| BlackRock, Inc. | 36,333,325 | $662,720 |
| VANGUARD GROUP INC | 20,854,669 | $380,389 |
| STATE STREET CORP | 13,597,259 | $248,014 |
| Invesco Ltd. | 11,785,202 | $214,962 |
| Sachem Head Capital Management LP | 11,375,000 | $207,480 |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 6,992,907 | $127,551 |
| Capital Research Global Investors | 6,637,472 | $121,067 |
| Nuveen, LLC | 5,926,390 | $108,097 |
| GEODE CAPITAL MANAGEMENT, LLC | 5,830,941 | $106,374 |
| AMERICAN CENTURY COMPANIES INC | 5,198,379 | $94,818 |
| DIMENSIONAL FUND ADVISORS LP | 4,835,638 | $88,204 |
| UBS Group AG | 4,569,343 | $83,345 |
| JANUS HENDERSON GROUP PLC | 3,936,419 | $71,820 |
| Thrivent Financial for Lutherans | 3,790,518 | $69 |
| Caligan Partners LP | 3,012,508 | $54,948 |
| FRANKLIN RESOURCES INC | 2,793,856 | $50,960 |
| B Group, Inc. | 2,457,542 | $44,826 |
| Ranger Investment Management, L.P. | 2,300,905 | $41,969 |
| NORTHERN TRUST CORP | 2,266,890 | $41,348 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 2,257,708 | $41,181 |
| AWM Investment Company, Inc. | 2,200,000 | $40,128 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,160,559 | $39 |
| Fundsmith LLP | 2,102,054 | $38,341 |
| Voya Investment Management LLC | 2,012,096 | $36,701 |
| MORGAN STANLEY | 1,948,373 | $35,538 |
| BANK OF AMERICA CORP /DE/ | 1,926,337 | $35,136 |
| DEUTSCHE BANK AG\ | 1,822,996 | $33,251 |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | 1,550,857 | $28,288 |
| RENAISSANCE TECHNOLOGIES LLC | 1,532,621 | $27,955 |
| CITADEL ADVISORS LLC | 1,522,570 | $27,772 |
| PRINCIPAL FINANCIAL GROUP INC | 1,403,300 | $25,596 |
| Bank of New York Mellon Corp | 1,403,212 | $25,595 |
| MetLife Investment Management, LLC | 1,381,588 | $25,200 |
| PFM Health Sciences, LP | 1,270,894 | $23,181 |
| ROYCE & ASSOCIATES LP | 1,234,467 | $22,517 |
| BNP PARIBAS ARBITRAGE, SA | 1,141,106 | $20,814 |
| NEXT CENTURY GROWTH INVESTORS LLC | 1,100,773 | $20,078 |
| GOLDMAN SACHS GROUP INC | 1,069,525 | $19,508 |
| Russell Investments Group, Ltd. | 1,056,332 | $19,267 |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 1,023,250 | $18,664 |
| RAYMOND JAMES FINANCIAL INC | 1,013,742 | $18,491 |
| abrdn plc | 963,949 | $17,582 |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 890,861 | $16,249 |
| PERCEPTIVE ADVISORS LLC | 883,468 | $16,114 |
| Public Sector Pension Investment Board | 823,688 | $15,024 |
| BOOTHBAY FUND MANAGEMENT, LLC | 788,352 | $14,380 |
| Stonepine Capital Management, LLC | 740,000 | $13,498 |
| KENNEDY CAPITAL MANAGEMENT LLC | 677,600 | $12,359 |
| MILLENNIUM MANAGEMENT LLC | 669,671 | $12,215 |
| Legal & General Group Plc | 663,362 | $12,100 |
| BARCLAYS PLC | 649,100 | $11,840 |
| Holocene Advisors, LP | 629,314 | $11,479 |
| RHUMBLINE ADVISERS | 613,300 | $11,187 |
| Catalio Capital Management, LP | 564,461 | $10,296 |
| D. E. Shaw & Co., Inc. | 557,153 | $10,162 |
| AMERIPRISE FINANCIAL INC | 551,996 | $10,068 |
| TWO SIGMA INVESTMENTS, LP | 504,174 | $9,196 |
| Allspring Global Investments Holdings, LLC | 490,144 | $8,764 |
| RENAISSANCE GROUP LLC | 475,679 | $8,676 |
| PEREGRINE CAPITAL MANAGEMENT LLC | 471,456 | $8,599 |
| Swiss National Bank | 470,600 | $8,584 |
| MARATHON CAPITAL MANAGEMENT | 465,315 | $8,487 |
| JANE STREET GROUP, LLC | 459,424 | $8,380 |
| WELLS FARGO & COMPANY/MN | 411,132 | $7,499 |
| UBS ASSET MANAGEMENT AMERICAS INC | 400,019 | $7,296 |
| Point72 Asset Management, L.P. | 393,879 | $7,184 |
| Chevy Chase Trust Holdings, LLC | 383,635 | $6,998 |
| NEUBERGER BERMAN GROUP LLC | 381,785 | $6,964 |
| Trexquant Investment LP | 370,820 | $6,764 |
| KORNITZER CAPITAL MANAGEMENT INC /KS | 356,867 | $6,509 |
| PRUDENTIAL FINANCIAL INC | 325,350 | $5,934 |
| AQR CAPITAL MANAGEMENT LLC | 306,207 | $5,585 |
| FMR LLC | 302,244 | $5,513 |
| FINDELL CAPITAL MANAGEMENT LLC | 300,000 | $5,472 |
| JPMORGAN CHASE & CO | 299,081 | $5,455 |
| LPL Financial LLC | 296,206 | $5,403 |
| ALLIANCEBERNSTEIN L.P. | 294,583 | $5,373 |
| Calamos Advisors LLC | 292,426 | $5,334 |
| RICE HALL JAMES & ASSOCIATES, LLC | 291,935 | $5,325 |
| Rafferty Asset Management, LLC | 291,161 | $5,311 |
| SEI INVESTMENTS CO | 289,506 | $5,281 |
| Vident Advisory, LLC | 270,492 | $4,934 |
| Duquesne Family Office LLC | 252,200 | $5 |
| Brevan Howard Capital Management LP | 246,772 | $4,501 |
| ALGERT GLOBAL LLC | 236,972 | $4 |
| DekaBank Deutsche Girozentrale | 236,178 | $2 |
| Ikarian Capital, LLC | 234,854 | $4,284 |
| PICTON MAHONEY ASSET MANAGEMENT | 230,816 | $4,210 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 225,136 | $4,106 |
| Homestead Advisers Corp | 220,600 | $4,024 |
| PFG Investments, LLC | 214,001 | $3,903 |
| GREAT WEST LIFE ASSURANCE CO /CAN/ | 206,230 | $4 |
| Parkman Healthcare Partners LLC | 200,000 | $3,648 |
| NEW YORK STATE TEACHERS RETIREMENT SYSTEM | 196,992 | $4 |
| GROUP ONE TRADING, L.P. | 191,264 | $3,489 |
| FEDERATED HERMES, INC. | 189,659 | $3,459 |
| Bridgewater Associates, LP | 186,471 | $3,401 |
| Cetera Investment Advisers | 183,431 | $3,346 |
| BESSEMER GROUP INC | 178,623 | $3 |
| State of Alaska, Department of Revenue | 173,767 | $3 |
| 252 other institutions | 7,360,800 | $123,119 |