| BlackRock, Inc. | 8,855,619 | $1,151,762 |
| FMR LLC | 7,864,164 | $1,022,813 |
| Politan Capital Management LP | 4,589,648 | $596,930 |
| VANGUARD GROUP INC | 4,348,786 | $565,603 |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 2,663,875 | $346,464 |
| NAYA CAPITAL MANAGEMENT UK LTD | 1,560,697 | $202,984 |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 1,522,049 | $197,958 |
| STATE STREET CORP | 1,415,196 | $184,060 |
| Alyeska Investment Group, L.P. | 1,259,307 | $163,785 |
| AQR CAPITAL MANAGEMENT LLC | 1,091,326 | $141,938 |
| GEODE CAPITAL MANAGEMENT, LLC | 953,976 | $124,096 |
| MORGAN STANLEY | 920,735 | $119,751 |
| RTW INVESTMENTS, LP | 683,294 | $88,869 |
| Capital Research Global Investors | 637,894 | $82,964 |
| GOLDMAN SACHS GROUP INC | 636,698 | $82,809 |
| Liontrust Investment Partners LLP | 627,796 | $81,651 |
| T. Rowe Price Investment Management, Inc. | 600,293 | $78 |
| UBS Group AG | 599,274 | $77,942 |
| Squarepoint Ops LLC | 583,747 | $75,922 |
| VIKING GLOBAL INVESTORS LP | 514,340 | $66,895 |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 475,504 | $62,324 |
| AMERIPRISE FINANCIAL INC | 468,407 | $60,921 |
| NORTHERN TRUST CORP | 380,464 | $49,483 |
| NORGES BANK | 377,421 | $49,087 |
| BAMCO INC /NY/ | 373,899 | $48,629 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 361,896 | $47,068 |
| Gotham Asset Management, LLC | 342,194 | $44,506 |
| Corient Private Wealth LLC | 341,730 | $44,445 |
| Invesco Ltd. | 319,308 | $41,529 |
| Bank of New York Mellon Corp | 308,485 | $40,122 |
| Qube Research & Technologies Ltd | 293,536 | $38,177 |
| BANK OF AMERICA CORP /DE/ | 284,702 | $37,028 |
| Schonfeld Strategic Advisors LLC | 265,036 | $34,471 |
| BNP Paribas Investment Partners S.A. | 232,565 | $30 |
| Nuveen, LLC | 224,068 | $29,142 |
| MARSHALL WACE, LLP | 219,312 | $28,524 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 213,594 | $28 |
| Parkman Healthcare Partners LLC | 200,000 | $26,012 |
| Erste Asset Management GmbH | 200,000 | $26,012 |
| MILLENNIUM MANAGEMENT LLC | 187,965 | $24,447 |
| RAYMOND JAMES FINANCIAL INC | 186,510 | $24,258 |
| AMERICAN CENTURY COMPANIES INC | 178,758 | $23,249 |
| DIMENSIONAL FUND ADVISORS LP | 173,950 | $22,625 |
| Man Group plc | 147,416 | $19,173 |
| Grantham, Mayo, Van Otterloo & Co. LLC | 143,825 | $18,706 |
| DF DENT & CO INC | 142,626 | $18,550 |
| RHUMBLINE ADVISERS | 124,556 | $16,200 |
| CITIGROUP INC | 121,231 | $15,767 |
| GW&K Investment Management, LLC | 119,362 | $16 |
| UBS ASSET MANAGEMENT AMERICAS INC | 118,964 | $15,472 |
| JPMORGAN CHASE & CO | 117,798 | $15,321 |
| TD Asset Management Inc | 114,514 | $14,894 |
| JANE STREET GROUP, LLC | 102,881 | $13,381 |
| PRINCIPAL FINANCIAL GROUP INC | 97,858 | $12,727 |
| Bellevue Group AG | 97,285 | $12,653 |
| HRT FINANCIAL LP | 92,776 | $12 |
| Legal & General Group Plc | 92,436 | $12,022 |
| Swiss National Bank | 91,100 | $11,848 |
| Rockefeller Capital Management L.P. | 86,411 | $11,239 |
| Toroso Investments, LLC | 85,294 | $11,093 |
| Engineers Gate Manager LP | 83,458 | $10,855 |
| GAMCO INVESTORS, INC. ET AL | 83,000 | $10,795 |
| Alpha Wave Global, LP | 75,552 | $9,826 |
| D. E. Shaw & Co., Inc. | 66,016 | $8,586 |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 63,359 | $8,240 |
| RENAISSANCE TECHNOLOGIES LLC | 59,900 | $7,791 |
| Swedbank AB | 59,500 | $7,739 |
| BARCLAYS PLC | 58,358 | $7,590 |
| Quantbot Technologies LP | 56,925 | $7,404 |
| Retirement Systems of Alabama | 54,795 | $7,127 |
| ALLIANCEBERNSTEIN L.P. | 54,223 | $7,052 |
| Assenagon Asset Management S.A. | 53,525 | $6,961 |
| Verition Fund Management LLC | 53,020 | $6,896 |
| BLI - Banque de Luxembourg Investments | 48,839 | $6,400 |
| CAPITAL FUND MANAGEMENT S.A. | 47,586 | $6,189 |
| Sofinnova Investments, Inc. | 46,201 | $6,009 |
| Amundi | 43,860 | $5,704 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 43,823 | $5,700 |
| CITADEL ADVISORS LLC | 43,052 | $5,599 |
| NS Partners Ltd | 42,348 | $5,508 |
| Walleye Capital LLC | 42,049 | $5,469 |
| NEW YORK STATE TEACHERS RETIREMENT SYSTEM | 40,048 | $5 |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 39,749 | $5,170 |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 39,557 | $5,145 |
| WILSON ASSET MANAGEMENT (INTERNATIONAL) PTY LTD | 39,437 | $5,129 |
| CANADA PENSION PLAN INVESTMENT BOARD | 38,500 | $5,007 |
| STRS OHIO | 36,915 | $4,801 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 33,184 | $4,316 |
| GABELLI FUNDS LLC | 32,700 | $4,253 |
| Baird Financial Group, Inc. | 30,679 | $3,990 |
| NORDEA INVESTMENT MANAGEMENT AB | 28,319 | $3,690 |
| Campbell & CO Investment Adviser LLC | 27,783 | $3,613 |
| GREAT WEST LIFE ASSURANCE CO /CAN/ | 26,610 | $3 |
| LOGAN CAPITAL MANAGEMENT INC | 26,505 | $3,447 |
| GLUSKIN SHEFF & ASSOC INC | 25,805 | $3,356 |
| INTECH INVESTMENT MANAGEMENT LLC | 24,765 | $3,221 |
| MetLife Investment Management, LLC | 24,472 | $3,183 |
| Westmount Partners, LLC | 24,232 | $3,152 |
| NEW YORK STATE COMMON RETIREMENT FUND | 24,160 | $3,142 |
| Cerity Partners LLC | 23,774 | $3,092 |
| 287 other institutions | 1,389,017 | $155,002 |