| SUVRETTA CAPITAL MANAGEMENT, LLC | 11,964,000 | $347,435 |
| Frazier Life Sciences Management, L.P. | 9,874,511 | $286,756 |
| BlackRock, Inc. | 9,099,579 | $264,252 |
| Rubric Capital Management LP | 8,271,577 | $240,207 |
| VANGUARD GROUP INC | 7,253,936 | $210,654 |
| JENNISON ASSOCIATES LLC | 6,758,006 | $196,252 |
| Polar Capital Holdings Plc | 5,556,169 | $161,351 |
| STATE STREET CORP | 5,488,301 | $159,380 |
| GILDER GAGNON HOWE & CO LLC | 4,453,856 | $129,340 |
| MORGAN STANLEY | 4,340,239 | $126,041 |
| UBS Group AG | 3,243,432 | $94,189 |
| GEODE CAPITAL MANAGEMENT, LLC | 2,753,307 | $79,967 |
| D. E. Shaw & Co., Inc. | 2,683,087 | $77,917 |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 2,562,445 | $74,413 |
| Ensign Peak Advisors, Inc | 1,902,390 | $55,245 |
| FRANKLIN RESOURCES INC | 1,900,084 | $55,178 |
| JANUS HENDERSON GROUP PLC | 1,830,061 | $53,154 |
| BANK OF AMERICA CORP /DE/ | 1,673,454 | $48,597 |
| GOLDMAN SACHS GROUP INC | 1,576,413 | $45,779 |
| AMERICAN CENTURY COMPANIES INC | 1,467,176 | $42,607 |
| Nuveen, LLC | 1,382,160 | $40,138 |
| Pivotal bioVenture Partners Investment Advisor LLC | 1,366,624 | $39,687 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,166,348 | $34 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,014,826 | $29,471 |
| GW&K Investment Management, LLC | 1,008,580 | $29 |
| NORTHERN TRUST CORP | 955,235 | $27,740 |
| DEUTSCHE BANK AG\ | 930,202 | $27,013 |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 914,020 | $26,543 |
| Perpetual Ltd | 910,630 | $26,445 |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 900,000 | $26,136 |
| FEDERATED HERMES, INC. | 891,767 | $25,897 |
| OBERWEIS ASSET MANAGEMENT INC/ | 808,400 | $23,476 |
| Candriam S.C.A. | 803,138 | $23,324 |
| BNP PARIBAS ARBITRAGE, SA | 699,803 | $20,322 |
| Qube Research & Technologies Ltd | 661,415 | $19,207 |
| Nearwater Capital Markets, Ltd | 615,000 | $17,860 |
| abrdn plc | 586,397 | $17,029 |
| FISHMAN JAY A LTD/MI | 564,650 | $16,397 |
| MPM BioImpact LLC | 531,200 | $15,426 |
| BAMCO INC /NY/ | 504,700 | $14,656 |
| Cormorant Asset Management, LP | 500,000 | $14,520 |
| Capitolis Liquid Global Markets LLC | 500,000 | $14,520 |
| AQR CAPITAL MANAGEMENT LLC | 499,418 | $14,503 |
| Squarepoint Ops LLC | 455,876 | $13,239 |
| MARSHALL WACE, LLP | 454,233 | $13,191 |
| Eversept Partners, LP | 434,634 | $12,622 |
| Jump Financial, LLC | 430,902 | $12,513 |
| Point72 Asset Management, L.P. | 425,152 | $12,346 |
| FIRST TRUST ADVISORS LP | 404,654 | $11,751 |
| TWO SIGMA INVESTMENTS, LP | 400,862 | $11,641 |
| BARCLAYS PLC | 331,578 | $9,629 |
| JUPITER ASSET MANAGEMENT LTD | 326,538 | $9,483 |
| CASTLEARK MANAGEMENT LLC | 309,430 | $8,986 |
| Invesco Ltd. | 307,382 | $8,926 |
| Privium Fund Management B.V. | 305,972 | $8,885 |
| Bank of New York Mellon Corp | 304,428 | $8,841 |
| WELLS FARGO & COMPANY/MN | 284,243 | $8,254 |
| RENAISSANCE TECHNOLOGIES LLC | 273,999 | $7,957 |
| MYDA Advisors LLC | 265,000 | $7,696 |
| MILLENNIUM MANAGEMENT LLC | 236,770 | $6,876 |
| PRUDENTIAL FINANCIAL INC | 234,915 | $6,822 |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 234,071 | $6,797 |
| UBS ASSET MANAGEMENT AMERICAS INC | 231,734 | $6,730 |
| STEMPOINT CAPITAL LP | 224,740 | $6,526 |
| JANE STREET GROUP, LLC | 221,426 | $6,430 |
| EAM Investors, LLC | 213,863 | $6,211 |
| Swiss National Bank | 212,800 | $6,180 |
| Patient Square Capital LP | 210,000 | $6,098 |
| FMR LLC | 205,424 | $5,966 |
| NORDEA INVESTMENT MANAGEMENT AB | 201,638 | $5,850 |
| Woodline Partners LP | 195,033 | $5,664 |
| Hillsdale Investment Management Inc. | 179,420 | $5,210 |
| Voleon Capital Management LP | 176,600 | $5,128 |
| NORGES BANK | 174,820 | $5,077 |
| Rafferty Asset Management, LLC | 172,066 | $4,997 |
| Walleye Capital LLC | 168,604 | $4,896 |
| RHUMBLINE ADVISERS | 161,402 | $4,687 |
| TWO SIGMA ADVISERS, LP | 156,100 | $4,533 |
| CITADEL ADVISORS LLC | 155,158 | $4,506 |
| PDT Partners, LLC | 155,075 | $4,503 |
| RAYMOND JAMES FINANCIAL INC | 144,949 | $4,209 |
| ESSEX INVESTMENT MANAGEMENT CO LLC | 141,271 | $4,103 |
| DekaBank Deutsche Girozentrale | 140,000 | $1 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 125,979 | $3,590 |
| ALLIANCEBERNSTEIN L.P. | 116,360 | $3,379 |
| KORNITZER CAPITAL MANAGEMENT INC /KS | 113,385 | $3,293 |
| LPL Financial LLC | 111,874 | $3,249 |
| JPMORGAN CHASE & CO | 106,488 | $3,092 |
| TUDOR INVESTMENT CORP ET AL | 106,134 | $3,082 |
| SEI INVESTMENTS CO | 104,286 | $3,028 |
| Legal & General Group Plc | 104,013 | $3,021 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 102,439 | $2,975 |
| STATE OF WISCONSIN INVESTMENT BOARD | 99,247 | $2,882 |
| AMERIPRISE FINANCIAL INC | 98,826 | $2,870 |
| TD Asset Management Inc | 97,200 | $2,823 |
| LAZARD ASSET MANAGEMENT LLC | 93,354 | $2,711 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 88,480 | $2,560 |
| Pictet Asset Management Holding SA | 87,687 | $2,511 |
| Engineers Gate Manager LP | 86,605 | $2,515 |
| ALGERT GLOBAL LLC | 86,260 | $3 |
| 176 other institutions | 3,199,148 | $82,457 |