| RA CAPITAL MANAGEMENT, L.P. | 10,860,977 | $126,530 |
| ORBIMED ADVISORS LLC | 8,288,510 | $96,561 |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 7,503,812 | $87,419 |
| Rubric Capital Management LP | 6,200,000 | $72,230 |
| BlackRock, Inc. | 5,085,317 | $59,244 |
| SR ONE CAPITAL MANAGEMENT, LP | 4,012,903 | $46,750 |
| abrdn plc | 3,556,049 | $41,428 |
| VANGUARD GROUP INC | 3,509,174 | $40,882 |
| STATE STREET CORP | 3,223,581 | $37,555 |
| MILLENNIUM MANAGEMENT LLC | 3,168,406 | $36,912 |
| FRANKLIN RESOURCES INC | 2,543,097 | $29,627 |
| UBS Group AG | 2,210,866 | $25,757 |
| Tyro Capital Management LLC | 1,994,852 | $23,240 |
| CITADEL ADVISORS LLC | 1,954,472 | $22,770 |
| Casdin Capital, LLC | 1,600,000 | $18,640 |
| GEODE CAPITAL MANAGEMENT, LLC | 1,552,870 | $18,094 |
| Southpoint Capital Advisors LP | 1,500,000 | $17,475 |
| Janney Montgomery Scott LLC | 1,287,832 | $15 |
| BAMCO INC /NY/ | 1,268,532 | $14,778 |
| GOLDMAN SACHS GROUP INC | 812,036 | $9,460 |
| FIL Ltd | 810,073 | $9,437 |
| LEVIN CAPITAL STRATEGIES, L.P. | 747,506 | $8,708 |
| Nextech Invest, Ltd. | 660,703 | $7,697 |
| BANK OF MONTREAL /CAN/ | 643,407 | $7,496 |
| CenterBook Partners LP | 568,361 | $6,621 |
| RAYMOND JAMES FINANCIAL INC | 566,056 | $6,595 |
| GENERAL AMERICAN INVESTORS CO INC | 559,959 | $6,524 |
| Third Point LLC | 556,237 | $6,480 |
| MORGAN STANLEY | 552,364 | $6,435 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 550,932 | $6,418 |
| NORTHERN TRUST CORP | 521,009 | $6,070 |
| BANK OF AMERICA CORP /DE/ | 482,084 | $5,616 |
| AMERICAN CENTURY COMPANIES INC | 455,766 | $5,310 |
| Alyeska Investment Group, L.P. | 418,883 | $4,880 |
| JPMORGAN CHASE & CO | 417,090 | $4,859 |
| FMR LLC | 398,959 | $4,648 |
| Lisanti Capital Growth, LLC | 396,509 | $4,619 |
| ADAR1 Capital Management, LLC | 369,569 | $4,305 |
| Empire Life Investments Inc. | 352,602 | $4,108 |
| INVESTMENT MANAGEMENT ASSOCIATES INC /ADV | 311,503 | $3,629 |
| UBS ASSET MANAGEMENT AMERICAS INC | 304,445 | $3,547 |
| Creek Drive Management Group LLC | 295,863 | $3,447 |
| Eversept Partners, LP | 251,593 | $2,931 |
| Steward Partners Investment Advisory, LLC | 216,296 | $2,520 |
| ROYCE & ASSOCIATES LP | 207,051 | $2,412 |
| FAS Wealth Partners, Inc. | 202,407 | $2,358 |
| BOOTHBAY FUND MANAGEMENT, LLC | 201,474 | $2,347 |
| BARCLAYS PLC | 196,387 | $2,288 |
| DAFNA Capital Management LLC | 190,065 | $2,214 |
| DIMENSIONAL FUND ADVISORS LP | 176,122 | $2,052 |
| WEXFORD CAPITAL LP | 165,313 | $1,926 |
| Bank of New York Mellon Corp | 163,006 | $1,899 |
| Quinn Opportunity Partners LLC | 155,000 | $1,806 |
| Woodline Partners LP | 150,936 | $1,758 |
| Trexquant Investment LP | 150,100 | $1,749 |
| Nuveen, LLC | 149,597 | $1,743 |
| Knights of Columbus Asset Advisors LLC | 130,729 | $1,523 |
| Rafferty Asset Management, LLC | 115,564 | $1,346 |
| PRINCIPAL FINANCIAL GROUP INC | 112,766 | $1,314 |
| Swiss National Bank | 107,200 | $1,249 |
| SIT INVESTMENT ASSOCIATES INC | 92,875 | $1 |
| Cambridge Investment Research Advisors, Inc. | 87,161 | $1 |
| VALLEY FORGE INVESTMENT CONSULTANTS INC ADV | 83,225 | $970 |
| ALPS ADVISORS INC | 81,168 | $946 |
| MARSHALL WACE, LLP | 79,214 | $923 |
| SG Americas Securities, LLC | 76,203 | $1 |
| AssuredPartners Investment Advisors, LLC | 75,779 | $883 |
| SEI INVESTMENTS CO | 74,807 | $872 |
| WELLS FARGO & COMPANY/MN | 74,256 | $865 |
| RHUMBLINE ADVISERS | 73,293 | $854 |
| HRT FINANCIAL LP | 68,645 | $1 |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 65,746 | $567 |
| ALLIANCEBERNSTEIN L.P. | 60,120 | $700 |
| Legal & General Group Plc | 58,368 | $680 |
| Matisse Capital | 55,561 | $647 |
| AMERICAN ASSETS INC | 55,000 | $641 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 54,098 | $630 |
| Coastal Bridge Advisors, LLC | 53,830 | $627 |
| Quantinno Capital Management LP | 53,113 | $619 |
| Permanent Capital Management, LP | 52,306 | $609 |
| SCHULHOFF & CO INC | 51,150 | $596 |
| DEUTSCHE BANK AG\ | 48,727 | $568 |
| PROFUND ADVISORS LLC | 42,808 | $499 |
| FOX RUN MANAGEMENT, L.L.C. | 38,587 | $450 |
| Invesco Ltd. | 37,230 | $434 |
| XTX Topco Ltd | 37,201 | $433 |
| Aquatic Capital Management LLC | 36,037 | $420 |
| MetLife Investment Management, LLC | 34,338 | $400 |
| Voya Investment Management LLC | 34,128 | $398 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 34,100 | $397 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 33,788 | $0 |
| DIKER MANAGEMENT LLC | 33,508 | $390 |
| AlphaQuest LLC | 32,970 | $384 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 32,058 | $373 |
| Private Advisor Group, LLC | 31,460 | $367 |
| Cresset Asset Management, LLC | 30,152 | $351 |
| SECTORAL ASSET MANAGEMENT INC | 29,803 | $347 |
| CANADA PENSION PLAN INVESTMENT BOARD | 29,600 | $345 |
| Freestone Grove Partners LP | 28,003 | $326 |
| HighTower Advisors, LLC | 26,529 | $309 |
| 86 other institutions | 674,844 | $7,367 |