Ticker: SYRE CUSIP: 00773J202 Class: Common Stock
Note: Option positions (PUT/CALL) are excluded.
| Institution | Shares | Value ($000) |
|---|---|---|
| CAXTON CORP | 8,919 | $292 |
| Patient Square Capital LP | 150,000 | $4,914 |
| SILVERARC CAPITAL MANAGEMENT, LLC | 187,737 | $6,150 |
| RA CAPITAL MANAGEMENT, L.P. | 1,621,620 | $53,124 |
| SEVEN GRAND MANAGERS, LLC | 100,000 | $3,276 |
| STEMPOINT CAPITAL LP | 32,377 | $1,061 |
| Neo Ivy Capital Management | 18,261 | $598 |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. | 13,724 | $450 |
| Cinctive Capital Management LP | 35,935 | $1,177 |
| Point72 Asset Management, L.P. | 662,351 | $21,699 |
| Persistent Asset Partners Ltd | 2,246 | $74 |
| ALPS ADVISORS INC | 63,708 | $2,087 |
| BALYASNY ASSET MANAGEMENT L.P. | 73,465 | $2,407 |
| MARTINGALE ASSET MANAGEMENT L P | 6,930 | $227 |
| Carlyle Group Inc. | 9,620 | $315 |
| CITADEL ADVISORS LLC | 63,904 | $2,093 |
| State of New Jersey Common Pension Fund D | 16,698 | $547 |
| Voya Investment Management LLC | 27,277 | $894 |
| AMERIPRISE FINANCIAL INC | 38,256 | $1,253 |
| Brevan Howard Capital Management LP | 6,198 | $203 |
| Institution | Prev Shares | Curr Shares | Change |
|---|---|---|---|
| VR Adviser, LLC | 2,685,448 | 3,685,448 | +1,000,000 (+37.2%) |
| Commodore Capital LP | 1,988,084 | 2,388,245 | +400,161 (+20.1%) |
| PERCEPTIVE ADVISORS LLC | 1,229,445 | 3,069,225 | +1,839,780 (+149.6%) |
| TCG Crossover Management, LLC | 1,100,582 | 1,900,582 | +800,000 (+72.7%) |
| Siren, L.L.C. | 368,598 | 818,598 | +450,000 (+122.1%) |
| RTW INVESTMENTS, LP | 3,621,996 | 4,171,996 | +550,000 (+15.2%) |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 2,060,375 | 2,882,420 | +822,045 (+39.9%) |
| EMERALD MUTUAL FUND ADVISERS TRUST | 308,212 | 412,371 | +104,159 (+33.8%) |
| EMERALD ADVISERS, LLC | 548,712 | 636,109 | +87,397 (+15.9%) |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 613,665 | 710,626 | +96,961 (+15.8%) |
| F/M Investments LLC | 54,893 | 103,718 | +48,825 (+88.9%) |
| JANUS HENDERSON GROUP PLC | 13,000 | 1,829,009 | +1,816,009 (+13969.3%) |
| Woodline Partners LP | 131,876 | 265,892 | +134,016 (+101.6%) |
| ARMISTICE CAPITAL, LLC | 156,000 | 196,426 | +40,426 (+25.9%) |
| FMR LLC | 9,060,144 | 11,638,819 | +2,578,675 (+28.5%) |
| Capital International Investors | 2,392,541 | 3,492,541 | +1,100,000 (+46.0%) |
| Susquehanna Portfolio Strategies, LLC | 21,739 | 53,101 | +31,362 (+144.3%) |
| BlackRock, Inc. | 3,982,744 | 5,522,101 | +1,539,357 (+38.7%) |
| Optimize Financial Inc | 24,967 | 25,331 | +364 (+1.5%) |
| FRANKLIN RESOURCES INC | 795,275 | 1,109,274 | +313,999 (+39.5%) |
| Institution | Prev Shares | Curr Shares | Change |
|---|---|---|---|
| TANG CAPITAL MANAGEMENT LLC | 3,200,000 | 1,892,200 | -1,307,800 (-40.9%) |
| BRAIDWELL LP | 2,578,404 | 1,634,615 | -943,789 (-36.6%) |
| HighVista Strategies LLC | 215,746 | 188,206 | -27,540 (-12.8%) |
| Parkman Healthcare Partners LLC | 200,753 | 124,485 | -76,268 (-38.0%) |
| AlphaQuest LLC | 66,163 | 3,538 | -62,625 (-94.7%) |
| Polar Capital Holdings Plc | 788,788 | 740,326 | -48,462 (-6.1%) |
| BNP PARIBAS ARBITRAGE, SA | 315,909 | 11,844 | -304,065 (-96.3%) |
| MILLENNIUM MANAGEMENT LLC | 408,199 | 76,194 | -332,005 (-81.3%) |
| ExodusPoint Capital Management, LP | 68,563 | 37,871 | -30,692 (-44.8%) |
| Pictet Asset Management Holding SA | 1,036,218 | 913,960 | -122,258 (-11.8%) |
| VICTORY CAPITAL MANAGEMENT INC | 326,081 | 146,079 | -180,002 (-55.2%) |
| JPMORGAN CHASE & CO | 275,984 | 62,951 | -213,033 (-77.2%) |
| MORGAN STANLEY | 334,722 | 182,734 | -151,988 (-45.4%) |
| WELLINGTON MANAGEMENT GROUP LLP | 1,640,312 | 1,549,284 | -91,028 (-5.5%) |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 107,738 | 61,574 | -46,164 (-42.8%) |
| GOLDMAN SACHS GROUP INC | 329,533 | 275,065 | -54,468 (-16.5%) |
| Tower Research Capital LLC (TRC) | 4,596 | 425 | -4,171 (-90.8%) |
| Rafferty Asset Management, LLC | 59,667 | 53,410 | -6,257 (-10.5%) |
| STATE OF WISCONSIN INVESTMENT BOARD | 33,546 | 27,252 | -6,294 (-18.8%) |
| DIMENSIONAL FUND ADVISORS LP | 84,216 | 77,290 | -6,926 (-8.2%) |
| Institution | Prev Shares | Prev Value ($000) |
|---|---|---|
| Jefferies Financial Group Inc. | 1,388,854 | $23,277 |
| Opaleye Management Inc. | 65,000 | $1,089 |
| DLD Asset Management, LP | 30,000 | $503 |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 264,317 | $4,430 |
| Schonfeld Strategic Advisors LLC | 81,474 | $1,366 |
| DARK FOREST CAPITAL MANAGEMENT LP | 14,733 | $247 |
| Jump Financial, LLC | 27,100 | $454 |
| Verition Fund Management LLC | 48,496 | $813 |
| nVerses Capital, LLC | 500 | $15 |
| Quadrature Capital Ltd | 19,366 | $325 |
| DRW Securities, LLC | 11,475 | $190 |
| JANE STREET GROUP, LLC | 96,057 | $1,610 |
| Squarepoint Ops LLC | 20,232 | $339 |
| HUNTINGTON NATIONAL BANK | 1,470 | $25 |
| SRS Capital Advisors, Inc. | 121 | $2 |