| FMR LLC | 5,131,942 | $1,595,572 |
| BlackRock, Inc. | 4,141,230 | $1,287,550 |
| VANGUARD GROUP INC | 3,770,569 | $1,172,308 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,644,094 | $511 |
| STATE STREET CORP | 1,157,417 | $359,853 |
| CITADEL ADVISORS LLC | 990,275 | $307,886 |
| BAILLIE GIFFORD & CO | 876,325 | $272,458 |
| RTW INVESTMENTS, LP | 866,499 | $269,403 |
| JPMORGAN CHASE & CO | 797,490 | $247,948 |
| GEODE CAPITAL MANAGEMENT, LLC | 766,510 | $238,365 |
| Clearbridge Investments, LLC | 690,814 | $214,781 |
| MILLENNIUM MANAGEMENT LLC | 677,832 | $210,745 |
| Invesco Ltd. | 638,305 | $198,455 |
| Champlain Investment Partners, LLC | 601,804 | $187,107 |
| Artisan Partners Limited Partnership | 594,112 | $184,715 |
| MORGAN STANLEY | 525,507 | $163,386 |
| JANUS HENDERSON GROUP PLC | 475,898 | $147,962 |
| Holocene Advisors, LP | 471,348 | $146,547 |
| Capital World Investors | 426,456 | $132,589 |
| CONGRESS ASSET MANAGEMENT CO /MA | 382,350 | $118,876 |
| Allspring Global Investments Holdings, LLC | 358,626 | $110,966 |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 345,974 | $107,567 |
| DIMENSIONAL FUND ADVISORS LP | 324,789 | $100,986 |
| GOLDMAN SACHS GROUP INC | 318,154 | $98,917 |
| NORTHERN TRUST CORP | 310,659 | $96,587 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 307,500 | $95,605 |
| BANK OF AMERICA CORP /DE/ | 306,211 | $95,204 |
| Thrivent Financial for Lutherans | 294,732 | $92 |
| Bank of New York Mellon Corp | 248,656 | $77,309 |
| SAMLYN CAPITAL, LLC | 212,956 | $66,210 |
| Woodline Partners LP | 202,982 | $63,109 |
| FRANKLIN RESOURCES INC | 202,630 | $63,000 |
| AQR CAPITAL MANAGEMENT LLC | 184,941 | $57,500 |
| Jain Global LLC | 183,024 | $56,904 |
| BNP Paribas Investment Partners S.A. | 178,837 | $56 |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 173,846 | $54,050 |
| RAYMOND JAMES FINANCIAL INC | 167,761 | $52,422 |
| BALYASNY ASSET MANAGEMENT L.P. | 161,911 | $50,340 |
| ALLIANCEBERNSTEIN L.P. | 158,301 | $49,217 |
| AMERIPRISE FINANCIAL INC | 155,959 | $48,489 |
| UBS Group AG | 150,372 | $46,752 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 150,000 | $46,637 |
| Baird Financial Group, Inc. | 145,675 | $45,292 |
| Voya Investment Management LLC | 145,457 | $45,224 |
| PFM Health Sciences, LP | 145,171 | $45,135 |
| Bellevue Group AG | 135,395 | $42,096 |
| Stephens Investment Management Group LLC | 120,815 | $37,563 |
| Rock Springs Capital Management LP | 120,500 | $37,465 |
| LORD, ABBETT & CO. LLC | 115,941 | $36 |
| NEW YORK STATE COMMON RETIREMENT FUND | 114,219 | $35,512 |
| WELLINGTON MANAGEMENT GROUP LLP | 113,582 | $35,314 |
| PERCEPTIVE ADVISORS LLC | 110,529 | $34,365 |
| BRAIDWELL LP | 110,152 | $34,247 |
| NZS Capital, LLC | 108,586 | $33,760 |
| RHUMBLINE ADVISERS | 107,162 | $33,318 |
| NORGES BANK | 106,271 | $33,041 |
| MARSHALL WACE, LLP | 105,331 | $32,748 |
| Alyeska Investment Group, L.P. | 101,738 | $31,631 |
| Integral Health Asset Management, LLC | 100,000 | $31,091 |
| Freestone Grove Partners LP | 96,889 | $30,124 |
| LOOMIS SAYLES & CO L P | 93,637 | $29,113 |
| UBS ASSET MANAGEMENT AMERICAS INC | 90,110 | $28,016 |
| SEI INVESTMENTS CO | 88,415 | $27,489 |
| TD Asset Management Inc | 88,154 | $27,408 |
| Amundi | 85,822 | $26,683 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 85,705 | $26,843 |
| PRINCIPAL FINANCIAL GROUP INC | 83,915 | $26,090 |
| Laird Norton Wetherby Trust Company, LLC | 81,385 | $25,303 |
| Point72 Asset Management, L.P. | 80,832 | $25,131 |
| ROYAL BANK OF CANADA | 79,450 | $24,701 |
| Man Group plc | 77,358 | $24,051 |
| Nuveen, LLC | 73,876 | $22,969 |
| VICTORY CAPITAL MANAGEMENT INC | 73,140 | $22,740 |
| Swiss National Bank | 73,020 | $22,703 |
| CARRET ASSET MANAGEMENT, LLC | 72,000 | $22,386 |
| C WorldWide Group Holding A/S | 72,000 | $22 |
| Legal & General Group Plc | 71,675 | $22,284 |
| PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO | 70,252 | $22 |
| Susquehanna Portfolio Strategies, LLC | 66,403 | $20,645 |
| Polar Capital Holdings Plc | 58,168 | $18,085 |
| OSAIC HOLDINGS, INC. | 55,956 | $17,397 |
| Qube Research & Technologies Ltd | 52,540 | $16,335 |
| Vestal Point Capital, LP | 50,000 | $15,546 |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 48,313 | $15,021 |
| NEXT CENTURY GROWTH INVESTORS LLC | 47,830 | $14,871 |
| CITIGROUP INC | 47,650 | $14,815 |
| Retirement Systems of Alabama | 47,002 | $14,613 |
| STATE OF WISCONSIN INVESTMENT BOARD | 46,190 | $14,361 |
| Meridiem Capital Partners LP | 43,249 | $13,447 |
| WCM INVESTMENT MANAGEMENT, LLC | 41,053 | $12,902 |
| NATIXIS ADVISORS, L.P. | 40,772 | $13 |
| NEW YORK STATE TEACHERS RETIREMENT SYSTEM | 38,240 | $12 |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 38,083 | $12 |
| WELLS FARGO & COMPANY/MN | 37,065 | $11,524 |
| ALGERT GLOBAL LLC | 36,905 | $11 |
| ENVESTNET ASSET MANAGEMENT INC | 35,864 | $11,150 |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 35,253 | $10,961 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 35,187 | $10,940 |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 32,642 | $7,558 |
| FIL Ltd | 31,897 | $9,917 |
| 333 other institutions | 1,485,239 | $410,405 |