DENALI THERAPEUTICS INC

Ticker: DNLI CUSIP: 24823R105 Class: Common Stock

Note: Option positions (PUT/CALL) are excluded.

New Positions (41)

Increased Positions (83)

Lynx1 Capital Management LP
Value ($000) $28,707 (+655.5%) Shares 1,738,750 (+564.4%)
Casdin Capital, LLC
Value ($000) $30,378 (+135.1%) Shares 1,840,000 (+106.7%)
Palo Alto Investors LP
Value ($000) $10,587 (+78.7%) Shares 641,239 (+57.2%)
DAFNA Capital Management LLC
Value ($000) $5,258 (+114.9%) Shares 318,500 (+89.0%)
Siren, L.L.C.
Value ($000) $23,056 (+93.3%) Shares 1,396,513 (+70.0%)
MASTERS CAPITAL MANAGEMENT LLC
Value ($000) $16,510 (+51.6%) Shares 1,000,000 (+33.3%)
Temasek Holdings (Private) Ltd
Value ($000) $115,784 (+48.9%) Shares 7,012,974 (+30.9%)
Candriam S.C.A.
Value ($000) $19,258 (+59.1%) Shares 1,166,379 (+39.9%)
abrdn plc
Value ($000) $33,564 (+107.6%) Shares 2,032,967 (+82.6%)
Virtus Investment Advisers, LLC
Value ($000) $244 (+120.7%) Shares 14,795 (+94.1%)
BAILLIE GIFFORD & CO
Value ($000) $203,253 (+20.8%) Shares 12,310,889 (+6.2%)
Pictet Asset Management Holding SA
Value ($000) $21,981 (+203.3%) Shares 1,329,108 (+166.3%)
PROFUND ADVISORS LLC
Value ($000) $1,183 (+102.8%) Shares 71,634 (+78.4%)
Clarius Group, LLC
Value ($000) $6,092 (+16.6%) Shares 368,995 (+2.6%)
Fisher Asset Management, LLC
Value ($000) $42,751 (+80.5%) Shares 2,589,403 (+58.7%)
GOLDMAN SACHS GROUP INC
Value ($000) $63,329 (+101.6%) Shares 3,835,803 (+77.3%)
Hudson Bay Capital Management LP
Value ($000) $7,430 (+67.8%) Shares 450,000 (+47.5%)
Qube Research & Technologies Ltd
Value ($000) $9,746 (+194.4%) Shares 590,314 (+158.9%)
NORGES BANK
Value ($000) $84,525 (+53.1%) Shares 5,119,622 (+29.7%)
SEGALL BRYANT & HAMILL, LLC
Value ($000) $8,866 (+19.0%) Shares 537,000 (+4.7%)

Decreased Positions (66)

STEMPOINT CAPITAL LP
Value ($000) $6,919 (-72.5%) Shares 419,058 (-75.8%)
Crestline Management, LP
Value ($000) $46,405 (-6.3%) Shares 2,810,732 (-17.6%)
TT International Asset Management LTD
Value ($000) $0 (-100.0%) Shares 27,000 (-58.5%)
Trexquant Investment LP
Value ($000) $3,461 (-44.6%) Shares 209,609 (-51.3%)
T. Rowe Price Investment Management, Inc.
Value ($000) $21 (-74.9%) Shares 1,245,994 (-77.9%)
Point72 Asset Management, L.P.
Value ($000) $28,067 (-23.3%) Shares 1,700,000 (-32.5%)
AlphaQuest LLC
Value ($000) $708 (-34.4%) Shares 42,909 (-42.3%)
Jump Financial, LLC
Value ($000) $670 (-72.3%) Shares 40,608 (-75.6%)
VOLORIDGE INVESTMENT MANAGEMENT, LLC
Value ($000) $9,765 (-28.2%) Shares 591,461 (-36.8%)
Savvy Advisors, Inc.
Value ($000) $644 (-42.4%) Shares 39,030 (-49.4%)
MILLENNIUM MANAGEMENT LLC
Value ($000) $6,105 (-67.8%) Shares 369,767 (-71.7%)
IRONWOOD INVESTMENT MANAGEMENT LLC
Value ($000) $841 (+9.7%) Shares 50,933 (-3.5%)
Capital Research Global Investors
Value ($000) $61,570 (-10.9%) Shares 3,729,244 (-21.7%)
State of New Jersey Common Pension Fund D
Value ($000) $783 (-61.4%) Shares 47,410 (-66.1%)
UBS ASSET MANAGEMENT AMERICAS INC
Value ($000) $82,281 (+3.7%) Shares 4,983,726 (-8.8%)
Graham Capital Management, L.P.
Value ($000) $299 (-47.6%) Shares 18,121 (-53.9%)
BNP PARIBAS ARBITRAGE, SA
Value ($000) $256 (-93.3%) Shares 15,497 (-94.1%)
ROYAL BANK OF CANADA
Value ($000) $187 (-96.5%) Shares 11,335 (-97.0%)
MORGAN STANLEY
Value ($000) $20,140 (-17.9%) Shares 1,219,854 (-27.8%)
GUGGENHEIM CAPITAL LLC
Value ($000) $206 (-71.4%) Shares 12,468 (-74.8%)

Exited Positions (36)