Siren, L.L.C. Diversified Active

Location: New York, NY

CIK: 0002005245 · Show all filings

Period: Q1 2025 (← Previous) (Next →)

Filing Date: May 23, 2025

Total Value: $1.773B (100.0% shares, 0.0% debt)

Holdings (116)

SRRK Scholar Rock Holding Corp 16.8%
Value $297M Shares 9,250,005 Est. Cost $8.78 Unrealized +338.1%
ONC Beigene Ltd 7.7%
Value $136M Shares 498,689 Est. Cost $219.01 Unrealized
KYMR Kymera Therapeutics Inc 5.0%
Value $88.69M Shares 3,240,313 Est. Cost $43.52 Unrealized -16.2%
Blueprint Medicines Corp 3.6%
Value $64.27M Shares 726,167 Est. Cost $88.51 Unrealized
CRNX Crinetics Pharmaceuticals Inc 3.2%
Value $56.64M Shares 1,688,611 Est. Cost $51.69 Unrealized -27.7%
APLS Apellis Pharmaceuticals Inc 3.2%
Value $56.39M Shares 2,578,396 Est. Cost $35.43 Unrealized -22.0%
IRON Disc Medicine Inc 3.0%
Value $53.21M Shares 1,071,865 Est. Cost $55.60 Unrealized 0.0%
SLNO Soleno Therapeutics Inc 2.9%
Value $51.97M Shares 727,337 Est. Cost $50.20 Unrealized -3.0%
ASND Ascendis Pharma A/S 2.5%
Value $44.79M Shares 287,366 Est. Cost $149.31 Unrealized
Merus NV 2.5%
Value $43.92M Shares 1,043,467 Est. Cost $47.23 Unrealized
BCAX Bicara Therapeutics Inc 2.4%
Value $42.57M Shares 3,267,083 Est. Cost $25.22 Unrealized -47.3%
CNTA Centessa Pharmaceuticals PLC 2.4%
Value $42.57M Shares 2,960,029 Est. Cost $15.99 Unrealized
NAMS NewAmsterdam Pharma Company NV 2.2%
Value $39.14M Shares 1,912,030 Est. Cost $19.51 Unrealized +13.9%
EWTX Edgewise Therapeutics Inc 2.1%
Value $37.32M Shares 1,696,444 Est. Cost $25.81 Unrealized +1.6%
ARWR Arrowhead Pharmaceuticals Inc 1.9%
Value $34.01M Shares 2,669,880 Est. Cost $23.82 Unrealized -23.7%
RNAM Avidity Biosciences Inc 1.8%
Value $32.79M Shares 1,110,610 Est. Cost $43.40 Unrealized -28.2%
WVE WAVE Life Sciences Ltd 1.7%
Value $29.87M Shares 3,696,322 Est. Cost $5.98 Unrealized +83.0%
TBLA Taboola.com Ltd 1.7%
Value $29.41M Shares 9,969,495 Est. Cost $3.30 Unrealized +3.7%
DYN Dyne Therapeutics Inc 1.6%
Value $28.43M Shares 2,717,987 Est. Cost $26.14 Unrealized -45.3%
SLDB Solid Biosciences Inc 1.5%
Value $27.44M Shares 7,415,905 Est. Cost $5.86 Unrealized -27.0%
XENE Xenon Pharmaceuticals Inc 1.4%
Value $24.58M Shares 732,761 Est. Cost $40.32 Unrealized -5.8%
APGE Apogee Therapeutics Inc 1.3%
Value $22.23M Shares 594,994 Est. Cost $51.00 Unrealized -24.2%
RVMD Revolution Medicines Inc 1.1%
Value $19.93M Shares 563,755 Est. Cost $43.54 Unrealized -6.8%
TRVI Trevi Therapeutics Inc 1.0%
Value $18.01M Shares 2,863,793 Est. Cost $3.20 Unrealized +49.0%
VERA Vera Therapeutics Inc 1.0%
Value $17.95M Shares 747,216 Est. Cost $37.95 Unrealized -15.3%
LXRX Lexicon Pharmaceuticals Inc 1.0%
Value $17.93M Shares 38,918,903 Est. Cost $1.78 Unrealized -64.5%
PRTA Prothena Corporation PLC 0.9%
Value $15.88M Shares 1,283,555 Est. Cost $20.45 Unrealized -30.8%
BCYC Bicycle Therapeutics PLC 0.9%
Value $15.39M Shares 1,812,752 Est. Cost $14.00 Unrealized
STOK Stoke Therapeutics Inc 0.8%
Value $14.94M Shares 2,247,347 Est. Cost $11.96 Unrealized -22.0%
RYTM Rhythm Pharmaceuticals Inc 0.8%
Value $14.7M Shares 277,533 Est. Cost $55.48 Unrealized 0.0%
SMMT Summit Therapeutics Inc 0.8%
Value $13.41M Shares 695,000 Est. Cost $20.06 Unrealized 0.0%
SEPN Septerna Inc 0.7%
Value $12.75M Shares 2,202,514 Est. Cost $23.65 Unrealized -51.7%
RCUS Arcus Biosciences Inc 0.7%
Value $12.65M Shares 1,612,077 Est. Cost $15.77 Unrealized -26.5%
IHS IHS Holding Limited 0.7%
Value $12.31M Shares 2,357,520 Est. Cost $3.08 Unrealized +24.6%
ERAS Erasca Inc 0.7%
Value $12M Shares 8,757,249 Est. Cost $2.82 Unrealized -39.1%
DNLI Denali Therapeutics Inc 0.6%
Value $11.17M Shares 821,513 Est. Cost $24.79 Unrealized -22.7%
PCVX Vaxcyte Inc 0.6%
Value $11.16M Shares 295,543 Est. Cost $90.12 Unrealized -11.3%
AMZN Amazon.com Inc 0.6%
Value $10.75M Shares 56,500 Est. Cost $195.37 Unrealized +11.1%
MSFT Microsoft Corp 0.6%
Value $10.7M Shares 28,500 Est. Cost $419.60 Unrealized -3.5%
RELY Remitly Global Inc 0.6%
Value $10.2M Shares 490,449 Est. Cost $18.16 Unrealized +26.3%
TSHA Taysha Gene Therapies Inc 0.5%
Value $9.055M Shares 6,514,737 Est. Cost $2.16 Unrealized -22.7%
CGEM Cullinan Therapeutics Inc 0.5%
Value $9.034M Shares 1,193,410 Est. Cost $17.74 Unrealized -45.9%
CRWD CrowdStrike Holdings Inc 0.5%
Value $8.815M Shares 25,000 Est. Cost $287.95 Unrealized +32.3%
SLN Silence Therapeutics PLC 0.4%
Value $7.867M Shares 2,789,833 Est. Cost $18.18 Unrealized
GOOGL Alphabet Inc 0.4%
Value $7.841M Shares 50,703 Est. Cost $178.77 Unrealized +1.1%
RNAC Cartesian Therapeutics Inc 0.4%
Value $7.424M Shares 563,272 Est. Cost $15.62 Unrealized +14.3%
ADBE Adobe Inc 0.4%
Value $7.401M Shares 19,298 Est. Cost $461.82 Unrealized -7.1%
KRRO Korro Bio Inc 0.4%
Value $7.292M Shares 418,833 Est. Cost $42.09 Unrealized -29.5%
NOW ServiceNow Inc 0.4%
Value $7.266M Shares 9,126 Est. Cost $175.34 Unrealized +9.9%
SEER Seer Inc 0.4%
Value $6.76M Shares 4,000,000 Est. Cost $1.75 Unrealized +24.2%
PDD PDD Holdings Inc 0.4%
Value $6.261M Shares 52,901 Est. Cost $125.87 Unrealized
SYRE Spyre Therapeutics Inc 0.3%
Value $5.947M Shares 368,598 Est. Cost $29.32 Unrealized -29.0%
GOSS Gossamer Bio Inc 0.3%
Value $5.73M Shares 5,208,968 Est. Cost $0.96 Unrealized +20.2%
ORIC Oric Pharmaceuticals Inc 0.3%
Value $5.622M Shares 1,007,575 Est. Cost $9.89 Unrealized -11.6%
UPB Upstream Bio Inc 0.3%
Value $4.825M Shares 788,450 Est. Cost $22.33 Unrealized -57.2%
NVDA NVIDIA Corp 0.3%
Value $4.816M Shares 44,432 Est. Cost $118.07 Unrealized +7.3%
TSM Taiwan Semiconductor Manufacturing Co Ltd 0.3%
Value $4.731M Shares 28,500 Est. Cost $170.04 Unrealized
DDOG Datadog Inc 0.3%
Value $4.705M Shares 47,425 Est. Cost $120.18 Unrealized +5.0%
NMRA Neumora Therapeutics Inc 0.2%
Value $4.358M Shares 4,358,283 Est. Cost $11.80 Unrealized -85.5%
FROG Jfrog Ltd 0.2%
Value $4.212M Shares 131,616 Est. Cost $31.23 Unrealized +11.5%
DT Dynatrace Inc 0.2%
Value $4.136M Shares 87,729 Est. Cost $48.01 Unrealized +13.9%
Metsera Inc 0.2%
Value $4.083M Shares 150,000 Est. Cost $27.22 Unrealized
RCKT Rocket Pharmaceuticals Inc 0.2%
Value $3.944M Shares 591,263 Est. Cost $15.05 Unrealized -34.4%
CRM Salesforce Inc 0.2%
Value $3.918M Shares 14,600 Est. Cost $309.01 Unrealized 0.0%
EDU New Oriental Education & Technology Group Inc 0.2%
Value $3.801M Shares 79,500 Est. Cost $67.56 Unrealized
RAPP Rapport Therapeutics Inc 0.2%
Value $3.796M Shares 378,469 Est. Cost $21.49 Unrealized -39.6%
IONQ IONQ Inc 0.2%
Value $3.752M Shares 170,000 Est. Cost $7.62 Unrealized +325.1%
IGM Biosciences Inc 0.2%
Value $3.744M Shares 3,255,826 Est. Cost $16.54 Unrealized
WHWK Whitehawk Therapeutics Inc 0.2%
Value $3.706M Shares 2,082,000 Est. Cost $2.61 Unrealized 0.0%
TIL Instil Bio Inc 0.2%
Value $3.54M Shares 203,933 Est. Cost $23.39 Unrealized -11.3%
TNGX Tango Therapeutics Inc 0.2%
Value $3.515M Shares 2,565,342 Est. Cost $9.54 Unrealized -74.3%
Vigil Neuroscience Inc 0.2%
Value $3.501M Shares 1,967,064 Est. Cost $3.40 Unrealized
SION Sionna Therapeutics Inc 0.2%
Value $3.4M Shares 325,000 Est. Cost $16.34 Unrealized 0.0%
NBIS Nebius Group NV 0.2%
Value $2.955M Shares 140,000 Est. Cost $25.60 Unrealized +28.5%
FHTX Foghorn Therapeutics Inc. 0.1%
Value $2.631M Shares 720,720 Est. Cost $7.24 Unrealized -37.0%
RDDT Reddit Inc 0.1%
Value $2.465M Shares 23,500 Est. Cost $165.28 Unrealized 0.0%
LPLA LPL Financial Holdings Inc 0.1%
Value $2.454M Shares 7,500 Est. Cost $348.21 Unrealized 0.0%
SGMT Sagimet Biosciences Inc 0.1%
Value $2.363M Shares 724,771 Est. Cost $3.08 Unrealized +36.1%
ELDN Eledon Pharmaceuticals Inc 0.1%
Value $2.34M Shares 690,170 Est. Cost $4.12 Unrealized 0.0%
TSLA Tesla Inc 0.1%
Value $2.332M Shares 9,000 Est. Cost $333.26 Unrealized 0.0%
KLRS Kalaris Therapeutics Inc 0.1%
Value $2.269M Shares 282,586 Est. Cost $9.79 Unrealized 0.0%
MRVL Marvell Technology Inc 0.1%
Value $2.266M Shares 36,808 Est. Cost $96.12 Unrealized +0.6%
QCOM Qualcomm Inc 0.1%
Value $2.151M Shares 14,000 Est. Cost $171.16 Unrealized -6.7%
BEKE Ke Holdings Inc 0.1%
Value $2.109M Shares 105,000 Est. Cost $19.99 Unrealized
LXEO Lexeo Therapeutics Inc 0.1%
Value $2.094M Shares 603,435 Est. Cost $11.93 Unrealized -62.9%
PRQR ProQR Therapeutics NV 0.1%
Value $2.064M Shares 1,552,183 Est. Cost $3.18 Unrealized -33.0%
PANW Palo Alto Networks Inc 0.1%
Value $1.962M Shares 11,500 Est. Cost $178.94 Unrealized +3.3%
SAIL SailPoint Inc 0.1%
Value $1.781M Shares 95,000 Est. Cost $21.79 Unrealized 0.0%
BDTX Black Diamond Therapeutics Inc 0.1%
Value $1.622M Shares 1,046,517 Est. Cost $5.44 Unrealized -61.5%
SARO StandardAero, Inc. 0.1%
Value $1.515M Shares 56,855 Est. Cost $26.66 Unrealized 0.0%
BIOA BIOAGE Labs Inc 0.1%
Value $1.438M Shares 382,406 Est. Cost $19.40 Unrealized -76.2%
Tourmaline Bio Inc 0.1%
Value $1.391M Shares 91,426 Est. Cost $25.71 Unrealized
WK Workiva Inc 0.1%
Value $1.328M Shares 17,500 Est. Cost $93.15 Unrealized +1.4%
BILL BILL Holdings Inc 0.1%
Value $1.308M Shares 28,500 Est. Cost $67.25 Unrealized 0.0%
PYPL PayPal Holdings Inc 0.1%
Value $1.305M Shares 20,000 Est. Cost $69.48 Unrealized +11.9%
Generation Bio Co 0.1%
Value $1.202M Shares 2,968,925 Est. Cost $2.47 Unrealized
SEMR SEMrush Holdings Inc 0.1%
Value $1.166M Shares 125,000 Est. Cost $13.58 Unrealized +0.4%
PEGA Pegasystems Inc 0.1%
Value $1.147M Shares 16,500 Est. Cost $44.23 Unrealized 0.0%
MDB MongoDB Inc 0.1%
Value $965K Shares 5,500 Est. Cost $243.68 Unrealized 0.0%
NKE Nike Inc 0.1%
Value $952K Shares 15,000 Est. Cost $72.05 Unrealized 0.0%
INTC Intel Corp 0.1%
Value $908K Shares 40,000 Est. Cost $24.89 Unrealized -12.1%
Informatica Inc 0.0%
Value $873K Shares 50,000 Est. Cost $17.45 Unrealized
BA Boeing Co 0.0%
Value $853K Shares 5,000 Est. Cost $156.93 Unrealized +10.3%
Couchbase Inc 0.0%
Value $785K Shares 49,850 Est. Cost $15.59 Unrealized
AGEN Agenus Inc 0.0%
Value $753K Shares 500,000 Est. Cost $2.88 Unrealized 0.0%
Kronos Bio Inc 0.0%
Value $695K Shares 842,954 Est. Cost $1.00 Unrealized
PCOR Procore Technologies Inc 0.0%
Value $660K Shares 10,000 Est. Cost $61.37 Unrealized +23.0%
RACE Ferrari NV 0.0%
Value $636K Shares 1,500 Est. Cost $451.22 Unrealized -0.3%
HOOK HOOKIPA Pharma Inc 0.0%
Value $612K Shares 566,640 Est. Cost $5.28 Unrealized -68.8%
DECK Deckers Outdoor Corp 0.0%
Value $559K Shares 5,000 Est. Cost $161.52 Unrealized 0.0%
USB US Bancorp 0.0%
Value $528K Shares 12,500 Est. Cost $44.20 Unrealized 0.0%
OXY Occidental Petroleum Corp 0.0%
Value $494K Shares 10,000 Est. Cost $55.40 Unrealized -13.6%
GDS GDS Holdings Ltd 0.0%
Value $317K Shares 12,500 Est. Cost $25.33 Unrealized
CYCN Cyclerion Therapeutics Inc 0.0%
Value $290K Shares 116,155 Est. Cost $2.94 Unrealized +1.4%
IRWD Ironwood Pharmaceuticals Inc 0.0%
Value $162K Shares 110,532 Est. Cost $5.38 Unrealized -55.7%
CRBU Caribou Biosciences Inc 0.0%
Value $96,192 Shares 105,347 Est. Cost $2.05 Unrealized -36.5%