| FMR LLC | 51,424,981 | $460,768 |
| Decheng Capital LLC | 25,954,439 | $232,552 |
| BlackRock, Inc. | 24,669,776 | $221,041 |
| VANGUARD GROUP INC | 15,555,606 | $139,378 |
| Omega Fund Management, LLC | 8,081,089 | $72,407 |
| Laurion Capital Management LP | 7,852,638 | $70,360 |
| STATE STREET CORP | 5,858,782 | $52,495 |
| GEODE CAPITAL MANAGEMENT, LLC | 5,712,296 | $51,192 |
| TANG CAPITAL MANAGEMENT LLC | 3,857,457 | $34,563 |
| ABRAMS CAPITAL MANAGEMENT, L.P. | 3,811,513 | $34,151 |
| BANK OF AMERICA CORP /DE/ | 3,809,425 | $34,132 |
| Redmile Group, LLC | 3,163,256 | $28,343 |
| Nuveen, LLC | 2,852,001 | $25,554 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,708,553 | $24 |
| DIMENSIONAL FUND ADVISORS LP | 2,066,360 | $18,515 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 2,016,681 | $18,069 |
| NORTHERN TRUST CORP | 1,921,732 | $17,219 |
| GOLDMAN SACHS GROUP INC | 1,696,013 | $15,196 |
| AQR CAPITAL MANAGEMENT LLC | 1,669,166 | $14,956 |
| Capricorn Fund Managers Ltd | 1,588,854 | $14,236 |
| Knoll Capital Management, LLC | 1,498,591 | $13,427 |
| Qube Research & Technologies Ltd | 1,280,899 | $11,477 |
| MORGAN STANLEY | 1,276,128 | $11,434 |
| ARMISTICE CAPITAL, LLC | 1,263,737 | $11,323 |
| SymBiosis Capital Partners, LLC | 1,250,000 | $11,200 |
| MARSHALL WACE, LLP | 1,234,273 | $11,059 |
| Invesco Ltd. | 1,185,143 | $10,619 |
| Woodline Partners LP | 957,914 | $8,583 |
| NewEdge Advisors, LLC | 952,166 | $8,531 |
| WELLINGTON MANAGEMENT GROUP LLP | 899,988 | $8,064 |
| D. E. Shaw & Co., Inc. | 875,802 | $7,847 |
| TANAKA CAPITAL MANAGEMENT INC | 841,605 | $8 |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 819,632 | $7,344 |
| TWO SIGMA INVESTMENTS, LP | 735,945 | $6,594 |
| MILLENNIUM MANAGEMENT LLC | 711,544 | $6,375 |
| BNP PARIBAS ARBITRAGE, SA | 702,017 | $6,290 |
| Bank of New York Mellon Corp | 687,228 | $6,158 |
| UBS Group AG | 615,402 | $5,514 |
| ACT CAPITAL MANAGEMENT, LLC | 610,500 | $5,470 |
| JPMORGAN CHASE & CO | 595,045 | $5,332 |
| Neo Ivy Capital Management | 587,656 | $5,265 |
| CAXTON ASSOCIATES LLP | 584,935 | $5,241 |
| SummitTX Capital, L.P. | 578,304 | $5,182 |
| Palo Alto Investors LP | 538,079 | $4,821 |
| JANE STREET GROUP, LLC | 530,077 | $4,749 |
| UBS ASSET MANAGEMENT AMERICAS INC | 521,038 | $4,669 |
| Hennion & Walsh Asset Management, Inc. | 445,279 | $3,990 |
| BARCLAYS PLC | 439,272 | $3,936 |
| Swiss National Bank | 437,400 | $3,919 |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 408,922 | $3,664 |
| EAM Investors, LLC | 404,019 | $3,620 |
| Ishara Investments LP | 400,000 | $3,584 |
| TWO SIGMA ADVISERS, LP | 393,100 | $3,522 |
| TD Asset Management Inc | 312,400 | $2,799 |
| RHUMBLINE ADVISERS | 308,189 | $2,761 |
| ALGERT GLOBAL LLC | 291,108 | $3 |
| Intellectus Partners, LLC | 285,417 | $2,557 |
| ALPS ADVISORS INC | 280,900 | $2,517 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 278,831 | $2,494 |
| IEQ CAPITAL, LLC | 274,061 | $2,456 |
| WELLS FARGO & COMPANY/MN | 271,937 | $2,437 |
| Beacon Pointe Advisors, LLC | 259,212 | $2,323 |
| STATE OF WISCONSIN INVESTMENT BOARD | 256,986 | $2,303 |
| Corient Private Wealth LLC | 254,103 | $2,277 |
| NEOS Investment Management LLC | 247,508 | $2,218 |
| TEMA ETFS LLC | 243,848 | $2,185 |
| ALLIANCEBERNSTEIN L.P. | 229,089 | $2,053 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 213,670 | $1,914 |
| Legal & General Group Plc | 192,867 | $1,728 |
| Connor, Clark & Lunn Investment Management Ltd. | 191,998 | $1,720 |
| DEUTSCHE BANK AG\ | 190,817 | $1,710 |
| Trexquant Investment LP | 186,887 | $1,675 |
| DARK FOREST CAPITAL MANAGEMENT LP | 185,843 | $1,665 |
| Jump Financial, LLC | 169,600 | $1,520 |
| Palumbo Wealth Management LLC | 163,756 | $1,467 |
| MetLife Investment Management, LLC | 138,178 | $1,238 |
| CITADEL ADVISORS LLC | 134,999 | $1,210 |
| WEXFORD CAPITAL LP | 130,000 | $1,165 |
| Verition Fund Management LLC | 125,216 | $1,122 |
| Cresset Asset Management, LLC | 118,640 | $1,063 |
| Meridian Wealth Management, LLC | 113,565 | $1,018 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 112,040 | $1,004 |
| JANUS HENDERSON GROUP PLC | 108,400 | $972 |
| Creative Planning | 107,714 | $965 |
| Wealthcare Advisory Partners LLC | 106,952 | $958 |
| CWM, LLC | 102,378 | $1 |
| Voya Investment Management LLC | 99,780 | $894 |
| Cerity Partners LLC | 96,652 | $866 |
| INTECH INVESTMENT MANAGEMENT LLC | 90,415 | $810 |
| SEI INVESTMENTS CO | 84,166 | $754 |
| Virtus Investment Advisers, LLC | 81,068 | $726 |
| State of New Jersey Common Pension Fund D | 75,714 | $678 |
| NEW YORK STATE COMMON RETIREMENT FUND | 68,728 | $616 |
| Perigon Wealth Management, LLC | 68,147 | $611 |
| Police & Firemen's Retirement System of New Jersey | 66,203 | $593 |
| CITIGROUP INC | 63,082 | $565 |
| Arizona State Retirement System | 62,462 | $560 |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 62,395 | $530 |
| SG Americas Securities, LLC | 61,791 | $1 |
| RAYMOND JAMES FINANCIAL INC | 60,671 | $544 |
| 121 other institutions | 2,026,410 | $17,223 |