SCHRODINGER INC

Institution	Shares	Value ($000)
PERCEPTIVE ADVISORS LLC	202,400	$3,619
INCEPTIONR LLC	19,717	$353
Trexquant Investment LP	135,024	$2,414
WESBANCO BANK INC	46,900	$839
MIRABELLA FINANCIAL SERVICES LLP	13,542	$242
Aquatic Capital Management LLC	38,058	$680
ExodusPoint Capital Management, LP	62,483	$1,117
GSA CAPITAL PARTNERS LLP	26,765	$0
Graham Capital Management, L.P.	31,294	$560
Allianz Asset Management GmbH	248,053	$4,435
DEERFIELD MANAGEMENT COMPANY, L.P.	33,987	$608
ROYCE & ASSOCIATES LP	29,009	$519
Point72 Asset Management, L.P.	37,382	$668
Pinnacle Wealth Planning Services, Inc.	812	$15
LOS ANGELES CAPITAL MANAGEMENT LLC	1,458	$30
CIBC Private Wealth Group, LLC	1,233	$22
HARBOUR INVESTMENTS, INC.	95	$2
Cedar Mountain Advisors, LLC	4	$0
Dunhill Financial, LLC	1	$0
Clearstead Advisors, LLC	1	$0

Increased Positions (75)

EntryPoint Capital, LLC

Value ($000) $792 (+156.6%) Shares 44,319 (+187.9%)

Slow Capital, Inc.

Value ($000) $2,347 (+24.6%) Shares 131,263 (+39.8%)

Nikko Asset Management Americas, Inc.

Value ($000) $50,359 (-4.9%) Shares 2,819,670 (+6.8%)

FOX RUN MANAGEMENT, L.L.C.

Value ($000) $855 (+139.7%) Shares 47,831 (+168.9%)

ARK Investment Management LLC

Value ($000) $37,760 (+0.5%) Shares 2,111,829 (+12.8%)

Susquehanna Portfolio Strategies, LLC

Value ($000) $2,828 (+398.4%) Shares 158,162 (+459.2%)

Stephens Investment Management Group LLC

Value ($000) $40,232 (-8.5%) Shares 2,250,098 (+2.6%)

IQ EQ FUND MANAGEMENT (IRELAND) Ltd

Value ($000) $1,229 (+48.1%) Shares 68,759 (+66.2%)

ALGERT GLOBAL LLC

Value ($000) $4 (+455.9%) Shares 211,427 (+523.9%)

FRED ALGER MANAGEMENT, LLC

Value ($000) $4,824 (+133.2%) Shares 269,825 (+161.7%)

Man Group plc

Value ($000) $7,892 (+141.1%) Shares 441,363 (+170.5%)

Connor, Clark & Lunn Investment Management Ltd.

Value ($000) $4,886 (+178.0%) Shares 273,254 (+211.9%)

Engineers Gate Manager LP

Value ($000) $1,169 (+336.2%) Shares 65,399 (+389.4%)

Verity Asset Management, Inc.

Value ($000) $1,175 (-9.8%) Shares 65,722 (+1.2%)

UBS ASSET MANAGEMENT AMERICAS INC

Value ($000) $66,476 (+0.3%) Shares 3,717,890 (+12.5%)

UBS Group AG

Value ($000) $25,797 (+34.8%) Shares 1,442,799 (+51.3%)

TUDOR INVESTMENT CORP ET AL

Value ($000) $7,848 (+16.3%) Shares 438,925 (+30.5%)

Sumitomo Mitsui Trust Holdings, Inc.

Value ($000) $84,300 (-7.7%) Shares 4,714,767 (+3.5%)

MASSACHUSETTS FINANCIAL SERVICES CO /MA/

Value ($000) $40,969 (-1.5%) Shares 2,291,349 (+10.6%)

Schonfeld Strategic Advisors LLC

Value ($000) $1,174 (+121.5%) Shares 65,640 (+148.6%)

Institution	Prev Shares	Curr Shares	Change
EntryPoint Capital, LLC	15,395	44,319	+28,924 (+187.9%)
Slow Capital, Inc.	93,889	131,263	+37,374 (+39.8%)
Nikko Asset Management Americas, Inc.	2,638,935	2,819,670	+180,735 (+6.8%)
FOX RUN MANAGEMENT, L.L.C.	17,789	47,831	+30,042 (+168.9%)
ARK Investment Management LLC	1,872,677	2,111,829	+239,152 (+12.8%)
Susquehanna Portfolio Strategies, LLC	28,285	158,162	+129,877 (+459.2%)
Stephens Investment Management Group LLC	2,193,034	2,250,098	+57,064 (+2.6%)
IQ EQ FUND MANAGEMENT (IRELAND) Ltd	41,374	68,759	+27,385 (+66.2%)
ALGERT GLOBAL LLC	33,890	211,427	+177,537 (+523.9%)
FRED ALGER MANAGEMENT, LLC	103,119	269,825	+166,706 (+161.7%)
Man Group plc	163,174	441,363	+278,189 (+170.5%)
Connor, Clark & Lunn Investment Management Ltd.	87,622	273,254	+185,632 (+211.9%)
Engineers Gate Manager LP	13,364	65,399	+52,035 (+389.4%)
Verity Asset Management, Inc.	64,924	65,722	+798 (+1.2%)
UBS ASSET MANAGEMENT AMERICAS INC	3,303,659	3,717,890	+414,231 (+12.5%)
UBS Group AG	953,740	1,442,799	+489,059 (+51.3%)
TUDOR INVESTMENT CORP ET AL	336,379	438,925	+102,546 (+30.5%)
Sumitomo Mitsui Trust Holdings, Inc.	4,554,569	4,714,767	+160,198 (+3.5%)
MASSACHUSETTS FINANCIAL SERVICES CO /MA/	2,072,433	2,291,349	+218,916 (+10.6%)
Schonfeld Strategic Advisors LLC	26,408	65,640	+39,232 (+148.6%)

Decreased Positions (75)

Rubric Capital Management LP

Value ($000) $74,586 (-29.4%) Shares 4,171,498 (-20.8%)

Tejara Capital Ltd

Value ($000) $2,176 (-16.4%) Shares 121,697 (-6.2%)

Parkman Healthcare Partners LLC

Value ($000) $5,345 (-21.7%) Shares 298,939 (-12.1%)

FARALLON CAPITAL MANAGEMENT LLC

Value ($000) $1,269 (-77.7%) Shares 71,000 (-75.0%)

XTX Topco Ltd

Value ($000) $474 (-55.9%) Shares 26,530 (-50.5%)

TWO SIGMA INVESTMENTS, LP

Value ($000) $7,810 (-50.8%) Shares 436,792 (-44.8%)

TWO SIGMA ADVISERS, LP

Value ($000) $9,058 (-39.1%) Shares 506,600 (-31.6%)

PIER 88 INVESTMENT PARTNERS LLC

Value ($000) $910 (-16.3%) Shares 50,870 (-6.1%)

LAZARD ASSET MANAGEMENT LLC

Value ($000) $38,173 (-18.9%) Shares 2,134,968 (-9.0%)

MILLENNIUM MANAGEMENT LLC

Value ($000) $17,490 (-43.8%) Shares 978,172 (-37.0%)

United Advisor Group, LLC

Value ($000) $258 (-34.5%) Shares 14,439 (-26.5%)

MORGAN STANLEY

Value ($000) $21,218 (-39.1%) Shares 1,186,698 (-31.7%)

ROYAL BANK OF CANADA

Value ($000) $922 (-89.3%) Shares 51,571 (-88.0%)

BAILLIE GIFFORD & CO

Value ($000) $14,939 (-23.6%) Shares 835,488 (-14.3%)

TOCQUEVILLE ASSET MANAGEMENT L.P.

Value ($000) $2,807 (-18.8%) Shares 157,000 (-8.9%)

JANE STREET GROUP, LLC

Value ($000) $1,622 (-67.0%) Shares 90,716 (-62.9%)

CITADEL ADVISORS LLC

Value ($000) $3,360 (-41.5%) Shares 187,915 (-34.4%)

Public Sector Pension Investment Board

Value ($000) $3,473 (-20.8%) Shares 194,267 (-11.1%)

STATE STREET CORP

Value ($000) $38,118 (-13.8%) Shares 2,131,906 (-3.3%)

Nuveen, LLC

Value ($000) $2,236 (-39.3%) Shares 125,040 (-31.9%)

Institution	Prev Shares	Curr Shares	Change
Rubric Capital Management LP	5,268,817	4,171,498	-1,097,319 (-20.8%)
Tejara Capital Ltd	129,697	121,697	-8,000 (-6.2%)
Parkman Healthcare Partners LLC	340,187	298,939	-41,248 (-12.1%)
FARALLON CAPITAL MANAGEMENT LLC	284,000	71,000	-213,000 (-75.0%)
XTX Topco Ltd	53,596	26,530	-27,066 (-50.5%)
TWO SIGMA INVESTMENTS, LP	791,064	436,792	-354,272 (-44.8%)
TWO SIGMA ADVISERS, LP	741,100	506,600	-234,500 (-31.6%)
PIER 88 INVESTMENT PARTNERS LLC	54,190	50,870	-3,320 (-6.1%)
LAZARD ASSET MANAGEMENT LLC	2,346,441	2,134,968	-211,473 (-9.0%)
MILLENNIUM MANAGEMENT LLC	1,551,721	978,172	-573,549 (-37.0%)
United Advisor Group, LLC	19,649	14,439	-5,210 (-26.5%)
MORGAN STANLEY	1,737,430	1,186,698	-550,732 (-31.7%)
ROYAL BANK OF CANADA	428,830	51,571	-377,259 (-88.0%)
BAILLIE GIFFORD & CO	974,795	835,488	-139,307 (-14.3%)
TOCQUEVILLE ASSET MANAGEMENT L.P.	172,250	157,000	-15,250 (-8.9%)
JANE STREET GROUP, LLC	244,804	90,716	-154,088 (-62.9%)
CITADEL ADVISORS LLC	286,351	187,915	-98,436 (-34.4%)
Public Sector Pension Investment Board	218,641	194,267	-24,374 (-11.1%)
STATE STREET CORP	2,205,034	2,131,906	-73,128 (-3.3%)
Nuveen, LLC	183,480	125,040	-58,440 (-31.9%)

Exited Positions (30)

Bayforest Capital Ltd

Value ($000) $353 Shares 17,581

Prosight Management, LP

Value ($000) $699 Shares 34,830

PharVision Advisers, LLC

Value ($000) $286 Shares 14,254

Campbell & CO Investment Adviser LLC

Value ($000) $1,732 Shares 86,319

Palumbo Wealth Management LLC

Value ($000) $289 Shares 14,390

Sciencast Management LP

Value ($000) $295 Shares 14,714

GREENWOOD CAPITAL ASSOCIATES LLC

Value ($000) $400 Shares 19,917

State of Wyoming

Value ($000) $154 Shares 7,692

Universal- Beteiligungs- und Servicegesellschaft mbH

Value ($000) $4,139 Shares 206,334

Aster Capital Management (DIFC) Ltd

Value ($000) $39 Shares 1,943

Quarry LP

Value ($000) $48 Shares 2,401

Creative Planning

Value ($000) $513 Shares 25,588

NORGES BANK

Value ($000) $311 Shares 15,437

BANK OF MONTREAL /CAN/

Value ($000) $214 Shares 10,685

FEDERATED HERMES, INC.

Value ($000) $120 Shares 6,000

CANADA PENSION PLAN INVESTMENT BOARD

Value ($000) $118 Shares 5,900

Wealthspire Advisors, LLC

Value ($000) $15 Shares 766

Caitong International Asset Management Co., Ltd

Value ($000) $3 Shares 161

Advisory Services Network, LLC

Value ($000) $7 Shares 340

Optiver Holding B.V.

Value ($000) $6 Shares 293

Institution	Prev Shares	Prev Value ($000)
Bayforest Capital Ltd	17,581	$353
Prosight Management, LP	34,830	$699
PharVision Advisers, LLC	14,254	$286
Campbell & CO Investment Adviser LLC	86,319	$1,732
Palumbo Wealth Management LLC	14,390	$289
Sciencast Management LP	14,714	$295
GREENWOOD CAPITAL ASSOCIATES LLC	19,917	$400
State of Wyoming	7,692	$154
Universal- Beteiligungs- und Servicegesellschaft mbH	206,334	$4,139
Aster Capital Management (DIFC) Ltd	1,943	$39
Quarry LP	2,401	$48
Creative Planning	25,588	$513
NORGES BANK	15,437	$311
BANK OF MONTREAL /CAN/	10,685	$214
FEDERATED HERMES, INC.	6,000	$120
CANADA PENSION PLAN INVESTMENT BOARD	5,900	$118
Wealthspire Advisors, LLC	766	$15
Caitong International Asset Management Co., Ltd	161	$3
Advisory Services Network, LLC	340	$7
Optiver Holding B.V.	293	$6