| BlackRock, Inc. | 8,875,194 | $168,362 |
| Redmile Group, LLC | 8,093,908 | $153,541 |
| Deep Track Capital, LP | 7,036,455 | $133,482 |
| VANGUARD GROUP INC | 5,949,512 | $112,862 |
| GENERAL ATLANTIC, L.P. | 4,897,159 | $92,899 |
| MORGAN STANLEY | 4,881,069 | $92,594 |
| Vestal Point Capital, LP | 4,690,000 | $88,969 |
| BAKER BROS. ADVISORS LP | 4,658,556 | $88,373 |
| FMR LLC | 4,234,158 | $80,322 |
| STATE STREET CORP | 3,559,501 | $67,524 |
| PERCEPTIVE ADVISORS LLC | 3,555,877 | $67,455 |
| Pictet Asset Management Holding SA | 3,467,600 | $65,780 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,248,361 | $62 |
| Point72 Asset Management, L.P. | 3,211,680 | $60,926 |
| DEUTSCHE BANK AG\ | 2,486,792 | $47,174 |
| Rubric Capital Management LP | 2,473,885 | $46,930 |
| GEODE CAPITAL MANAGEMENT, LLC | 2,384,998 | $45,250 |
| Commodore Capital LP | 2,275,000 | $43,157 |
| BRAIDWELL LP | 2,183,864 | $41,428 |
| Kynam Capital Management, LP | 1,970,357 | $37,378 |
| Trails Edge Capital Partners, LP | 1,743,220 | $33,069 |
| ARK Investment Management LLC | 1,602,539 | $30,400 |
| EVENTIDE ASSET MANAGEMENT, LLC | 1,297,893 | $24,621 |
| Sumitomo Mitsui Trust Holdings, Inc. | 1,290,554 | $24,482 |
| Nikko Asset Management Americas, Inc. | 1,290,554 | $24,482 |
| Soleus Capital Management, L.P. | 1,219,394 | $23,132 |
| CITADEL ADVISORS LLC | 1,152,930 | $21,871 |
| GOLDMAN SACHS GROUP INC | 1,077,573 | $20,442 |
| Affinity Asset Advisors, LLC | 967,620 | $18,356 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 965,892 | $18,323 |
| Longaeva Partners L.P. | 927,729 | $17,599 |
| Woodline Partners LP | 925,444 | $17,556 |
| NORTHERN TRUST CORP | 805,682 | $15,284 |
| Nuveen, LLC | 784,409 | $14,880 |
| BANK OF AMERICA CORP /DE/ | 736,558 | $13,973 |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 735,174 | $13,946 |
| Handelsbanken Fonder AB | 547,000 | $10 |
| Rhenman & Partners Asset Management AB | 537,500 | $10,196 |
| Candriam S.C.A. | 534,259 | $10,135 |
| Logos Global Management LP | 500,000 | $9,485 |
| Elmind Capital, LP | 460,000 | $8,726 |
| DIMENSIONAL FUND ADVISORS LP | 430,986 | $8,176 |
| UBS Group AG | 423,425 | $8,032 |
| Invesco Ltd. | 343,830 | $6,522 |
| ArrowMark Colorado Holdings LLC | 314,762 | $5,971 |
| BESSEMER GROUP INC | 306,003 | $6 |
| Integral Health Asset Management, LLC | 300,000 | $5,691 |
| Bank of New York Mellon Corp | 288,143 | $5,466 |
| WELLINGTON MANAGEMENT GROUP LLP | 275,178 | $5,220 |
| KENNEDY CAPITAL MANAGEMENT LLC | 261,204 | $4,955 |
| BARCLAYS PLC | 256,684 | $4,869 |
| TD Asset Management Inc | 237,200 | $4,500 |
| Ensign Peak Advisors, Inc | 230,828 | $4,379 |
| WestHill Financial Advisors, Inc. | 228,333 | $4,331 |
| MILLENNIUM MANAGEMENT LLC | 179,759 | $3,410 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 172,364 | $3,277 |
| CITIGROUP INC | 171,102 | $3,246 |
| UBS ASSET MANAGEMENT AMERICAS INC | 168,843 | $3,203 |
| T. Rowe Price Investment Management, Inc. | 154,633 | $3 |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 154,459 | $2,930 |
| Swiss National Bank | 150,000 | $2,846 |
| BNP PARIBAS ARBITRAGE, SA | 132,094 | $2,506 |
| AMERIPRISE FINANCIAL INC | 124,749 | $2,366 |
| SPHERA FUNDS MANAGEMENT LTD. | 124,000 | $2,352 |
| ALGERT GLOBAL LLC | 119,657 | $2 |
| JANE STREET GROUP, LLC | 119,404 | $2,265 |
| Burkehill Global Management, LP | 118,972 | $2,257 |
| RHUMBLINE ADVISERS | 118,598 | $2,250 |
| BALYASNY ASSET MANAGEMENT L.P. | 118,481 | $2,248 |
| WELLS FARGO & COMPANY/MN | 117,854 | $2,236 |
| Hudson Bay Capital Management LP | 110,000 | $2,087 |
| Boxer Capital Management, LLC | 100,000 | $1,897 |
| ALLIANCEBERNSTEIN L.P. | 98,190 | $1,863 |
| Jasper Ridge Partners, L.P. | 95,711 | $1,816 |
| Rafferty Asset Management, LLC | 90,515 | $1,717 |
| Susquehanna Portfolio Strategies, LLC | 86,423 | $1,639 |
| Vienna Powszechne Towarzystwo Emerytalne S.A. Vienna Insurance Group | 85,000 | $1,612 |
| Legal & General Group Plc | 84,989 | $1,612 |
| FLAX POND CAPITAL, LLC | 80,200 | $1,521 |
| Jump Financial, LLC | 80,037 | $1,518 |
| EDMOND DE ROTHSCHILD HOLDING S.A. | 80,000 | $1,518 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 79,325 | $1,505 |
| NEOS Investment Management LLC | 77,775 | $1,475 |
| Trexquant Investment LP | 77,359 | $1,468 |
| TEMA ETFS LLC | 76,625 | $1,454 |
| Walleye Capital LLC | 74,869 | $1,420 |
| ADAR1 Capital Management, LLC | 72,070 | $1,367 |
| Verition Fund Management LLC | 68,754 | $1,304 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 68,019 | $1,290 |
| IQ EQ FUND MANAGEMENT (IRELAND) Ltd | 65,545 | $1,243 |
| Russell Investments Group, Ltd. | 63,482 | $1,204 |
| Polymer Capital Management (HK) LTD | 58,898 | $1,117 |
| MetLife Investment Management, LLC | 55,345 | $1,050 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 50,553 | $959 |
| Cinctive Capital Management LP | 47,707 | $905 |
| JPMORGAN CHASE & CO | 47,288 | $897 |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 43,743 | $830 |
| AMERICAN CENTURY COMPANIES INC | 42,878 | $813 |
| JANUS HENDERSON GROUP PLC | 39,400 | $748 |
| Voya Investment Management LLC | 36,959 | $701 |
| 82 other institutions | 887,337 | $16,055 |