| Flagship Pioneering, LLC | 12,674,120 | $68,440 |
| FMR LLC | 5,396,814 | $29,143 |
| BVF INC/IL | 5,302,000 | $28,631 |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 3,649,211 | $19,706 |
| RAYMOND JAMES FINANCIAL INC | 2,505,821 | $13,531 |
| BlackRock, Inc. | 2,349,870 | $12,689 |
| VANGUARD GROUP INC | 1,928,992 | $10,417 |
| Euclidean Capital LLC | 1,573,761 | $8,498 |
| GEODE CAPITAL MANAGEMENT, LLC | 795,040 | $4,294 |
| Siren, L.L.C. | 720,720 | $3,892 |
| STATE STREET CORP | 618,666 | $3,341 |
| AMERIPRISE FINANCIAL INC | 607,670 | $3,281 |
| RENAISSANCE TECHNOLOGIES LLC | 297,736 | $1,608 |
| Birchview Capital, LP | 281,730 | $1,521 |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 269,186 | $1,454 |
| NORTHERN TRUST CORP | 262,430 | $1,417 |
| MILLENNIUM MANAGEMENT LLC | 208,565 | $1,126 |
| CITADEL ADVISORS LLC | 182,276 | $984 |
| Squarepoint Ops LLC | 141,580 | $765 |
| JANE STREET GROUP, LLC | 132,501 | $716 |
| DAFNA Capital Management LLC | 126,859 | $685 |
| Sio Capital Management, LLC | 122,889 | $664 |
| MORGAN STANLEY | 121,727 | $657 |
| GOLDMAN SACHS GROUP INC | 118,701 | $641 |
| SCS Capital Management LLC | 106,980 | $578 |
| PANAGORA ASSET MANAGEMENT INC | 89,295 | $482 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 82,363 | $445 |
| Walleye Capital LLC | 81,348 | $439 |
| Bank of New York Mellon Corp | 78,898 | $426 |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 74,600 | $403 |
| BANK OF AMERICA CORP /DE/ | 73,859 | $399 |
| BARCLAYS PLC | 63,190 | $341 |
| Point72 Asset Management, L.P. | 61,968 | $335 |
| Qube Research & Technologies Ltd | 53,257 | $288 |
| STATE OF WISCONSIN INVESTMENT BOARD | 53,144 | $287 |
| Nuveen, LLC | 50,133 | $271 |
| Persistent Asset Partners Ltd | 47,108 | $254 |
| RHUMBLINE ADVISERS | 40,117 | $217 |
| WELLS FARGO & COMPANY/MN | 38,755 | $209 |
| DIADEMA PARTNERS LP | 30,630 | $165 |
| MARSHALL WACE, LLP | 28,893 | $156 |
| DEUTSCHE BANK AG\ | 27,421 | $148 |
| ALLIANCEBERNSTEIN L.P. | 26,660 | $144 |
| UBS Group AG | 24,505 | $132 |
| Jump Financial, LLC | 24,129 | $130 |
| Woodline Partners LP | 21,523 | $116 |
| MetLife Investment Management, LLC | 19,143 | $103 |
| JPMORGAN CHASE & CO | 17,219 | $93 |
| TWO SIGMA INVESTMENTS, LP | 16,600 | $90 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 16,408 | $0 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 15,862 | $86 |
| XTX Topco Ltd | 15,662 | $85 |
| INTECH INVESTMENT MANAGEMENT LLC | 14,576 | $79 |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 14,269 | $77 |
| ALGERT GLOBAL LLC | 13,928 | $0 |
| AQR CAPITAL MANAGEMENT LLC | 13,550 | $73 |
| CANADA PENSION PLAN INVESTMENT BOARD | 12,800 | $69 |
| Police & Firemen's Retirement System of New Jersey | 11,326 | $61 |
| Fiduciary Trust Co | 10,879 | $59 |
| Invesco Ltd. | 10,785 | $58 |
| Brevan Howard Capital Management LP | 10,486 | $57 |
| TWO SIGMA ADVISERS, LP | 10,400 | $56 |
| China Universal Asset Management Co., Ltd. | 9,215 | $50 |
| STRS OHIO | 8,600 | $46 |
| BNP PARIBAS ARBITRAGE, SA | 8,273 | $45 |
| ACADIAN ASSET MANAGEMENT LLC | 7,726 | $0 |
| Evelyn Partners Asset Management Ltd | 7,100 | $38 |
| Russell Investments Group, Ltd. | 5,938 | $32 |
| NISA INVESTMENT ADVISORS, LLC | 5,238 | $28 |
| Brummer Multi-Strategy AB | 4,708 | $25 |
| Legal & General Group Plc | 3,378 | $18 |
| Ameritas Investment Partners, Inc. | 3,343 | $18 |
| Mirae Asset Global Investments Co., Ltd. | 2,748 | $15 |
| CITIGROUP INC | 2,330 | $13 |
| Tower Research Capital LLC (TRC) | 2,073 | $11 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 2,048 | $11 |
| NEW YORK STATE COMMON RETIREMENT FUND | 1,871 | $10 |
| CWM, LLC | 1,349 | $0 |
| GF FUND MANAGEMENT CO. LTD. | 1,111 | $6 |
| AMALGAMATED BANK | 1,046 | $0 |
| OSAIC HOLDINGS, INC. | 1,029 | $6 |
| ROYAL BANK OF CANADA | 1,004 | $6 |
| Sunbelt Securities, Inc. | 1,000 | $5 |
| Sterling Capital Management LLC | 847 | $5 |
| UBS ASSET MANAGEMENT AMERICAS INC | 374 | $2 |
| GAMMA Investing LLC | 364 | $2 |
| Optiver Holding B.V. | 310 | $2 |
| NATIONAL BANK OF CANADA /FI/ | 200 | $1 |
| TFC Financial Management, Inc. | 123 | $1 |
| SBI Securities Co., Ltd. | 100 | $1 |
| PNC Financial Services Group, Inc. | 84 | $0 |
| EverSource Wealth Advisors, LLC | 75 | $0 |
| True Wealth Design, LLC | 5 | $0 |