| RA CAPITAL MANAGEMENT, L.P. | 5,653,211 | $42,399 |
| JANUS HENDERSON GROUP PLC | 4,635,875 | $34,726 |
| BVF INC/IL | 4,629,289 | $34,720 |
| GOLDMAN SACHS GROUP INC | 4,302,905 | $32,272 |
| BlackRock, Inc. | 4,064,876 | $30,487 |
| Novo Holdings A/S | 3,650,737 | $27,381 |
| VANGUARD GROUP INC | 3,093,527 | $23,201 |
| STATE STREET CORP | 2,688,880 | $20,167 |
| ARMISTICE CAPITAL, LLC | 1,936,000 | $14,520 |
| FEDERATED HERMES, INC. | 1,609,482 | $12,071 |
| Point72 Asset Management, L.P. | 1,539,860 | $11,549 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,235,156 | $9,264 |
| GEODE CAPITAL MANAGEMENT, LLC | 1,012,025 | $7,592 |
| Evergreen Quality Fund GP, Ltd. | 951,474 | $7,136 |
| BANK OF AMERICA CORP /DE/ | 832,591 | $6,244 |
| DEUTSCHE BANK AG\ | 704,207 | $5,282 |
| MORGAN STANLEY | 672,695 | $5,045 |
| RENAISSANCE TECHNOLOGIES LLC | 512,900 | $3,847 |
| Parkman Healthcare Partners LLC | 503,431 | $3,776 |
| ArrowMark Colorado Holdings LLC | 485,389 | $3,640 |
| RAYMOND JAMES FINANCIAL INC | 477,505 | $3,581 |
| BAKER BROS. ADVISORS LP | 475,737 | $3,568 |
| RTW INVESTMENTS, LP | 475,737 | $3,568 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 353,391 | $2,650 |
| TWO SIGMA INVESTMENTS, LP | 337,503 | $2,531 |
| NORTHERN TRUST CORP | 313,820 | $2,354 |
| Assenagon Asset Management S.A. | 296,199 | $2,221 |
| DIMENSIONAL FUND ADVISORS LP | 294,841 | $2,211 |
| JPMORGAN CHASE & CO | 279,505 | $2,096 |
| TWO SIGMA ADVISERS, LP | 275,300 | $2,065 |
| Burkehill Global Management, LP | 275,000 | $2,063 |
| Peapod Lane Capital LLC | 268,024 | $2,010 |
| UBS Group AG | 231,292 | $1,735 |
| JANE STREET GROUP, LLC | 224,903 | $1,687 |
| Privium Fund Management B.V. | 210,000 | $1,575 |
| Woodline Partners LP | 200,001 | $1,500 |
| BARCLAYS PLC | 170,639 | $1,280 |
| Schonfeld Strategic Advisors LLC | 161,982 | $1,215 |
| Nuveen, LLC | 158,769 | $1,191 |
| Invesco Ltd. | 153,142 | $1,149 |
| Perigon Wealth Management, LLC | 146,133 | $1,096 |
| Bank of New York Mellon Corp | 136,739 | $1,026 |
| WELLINGTON MANAGEMENT GROUP LLP | 130,252 | $977 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 126,013 | $945 |
| ADAR1 Capital Management, LLC | 116,712 | $875 |
| D. E. Shaw & Co., Inc. | 111,822 | $839 |
| SILVERARC CAPITAL MANAGEMENT, LLC | 100,000 | $750 |
| MILLENNIUM MANAGEMENT LLC | 96,364 | $723 |
| AMERICAN CENTURY COMPANIES INC | 91,084 | $683 |
| Rafferty Asset Management, LLC | 83,413 | $626 |
| Engineers Gate Manager LP | 74,269 | $557 |
| Squarepoint Ops LLC | 71,721 | $538 |
| FMR LLC | 65,649 | $492 |
| XTX Topco Ltd | 65,022 | $488 |
| ALLIANCEBERNSTEIN L.P. | 55,100 | $413 |
| RHUMBLINE ADVISERS | 53,845 | $404 |
| Principia Wealth Advisory, LLC | 53,668 | $403 |
| Walleye Capital LLC | 50,762 | $381 |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 50,000 | $375 |
| PANAGORA ASSET MANAGEMENT INC | 46,979 | $352 |
| WELLS FARGO & COMPANY/MN | 46,620 | $350 |
| Quantinno Capital Management LP | 46,300 | $347 |
| Decheng Capital LLC | 44,311 | $332 |
| Creative Planning | 44,195 | $331 |
| Jain Global LLC | 40,464 | $303 |
| ExodusPoint Capital Management, LP | 39,175 | $294 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 38,747 | $0 |
| Rangeley Capital, LLC | 38,665 | $290 |
| AQR CAPITAL MANAGEMENT LLC | 36,084 | $271 |
| Jump Financial, LLC | 33,830 | $254 |
| TUDOR INVESTMENT CORP ET AL | 31,815 | $239 |
| PROFUND ADVISORS LLC | 30,851 | $231 |
| AXQ CAPITAL, LP | 30,755 | $231 |
| ACADIAN ASSET MANAGEMENT LLC | 30,131 | $0 |
| DekaBank Deutsche Girozentrale | 30,000 | $1 |
| HARBOR CAPITAL ADVISORS, INC. | 29,716 | $0 |
| Thrivent Financial for Lutherans | 28,938 | $0 |
| MARSHALL WACE, LLP | 27,758 | $208 |
| Man Group plc | 27,034 | $203 |
| STRS OHIO | 25,100 | $188 |
| MetLife Investment Management, LLC | 25,092 | $188 |
| TRUIST FINANCIAL CORP | 25,000 | $188 |
| Peloton Wealth Strategists | 25,000 | $0 |
| Virtus Investment Advisers, LLC | 24,541 | $184 |
| Kera Capital Partners, Inc. | 24,068 | $213 |
| Mitsubishi UFJ Kokusai Asset Management Co., Ltd. | 23,845 | $175 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 23,538 | $177 |
| EntryPoint Capital, LLC | 22,324 | $167 |
| PDT Partners, LLC | 20,097 | $151 |
| COMMONWEALTH EQUITY SERVICES, LLC | 20,009 | $150 |
| CITADEL ADVISORS LLC | 19,889 | $149 |
| Landing Point Financial Group, LLC | 19,000 | $143 |
| Rockefeller Capital Management L.P. | 18,054 | $135 |
| Polymer Capital Management (US) LLC | 18,035 | $135 |
| Parallel Advisors, LLC | 17,887 | $134 |
| INTECH INVESTMENT MANAGEMENT LLC | 17,628 | $132 |
| Ballentine Partners, LLC | 16,529 | $124 |
| DnB Asset Management AS | 16,123 | $121 |
| PRELUDE CAPITAL MANAGEMENT, LLC | 15,770 | $118 |
| AlphaQuest LLC | 15,731 | $118 |
| 51 other institutions | 242,343 | $1,652 |