Siren, L.L.C. Diversified Active

Location: New York, NY

CIK: 0002005245 · Show all filings

Period: Q4 2024 (← Previous) (Next →)

Filing Date: Feb 14, 2025

Total Value: $2.263B (100.0% shares, 0.0% debt)

Holdings (118)

SRRK Scholar Rock Holding Corp 17.7%
Value $400M Shares 9,250,005 Est. Cost $8.78 Unrealized +270.8%
ONC Beigene Ltd 5.3%
Value $121M Shares 653,721 Est. Cost $219.01 Unrealized
KYMR Kymera Therapeutics Inc 5.3%
Value $119M Shares 2,969,733 Est. Cost $44.16 Unrealized +2.3%
APLS Apellis Pharmaceuticals Inc 4.0%
Value $89.87M Shares 2,816,258 Est. Cost $35.43 Unrealized -15.1%
CRNX Crinetics Pharmaceuticals Inc 3.6%
Value $82.3M Shares 1,609,652 Est. Cost $52.39 Unrealized +6.8%
ARGX argenx SE 3.1%
Value $70.75M Shares 115,045 Est. Cost $542.08 Unrealized
BCAX Bicara Therapeutics Inc 2.5%
Value $57.01M Shares 3,272,827 Est. Cost $25.22 Unrealized -17.5%
ARWR Arrowhead Pharmaceuticals Inc 2.4%
Value $54.55M Shares 2,901,681 Est. Cost $23.82 Unrealized -13.6%
NAMS NewAmsterdam Pharma Company NV 2.4%
Value $53.86M Shares 2,095,638 Est. Cost $19.51 Unrealized +8.9%
SEPN Septerna Inc 2.2%
Value $50.44M Shares 2,202,514 Est. Cost $23.65 Unrealized 0.0%
CNTA Centessa Pharmaceuticals PLC 2.2%
Value $50.33M Shares 3,004,677 Est. Cost $15.99 Unrealized
SpringWorks Therapeutics Inc 2.2%
Value $49.78M Shares 1,377,701 Est. Cost $32.04 Unrealized
NMRA Neumora Therapeutics Inc 2.1%
Value $46.6M Shares 4,396,100 Est. Cost $11.80 Unrealized +1.6%
WVE WAVE Life Sciences Ltd 2.0%
Value $46.39M Shares 3,750,491 Est. Cost $5.98 Unrealized +123.3%
ASND Ascendis Pharma A/S 1.8%
Value $40.93M Shares 297,321 Est. Cost $149.31 Unrealized
MDGL Madrigal Pharmaceuticals Inc 1.7%
Value $38.86M Shares 125,942 Est. Cost $281.26 Unrealized 0.0%
TBLA Taboola.com Ltd 1.6%
Value $36.39M Shares 9,969,495 Est. Cost $3.30 Unrealized +8.4%
APGE Apogee Therapeutics Inc 1.5%
Value $33.85M Shares 747,325 Est. Cost $51.00 Unrealized 0.0%
Merus NV 1.5%
Value $32.98M Shares 784,412 Est. Cost $48.93 Unrealized
RNAM Avidity Biosciences Inc 1.4%
Value $32.78M Shares 1,127,295 Est. Cost $43.40 Unrealized -3.7%
VERA Vera Therapeutics Inc 1.4%
Value $32.08M Shares 758,465 Est. Cost $37.95 Unrealized +16.7%
DYN Dyne Therapeutics Inc 1.4%
Value $31.75M Shares 1,347,456 Est. Cost $38.18 Unrealized -22.5%
XENE Xenon Pharmaceuticals Inc 1.3%
Value $29.16M Shares 743,769 Est. Cost $40.32 Unrealized +2.5%
LXRX Lexicon Pharmaceuticals Inc 1.3%
Value $28.8M Shares 38,918,903 Est. Cost $1.78 Unrealized -31.7%
BCYC Bicycle Therapeutics PLC 1.1%
Value $25.75M Shares 1,839,398 Est. Cost $14.00 Unrealized
RVMD Revolution Medicines Inc 1.1%
Value $25M Shares 571,548 Est. Cost $43.54 Unrealized +15.9%
PCVX Vaxcyte Inc 1.1%
Value $24.56M Shares 299,991 Est. Cost $90.12 Unrealized +10.2%
RCUS Arcus Biosciences Inc 1.1%
Value $24M Shares 1,612,077 Est. Cost $15.77 Unrealized +3.6%
ERAS Erasca Inc 1.0%
Value $22.23M Shares 8,857,179 Est. Cost $2.82 Unrealized -2.7%
STOK Stoke Therapeutics Inc 1.0%
Value $22.06M Shares 2,000,000 Est. Cost $12.29 Unrealized 0.0%
IGM Biosciences Inc 0.9%
Value $20.35M Shares 3,330,422 Est. Cost $16.54 Unrealized
EWTX Edgewise Therapeutics Inc 0.9%
Value $19.61M Shares 734,343 Est. Cost $25.27 Unrealized +26.0%
SLN Silence Therapeutics PLC 0.9%
Value $19.48M Shares 2,831,770 Est. Cost $18.18 Unrealized
CYTK Cytokinetics Inc 0.8%
Value $18.93M Shares 402,323 Est. Cost $55.74 Unrealized -6.8%
DNLI Denali Therapeutics Inc 0.8%
Value $17M Shares 834,028 Est. Cost $24.79 Unrealized +3.3%
KRRO Korro Bio Inc 0.7%
Value $15.94M Shares 418,833 Est. Cost $42.09 Unrealized +22.1%
SLNO Soleno Therapeutics Inc 0.7%
Value $15.81M Shares 351,818 Est. Cost $51.81 Unrealized 0.0%
PRTA Prothena Corporation PLC 0.7%
Value $15.23M Shares 1,099,840 Est. Cost $21.50 Unrealized -26.6%
SLDB Solid Biosciences Inc 0.7%
Value $15M Shares 3,749,041 Est. Cost $7.41 Unrealized -25.9%
CGEM Cullinan Therapeutics Inc 0.7%
Value $14.75M Shares 1,211,357 Est. Cost $17.74 Unrealized -19.0%
UPB Upstream Bio Inc 0.6%
Value $13.15M Shares 800,000 Est. Cost $22.33 Unrealized 0.0%
TRVI Trevi Therapeutics Inc 0.5%
Value $11.97M Shares 2,906,060 Est. Cost $3.20 Unrealized 0.0%
KURA Kura Oncology Inc 0.5%
Value $11.67M Shares 1,339,942 Est. Cost $20.26 Unrealized -29.0%
TSHA Taysha Gene Therapies Inc 0.5%
Value $11.42M Shares 6,602,475 Est. Cost $2.16 Unrealized -4.1%
RELY Remitly Global Inc 0.5%
Value $11.07M Shares 490,449 Est. Cost $18.16 Unrealized +1.4%
RNAC Cartesian Therapeutics Inc 0.5%
Value $10.25M Shares 572,236 Est. Cost $15.62 Unrealized +29.6%
MSFT Microsoft Corp 0.4%
Value $9.694M Shares 23,000 Est. Cost $423.07 Unrealized -0.2%
JANX Janux Therapeutics Inc 0.4%
Value $9.37M Shares 175,000 Est. Cost $52.89 Unrealized 0.0%
SEER Seer Inc 0.4%
Value $9.24M Shares 4,000,000 Est. Cost $1.75 Unrealized +25.1%
IONS Ionis Pharmaceuticals Inc 0.4%
Value $8.74M Shares 250,000 Est. Cost $46.53 Unrealized -19.7%
SYRE Spyre Therapeutics Inc 0.4%
Value $8.707M Shares 374,000 Est. Cost $29.32 Unrealized 0.0%
CRWD CrowdStrike Holdings Inc 0.4%
Value $8.212M Shares 24,000 Est. Cost $284.07 Unrealized +17.1%
IOVA Iovance Biotherapeutics Inc 0.4%
Value $8.185M Shares 1,106,040 Est. Cost $9.47 Unrealized -2.2%
ORIC Oric Pharmaceuticals Inc 0.4%
Value $8.131M Shares 1,007,575 Est. Cost $9.89 Unrealized -7.2%
TNGX Tango Therapeutics Inc 0.4%
Value $8.046M Shares 2,603,897 Est. Cost $9.54 Unrealized -51.3%
AMZN Amazon.com Inc 0.4%
Value $8.008M Shares 36,500 Est. Cost $183.52 Unrealized +11.5%
RCKT Rocket Pharmaceuticals Inc 0.3%
Value $7.542M Shares 600,000 Est. Cost $15.05 Unrealized 0.0%
IONQ IONQ Inc 0.3%
Value $7.101M Shares 170,000 Est. Cost $7.62 Unrealized +229.0%
IHS IHS Holding Limited 0.3%
Value $6.884M Shares 2,357,520 Est. Cost $3.08 Unrealized -1.4%
RAPP Rapport Therapeutics Inc 0.3%
Value $6.816M Shares 384,197 Est. Cost $21.49 Unrealized +3.1%
NVDA NVIDIA Corp 0.3%
Value $6.571M Shares 48,932 Est. Cost $118.07 Unrealized +16.7%
NOW ServiceNow Inc 0.3%
Value $5.942M Shares 5,605 Est. Cost $164.40 Unrealized +23.2%
ACELYRIN Inc 0.2%
Value $5.431M Shares 1,729,665 Est. Cost $4.93 Unrealized
PDD PDD Holdings Inc 0.2%
Value $5.131M Shares 52,901 Est. Cost $125.87 Unrealized
GOSS Gossamer Bio Inc 0.2%
Value $4.712M Shares 5,208,968 Est. Cost $0.96 Unrealized -10.9%
DT Dynatrace Inc 0.2%
Value $4.496M Shares 82,729 Est. Cost $47.61 Unrealized +14.6%
BA Boeing Co 0.2%
Value $4.425M Shares 25,000 Est. Cost $156.93 Unrealized 0.0%
EDU New Oriental Education & Technology Group Inc 0.2%
Value $4.396M Shares 68,500 Est. Cost $70.73 Unrealized
DDOG Datadog Inc 0.2%
Value $4.347M Shares 30,425 Est. Cost $116.83 Unrealized +17.6%
PRQR ProQR Therapeutics NV 0.2%
Value $4.174M Shares 1,575,000 Est. Cost $3.18 Unrealized 0.0%
LXEO Lexeo Therapeutics Inc 0.2%
Value $3.971M Shares 603,435 Est. Cost $11.93 Unrealized -34.0%
ADBE Adobe Inc 0.2%
Value $3.912M Shares 8,798 Est. Cost $501.19 Unrealized -1.2%
PHAT Phathom Pharmaceuticals Inc 0.2%
Value $3.741M Shares 460,753 Est. Cost $13.98 Unrealized -11.4%
TIL Instil Bio Inc 0.2%
Value $3.674M Shares 192,433 Est. Cost $23.54 Unrealized +29.5%
FROG Jfrog Ltd 0.2%
Value $3.533M Shares 120,116 Est. Cost $30.89 Unrealized -1.7%
FHTX Foghorn Therapeutics Inc. 0.2%
Value $3.402M Shares 720,720 Est. Cost $7.24 Unrealized +0.6%
Vigil Neuroscience Inc 0.1%
Value $3.385M Shares 1,991,038 Est. Cost $3.40 Unrealized
NBIS Nebius Group NV 0.1%
Value $3.324M Shares 120,000 Est. Cost $24.38 Unrealized 0.0%
SGMT Sagimet Biosciences Inc 0.1%
Value $3.261M Shares 724,771 Est. Cost $3.08 Unrealized +64.4%
Generation Bio Co 0.1%
Value $3.162M Shares 2,982,733 Est. Cost $2.47 Unrealized
TSM Taiwan Semiconductor Manufacturing Co Ltd 0.1%
Value $2.962M Shares 15,000 Est. Cost $173.67 Unrealized
FCX Freeport-McMoRan Inc 0.1%
Value $2.856M Shares 75,000 Est. Cost $44.04 Unrealized 0.0%
Allovir Inc 0.1%
Value $2.771M Shares 6,597,167 Est. Cost $0.81 Unrealized
OVID Ovid Therapeutics Inc 0.1%
Value $2.661M Shares 2,850,000 Est. Cost $1.04 Unrealized +7.1%
SE Sea Ltd 0.1%
Value $2.652M Shares 25,000 Est. Cost $94.28 Unrealized
ESTC Elastic NV 0.1%
Value $2.477M Shares 25,000 Est. Cost $95.66 Unrealized -3.4%
QCOM Qualcomm Inc 0.1%
Value $2.304M Shares 15,000 Est. Cost $171.16 Unrealized -6.8%
BIOA BIOAGE Labs Inc 0.1%
Value $2.247M Shares 388,000 Est. Cost $19.40 Unrealized -11.1%
BDTX Black Diamond Therapeutics Inc 0.1%
Value $2.24M Shares 1,046,517 Est. Cost $5.44 Unrealized -47.3%
RGNX Regenxbio Inc 0.1%
Value $2.195M Shares 284,000 Est. Cost $12.19 Unrealized -23.0%
Tourmaline Bio Inc 0.1%
Value $1.854M Shares 91,426 Est. Cost $25.71 Unrealized
PCOR Procore Technologies Inc 0.1%
Value $1.499M Shares 20,000 Est. Cost $61.37 Unrealized +15.6%
Applied Therapeutics Inc 0.1%
Value $1.399M Shares 1,633,768 Est. Cost $8.50 Unrealized
GOOGL Alphabet Inc 0.1%
Value $1.325M Shares 7,000 Est. Cost $166.73 Unrealized +4.4%
PYPL PayPal Holdings Inc 0.1%
Value $1.28M Shares 15,000 Est. Cost $66.73 Unrealized +25.7%
HOOK HOOKIPA Pharma Inc 0.1%
Value $1.139M Shares 566,640 Est. Cost $5.28 Unrealized -41.4%
HCA HCA Healthcare Inc 0.0%
Value $1.126M Shares 3,750 Est. Cost $346.27 Unrealized 0.0%
BEKE Ke Holdings Inc 0.0%
Value $1.105M Shares 60,000 Est. Cost $19.91 Unrealized
WK Workiva Inc 0.0%
Value $1.095M Shares 10,000 Est. Cost $92.18 Unrealized 0.0%
PANW Palo Alto Networks Inc 0.0%
Value $1.092M Shares 6,000 Est. Cost $173.46 Unrealized +8.9%
Omega Therapeutics Inc 0.0%
Value $987K Shares 1,323,530 Est. Cost $1.22 Unrealized
Couchbase Inc 0.0%
Value $935K Shares 60,000 Est. Cost $15.59 Unrealized
Achilles Therapeutics PLC 0.0%
Value $861K Shares 755,375 Est. Cost $1.02 Unrealized
RACE Ferrari NV 0.0%
Value $854K Shares 2,000 Est. Cost $451.22 Unrealized 0.0%
INTC Intel Corp 0.0%
Value $802K Shares 40,000 Est. Cost $24.89 Unrealized -9.4%
Kronos Bio Inc 0.0%
Value $801K Shares 842,954 Est. Cost $1.00 Unrealized
DLTR Dollar Tree Inc 0.0%
Value $749K Shares 10,000 Est. Cost $91.18 Unrealized -24.7%
OXY Occidental Petroleum Corp 0.0%
Value $741K Shares 15,000 Est. Cost $55.40 Unrealized -11.1%
META Meta Platforms Inc 0.0%
Value $586K Shares 1,000 Est. Cost $512.12 Unrealized +14.2%
MRVL Marvell Technology Inc 0.0%
Value $552K Shares 5,000 Est. Cost $92.47 Unrealized 0.0%
NU Nu Holdings Ltd 0.0%
Value $518K Shares 50,000 Est. Cost $13.45 Unrealized -1.1%
IRWD Ironwood Pharmaceuticals Inc 0.0%
Value $490K Shares 110,532 Est. Cost $5.38 Unrealized -24.5%
MNDY Monday.Com Ltd 0.0%
Value $471K Shares 2,000 Est. Cost $277.00 Unrealized 0.0%
SEMR SEMrush Holdings Inc 0.0%
Value $416K Shares 35,000 Est. Cost $13.43 Unrealized 0.0%
CYCN Cyclerion Therapeutics Inc 0.0%
Value $374K Shares 116,155 Est. Cost $2.94 Unrealized -5.2%
BZ Kanzhun Ltd 0.0%
Value $345K Shares 25,000 Est. Cost $17.36 Unrealized
GOSS Gossamer Bio Inc 0.0%
Value $187K Shares 207,000 Est. Cost $0.96 Unrealized -10.9%
CRBU Caribou Biosciences Inc 0.0%
Value $168K Shares 105,347 Est. Cost $2.05 Unrealized -1.8%