48.1%)
ADAGE CAPITAL PARTNERS GP, L.L.C.
Value ($000) $11,075 (-87.1%) Shares 140,000 (-89.4%)
ARK Investment Management LLC
Value ($000) $33,461 (-19.0%) Shares 422,968 (-33.0%)
BOOTHBAY FUND MANAGEMENT, LLC
Value ($000) $5,978 (-44.1%) Shares 75,562 (-53.8%)
DARK FOREST CAPITAL MANAGEMENT LP
Value ($000) $1,004 (-66.7%) Shares 12,691 (-72.5%)
Alpine Global Management, LLC
Value ($000) $4,240 (+16.0%) Shares 53,600 (-4.1%)

Exited Positions (41)