| AyurMaya Capital Management Company, LP | 15,139,706 | $147,764 |
| Foresite Capital Management V, LLC | 5,779,348 | $56,406 |
| Samsara BioCapital, LLC | 5,756,984 | $56,188 |
| venBio Partners LLC | 4,619,803 | $45,089 |
| BlackRock, Inc. | 4,566,502 | $44,569 |
| Foresite Capital Management VI LLC | 4,247,670 | $41,457 |
| VANGUARD GROUP INC | 4,103,290 | $40,048 |
| Cormorant Asset Management, LP | 3,635,596 | $35,483 |
| Saturn V Capital Management LP | 3,135,953 | $30,607 |
| Nextech Invest, Ltd. | 2,915,998 | $28,460 |
| Octagon Capital Advisors LP | 2,530,700 | $24,700 |
| MPM BioImpact LLC | 2,401,992 | $23,443 |
| SR ONE CAPITAL MANAGEMENT, LP | 1,959,896 | $19,129 |
| BAKER BROS. ADVISORS LP | 1,562,500 | $15,250 |
| GEODE CAPITAL MANAGEMENT, LLC | 1,487,626 | $14,523 |
| STATE STREET CORP | 1,259,446 | $12,292 |
| MILLENNIUM MANAGEMENT LLC | 1,151,118 | $11,235 |
| ORBIMED ADVISORS LLC | 1,102,730 | $10,763 |
| Trium Capital LLP | 893,107 | $8,717 |
| Yu Fan | 789,618 | $7,707 |
| Omega Fund Management, LLC | 653,223 | $6,375 |
| Opaleye Management Inc. | 535,000 | $5,222 |
| MORGAN STANLEY | 506,529 | $4,944 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 504,075 | $4,920 |
| Siren, L.L.C. | 500,000 | $4,880 |
| TOWERVIEW LLC | 495,000 | $4,831 |
| GOLDMAN SACHS GROUP INC | 427,072 | $4,168 |
| Invesco Ltd. | 421,819 | $4,117 |
| NORTHERN TRUST CORP | 418,248 | $4,082 |
| MARSHALL WACE, LLP | 372,901 | $3,640 |
| JPMORGAN CHASE & CO | 356,337 | $3,478 |
| TWO SIGMA INVESTMENTS, LP | 298,219 | $2,911 |
| Exome Asset Management LLC | 292,250 | $2,852 |
| D. E. Shaw & Co., Inc. | 231,747 | $2,262 |
| STIFEL FINANCIAL CORP | 209,729 | $2,047 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 208,133 | $2,031 |
| JANE STREET GROUP, LLC | 173,833 | $1,697 |
| Susquehanna Portfolio Strategies, LLC | 172,779 | $1,686 |
| Nuveen, LLC | 169,506 | $1,654 |
| WELLINGTON MANAGEMENT GROUP LLP | 169,093 | $1,650 |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 163,084 | $760 |
| Bank of New York Mellon Corp | 160,138 | $1,563 |
| Mariner, LLC | 145,045 | $1,416 |
| BANK OF AMERICA CORP /DE/ | 138,341 | $1,350 |
| AQR CAPITAL MANAGEMENT LLC | 137,792 | $1,345 |
| Quantinno Capital Management LP | 135,446 | $1,322 |
| WELLS FARGO & COMPANY/MN | 129,448 | $1,263 |
| BARCLAYS PLC | 122,210 | $1,193 |
| CITADEL ADVISORS LLC | 119,311 | $1,164 |
| UBS Group AG | 113,997 | $1,113 |
| RENAISSANCE TECHNOLOGIES LLC | 108,200 | $1,056 |
| PRELUDE CAPITAL MANAGEMENT, LLC | 87,832 | $857 |
| Verition Fund Management LLC | 80,062 | $781 |
| ALLIANCEBERNSTEIN L.P. | 76,594 | $748 |
| RHUMBLINE ADVISERS | 69,236 | $676 |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 56,728 | $554 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 50,422 | $0 |
| Virtu Financial LLC | 50,283 | $0 |
| BNP PARIBAS ARBITRAGE, SA | 46,884 | $458 |
| PSP Research LLC | 43,769 | $427 |
| DEUTSCHE BANK AG\ | 41,112 | $401 |
| LMR Partners LLP | 40,000 | $390 |
| Creative Planning | 38,110 | $372 |
| TWO SIGMA ADVISERS, LP | 38,074 | $372 |
| FOX RUN MANAGEMENT, L.L.C. | 37,707 | $368 |
| Brevan Howard Capital Management LP | 34,917 | $341 |
| MetLife Investment Management, LLC | 32,479 | $317 |
| Grange Capital, LLC | 32,000 | $312 |
| GSA CAPITAL PARTNERS LLP | 30,913 | $0 |
| INTECH INVESTMENT MANAGEMENT LLC | 29,303 | $286 |
| Inscription Capital, LLC | 26,667 | $260 |
| Dynamic Technology Lab Private Ltd | 26,567 | $259 |
| AXQ CAPITAL, LP | 26,417 | $258 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 26,240 | $256 |
| XTX Topco Ltd | 24,955 | $244 |
| BALYASNY ASSET MANAGEMENT L.P. | 24,769 | $242 |
| FMR LLC | 23,987 | $234 |
| Virtus Investment Advisers, LLC | 23,153 | $226 |
| Schonfeld Strategic Advisors LLC | 23,028 | $225 |
| BANK OF NOVA SCOTIA | 20,900 | $204 |
| DIMENSIONAL FUND ADVISORS LP | 20,516 | $200 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 17,661 | $172 |
| IEQ CAPITAL, LLC | 17,421 | $170 |
| China Universal Asset Management Co., Ltd. | 15,840 | $155 |
| Police & Firemen's Retirement System of New Jersey | 15,340 | $150 |
| Russell Investments Group, Ltd. | 15,029 | $147 |
| MERCER GLOBAL ADVISORS INC /ADV | 14,908 | $146 |
| ProShare Advisors LLC | 14,627 | $143 |
| PDT Partners, LLC | 14,562 | $142 |
| Banco BTG Pactual S.A. | 14,302 | $140 |
| CITIGROUP INC | 14,070 | $137 |
| NEW YORK STATE COMMON RETIREMENT FUND | 11,767 | $115 |
| ExodusPoint Capital Management, LP | 11,197 | $109 |
| Kera Capital Partners, Inc. | 11,003 | $270 |
| CWM, LLC | 10,431 | $0 |
| AMERICAN CENTURY COMPANIES INC | 10,322 | $101 |
| Birchview Capital, LP | 10,000 | $98 |
| Legal & General Group Plc | 4,954 | $48 |
| Ameritas Investment Partners, Inc. | 4,827 | $47 |
| Mirae Asset Global Investments Co., Ltd. | 4,724 | $46 |
| 33 other institutions | 27,690 | $249 |