| NEA Management Company, LLC | 18,093,034 | $56,088 |
| BlackRock, Inc. | 17,056,878 | $52,876 |
| Octagon Capital Advisors LP | 13,915,371 | $43,138 |
| VANGUARD GROUP INC | 12,873,209 | $39,907 |
| STATE STREET CORP | 9,310,969 | $28,864 |
| ARCH Venture Management, LLC | 8,055,916 | $24,973 |
| Samsara BioCapital, LLC | 7,222,559 | $22,390 |
| Siren, L.L.C. | 5,208,968 | $16,148 |
| 683 Capital Management, LLC | 5,190,800 | $16,091 |
| HHLR ADVISORS, LTD. | 4,974,041 | $15,420 |
| GEODE CAPITAL MANAGEMENT, LLC | 4,872,714 | $15,109 |
| Palo Alto Investors LP | 4,471,592 | $13,862 |
| ACADIAN ASSET MANAGEMENT LLC | 4,416,903 | $14 |
| FMR LLC | 4,237,590 | $13,137 |
| Corient Private Wealth LLC | 3,845,885 | $11,922 |
| MILLENNIUM MANAGEMENT LLC | 3,584,288 | $11,111 |
| TWO SIGMA INVESTMENTS, LP | 3,397,110 | $10,531 |
| Rock Springs Capital Management LP | 3,266,960 | $10,128 |
| PERCEPTIVE ADVISORS LLC | 3,139,669 | $9,733 |
| Opaleye Management Inc. | 2,720,000 | $8,432 |
| TWO SIGMA ADVISERS, LP | 2,596,900 | $8,050 |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 2,178,033 | $6,752 |
| SILVERARC CAPITAL MANAGEMENT, LLC | 2,135,722 | $6,621 |
| BANK OF AMERICA CORP /DE/ | 1,906,669 | $5,911 |
| GOLDMAN SACHS GROUP INC | 1,792,114 | $5,556 |
| UBS Group AG | 1,771,381 | $5,491 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,685,778 | $5,226 |
| MB Generational Wealth, LLC | 1,605,449 | $4,977 |
| BALYASNY ASSET MANAGEMENT L.P. | 1,516,691 | $4,702 |
| NORTHERN TRUST CORP | 1,416,540 | $4,391 |
| DEUTSCHE BANK AG\ | 1,284,335 | $3,981 |
| AQR CAPITAL MANAGEMENT LLC | 1,119,240 | $3,470 |
| Walleye Capital LLC | 1,077,032 | $3,339 |
| Monashee Investment Management LLC | 1,000,000 | $3,100 |
| Integral Health Asset Management, LLC | 1,000,000 | $3,100 |
| HRT FINANCIAL LP | 956,879 | $3 |
| MORGAN STANLEY | 918,888 | $2,849 |
| Alyeska Investment Group, L.P. | 909,087 | $2,818 |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 750,308 | $2,326 |
| CITADEL ADVISORS LLC | 704,787 | $2,185 |
| RENAISSANCE TECHNOLOGIES LLC | 658,888 | $2,043 |
| Hennion & Walsh Asset Management, Inc. | 652,977 | $2,024 |
| WELLINGTON MANAGEMENT GROUP LLP | 601,323 | $1,864 |
| BARCLAYS PLC | 576,533 | $1,787 |
| PLATINUM INVESTMENT MANAGEMENT LTD | 561,951 | $1,742 |
| Qube Research & Technologies Ltd | 540,567 | $1,676 |
| Connor, Clark & Lunn Investment Management Ltd. | 528,053 | $1,637 |
| SILVERBACK ASSET MANAGEMENT LLC | 500,000 | $1,550 |
| Invesco Ltd. | 478,909 | $1,485 |
| XTX Topco Ltd | 456,329 | $1,415 |
| Exome Asset Management LLC | 451,699 | $1,400 |
| Bank of New York Mellon Corp | 447,901 | $1,388 |
| JPMORGAN CHASE & CO | 428,903 | $1,330 |
| WELLS FARGO & COMPANY/MN | 361,921 | $1,122 |
| LPL Financial LLC | 358,917 | $1,113 |
| ALGERT GLOBAL LLC | 332,336 | $1 |
| Rafferty Asset Management, LLC | 312,804 | $970 |
| Monaco Asset Management SAM | 309,211 | $959 |
| Nuveen, LLC | 308,522 | $956 |
| MACKENZIE FINANCIAL CORP | 306,453 | $954 |
| SMITH, MOORE & CO. | 280,000 | $868 |
| EAM Investors, LLC | 278,422 | $863 |
| Jain Global LLC | 278,189 | $862 |
| SEI INVESTMENTS CO | 228,896 | $710 |
| Squarepoint Ops LLC | 221,591 | $687 |
| RHUMBLINE ADVISERS | 214,869 | $666 |
| ADAR1 Capital Management, LLC | 212,531 | $659 |
| Atom Investors LP | 205,639 | $637 |
| Stonepine Capital Management, LLC | 204,770 | $635 |
| D. E. Shaw & Co., Inc. | 198,709 | $616 |
| ALLIANCEBERNSTEIN L.P. | 190,220 | $590 |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 176,000 | $546 |
| Russell Investments Group, Ltd. | 171,071 | $530 |
| JANE STREET GROUP, LLC | 155,591 | $482 |
| Merit Financial Group, LLC | 155,178 | $481 |
| PANAGORA ASSET MANAGEMENT INC | 147,296 | $457 |
| Birchview Capital, LP | 138,176 | $428 |
| PRELUDE CAPITAL MANAGEMENT, LLC | 136,200 | $422 |
| Brevan Howard Capital Management LP | 127,299 | $395 |
| PROFUND ADVISORS LLC | 116,503 | $361 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 113,138 | $0 |
| Susquehanna Portfolio Strategies, LLC | 111,350 | $345 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 107,467 | $334 |
| VICTORY CAPITAL MANAGEMENT INC | 105,554 | $327 |
| EntryPoint Capital, LLC | 105,085 | $326 |
| HB Wealth Management, LLC | 95,924 | $297 |
| Lighthouse Investment Partners, LLC | 92,500 | $287 |
| BNP PARIBAS ARBITRAGE, SA | 89,489 | $277 |
| Sequoia Financial Advisors, LLC | 88,467 | $274 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 88,455 | $274 |
| MetLife Investment Management, LLC | 85,645 | $266 |
| INTECH INVESTMENT MANAGEMENT LLC | 85,582 | $265 |
| VARCOV Co. | 83,868 | $260 |
| Caprock Group, LLC | 80,000 | $248 |
| COMMONWEALTH EQUITY SERVICES, LLC | 78,756 | $244 |
| Cambridge Investment Research Advisors, Inc. | 76,940 | $0 |
| Caption Management, LLC | 75,375 | $234 |
| CHOREO, LLC | 75,111 | $234 |
| SG Americas Securities, LLC | 74,129 | $0 |
| Virtus Investment Advisers, LLC | 73,896 | $229 |
| 94 other institutions | 2,000,916 | $5,834 |