UPSTREAM BIO INC

Institution	Shares	Value ($000)
Boxer Capital Management, LLC	150,000	$4,073
Vestal Point Capital, LP	720,000	$19,548
Artia Global Partners LP	68,653	$1,864
SEVEN GRAND MANAGERS, LLC	50,000	$1,358
Persistent Asset Partners Ltd	8,907	$242
DIADEMA PARTNERS LP	20,500	$557
JANUS HENDERSON GROUP PLC	1,527,958	$41,423
Pictet Asset Management Holding SA	773,148	$20,991
Alyeska Investment Group, L.P.	298,329	$8,100
Y-Intercept (Hong Kong) Ltd	46,559	$1,264
ExodusPoint Capital Management, LP	75,402	$2,047
China Universal Asset Management Co., Ltd.	8,806	$239
XTX Topco Ltd	15,091	$410
PROFUND ADVISORS LLC	14,582	$396
BARCLAYS PLC	524,499	$14,240
JENNISON ASSOCIATES LLC	288,847	$7,842
Trexquant Investment LP	31,049	$843
Graham Capital Management, L.P.	13,712	$372
AMERIPRISE FINANCIAL INC	56,557	$1,536
SUSQUEHANNA INTERNATIONAL GROUP, LLP	55,841	$1,516

Increased Positions (39)

Integral Health Asset Management, LLC

Value ($000) $20,363 (+88.3%) Shares 750,000 (+30.4%)

Exome Asset Management LLC

Value ($000) $1,761 (+80.1%) Shares 64,845 (+24.8%)

Woodline Partners LP

Value ($000) $20,641 (+82.2%) Shares 760,252 (+26.2%)

UBS Group AG

Value ($000) $49,039 (+857.5%) Shares 1,806,243 (+563.4%)

NORGES BANK

Value ($000) $78,264 (+634.9%) Shares 2,882,647 (+197.2%)

MILLENNIUM MANAGEMENT LLC

Value ($000) $14,044 (+1761.3%) Shares 517,264 (+1189.5%)

BlackRock, Inc.

Value ($000) $90,803 (+85.4%) Shares 3,344,504 (+28.5%)

STATE STREET CORP

Value ($000) $35,817 (+70.8%) Shares 1,319,226 (+18.4%)

Invesco Ltd.

Value ($000) $4,431 (+1270.2%) Shares 163,186 (+849.3%)

DEUTSCHE BANK AG\

Value ($000) $3,470 (+590.0%) Shares 127,815 (+378.0%)

GOLDMAN SACHS GROUP INC

Value ($000) $9,054 (+115.6%) Shares 333,481 (+49.4%)

SummitTX Capital, L.P.

Value ($000) $3,169 (+49.9%) Shares 116,724 (+3.8%)

ALPS ADVISORS INC

Value ($000) $1,205 (+146.7%) Shares 44,376 (+70.9%)

JPMORGAN CHASE & CO

Value ($000) $2,994 (+431.5%) Shares 110,280 (+268.3%)

GEODE CAPITAL MANAGEMENT, LLC

Value ($000) $23,134 (+50.5%) Shares 851,908 (+4.3%)

MORGAN STANLEY

Value ($000) $3,314 (+101.3%) Shares 122,068 (+39.5%)

BANK OF AMERICA CORP /DE/

Value ($000) $2,345 (+124.8%) Shares 86,384 (+55.7%)

AMERICAN CENTURY COMPANIES INC

Value ($000) $2,383 (+77.1%) Shares 87,756 (+22.7%)

CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM

Value ($000) $398 (+871.9%) Shares 14,652 (+573.3%)

WELLS FARGO & COMPANY/MN

Value ($000) $999 (+111.1%) Shares 36,794 (+46.2%)

Institution	Prev Shares	Curr Shares	Change
Integral Health Asset Management, LLC	575,000	750,000	+175,000 (+30.4%)
Exome Asset Management LLC	51,960	64,845	+12,885 (+24.8%)
Woodline Partners LP	602,252	760,252	+158,000 (+26.2%)
UBS Group AG	272,271	1,806,243	+1,533,972 (+563.4%)
NORGES BANK	969,916	2,882,647	+1,912,731 (+197.2%)
MILLENNIUM MANAGEMENT LLC	40,113	517,264	+477,151 (+1189.5%)
BlackRock, Inc.	2,603,706	3,344,504	+740,798 (+28.5%)
STATE STREET CORP	1,114,581	1,319,226	+204,645 (+18.4%)
Invesco Ltd.	17,190	163,186	+145,996 (+849.3%)
DEUTSCHE BANK AG\	26,737	127,815	+101,078 (+378.0%)
GOLDMAN SACHS GROUP INC	223,214	333,481	+110,267 (+49.4%)
SummitTX Capital, L.P.	112,404	116,724	+4,320 (+3.8%)
ALPS ADVISORS INC	25,962	44,376	+18,414 (+70.9%)
JPMORGAN CHASE & CO	29,947	110,280	+80,333 (+268.3%)
GEODE CAPITAL MANAGEMENT, LLC	817,109	851,908	+34,799 (+4.3%)
MORGAN STANLEY	87,535	122,068	+34,533 (+39.5%)
BANK OF AMERICA CORP /DE/	55,473	86,384	+30,911 (+55.7%)
AMERICAN CENTURY COMPANIES INC	71,540	87,756	+16,216 (+22.7%)
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM	2,176	14,652	+12,476 (+573.3%)
WELLS FARGO & COMPANY/MN	25,160	36,794	+11,634 (+46.2%)

Decreased Positions (32)

Bain Capital Life Sciences Investors, LLC

Value ($000) $36,097 (-21.3%) Shares 1,329,544 (-45.5%)

TCG Crossover Management, LLC

Value ($000) $20,197 (-49.3%) Shares 743,886 (-64.9%)

Decheng Capital LLC

Value ($000) $85,335 (+38.1%) Shares 3,143,078 (-4.3%)

Omega Fund Management, LLC

Value ($000) $36,009 (+41.1%) Shares 1,326,293 (-2.2%)

Samsara BioCapital, LLC

Value ($000) $19,984 (+10.4%) Shares 736,047 (-23.5%)

Parkman Healthcare Partners LLC

Value ($000) $22,658 (+42.8%) Shares 834,559 (-1.1%)

Siren, L.L.C.

Value ($000) $15,976 (+7.7%) Shares 588,450 (-25.4%)

Nantahala Capital Management, LLC

Value ($000) $13,438 (+20.1%) Shares 494,971 (-16.8%)

Altshuler Shaham Ltd

Value ($000) $36,423 (+36.7%) Shares 1,341,540 (-5.3%)

MARSHALL WACE, LLP

Value ($000) $9,334 (-42.8%) Shares 343,791 (-60.4%)

Schonfeld Strategic Advisors LLC

Value ($000) $3,144 (-12.1%) Shares 115,807 (-39.1%)

FMR LLC

Value ($000) $204,119 (+34.2%) Shares 7,518,202 (-7.0%)

WELLINGTON MANAGEMENT GROUP LLP

Value ($000) $24,292 (+14.8%) Shares 894,733 (-20.5%)

Verition Fund Management LLC

Value ($000) $326 (-63.1%) Shares 12,020 (-74.4%)

Aster Capital Management (DIFC) Ltd

Value ($000) $7 (-65.7%) Shares 271 (-76.2%)

VANGUARD GROUP INC

Value ($000) $64,846 (+41.1%) Shares 2,388,439 (-2.2%)

CITIGROUP INC

Value ($000) $189 (-76.1%) Shares 6,949 (-83.5%)

NORTHERN TRUST CORP

Value ($000) $6,429 (+34.2%) Shares 236,799 (-7.0%)

RHUMBLINE ADVISERS

Value ($000) $1,127 (+21.3%) Shares 41,523 (-16.0%)

Bank of New York Mellon Corp

Value ($000) $2,304 (+33.8%) Shares 84,853 (-7.3%)

Institution	Prev Shares	Curr Shares	Change
Bain Capital Life Sciences Investors, LLC	2,439,538	1,329,544	-1,109,994 (-45.5%)
TCG Crossover Management, LLC	2,117,103	743,886	-1,373,217 (-64.9%)
Decheng Capital LLC	3,285,293	3,143,078	-142,215 (-4.3%)
Omega Fund Management, LLC	1,356,293	1,326,293	-30,000 (-2.2%)
Samsara BioCapital, LLC	962,154	736,047	-226,107 (-23.5%)
Parkman Healthcare Partners LLC	843,502	834,559	-8,943 (-1.1%)
Siren, L.L.C.	788,450	588,450	-200,000 (-25.4%)
Nantahala Capital Management, LLC	594,971	494,971	-100,000 (-16.8%)
Altshuler Shaham Ltd	1,416,822	1,341,540	-75,282 (-5.3%)
MARSHALL WACE, LLP	867,999	343,791	-524,208 (-60.4%)
Schonfeld Strategic Advisors LLC	190,244	115,807	-74,437 (-39.1%)
FMR LLC	8,086,413	7,518,202	-568,211 (-7.0%)
WELLINGTON MANAGEMENT GROUP LLP	1,125,395	894,733	-230,662 (-20.5%)
Verition Fund Management LLC	47,001	12,020	-34,981 (-74.4%)
Aster Capital Management (DIFC) Ltd	1,141	271	-870 (-76.2%)
VANGUARD GROUP INC	2,442,551	2,388,439	-54,112 (-2.2%)
CITIGROUP INC	42,037	6,949	-35,088 (-83.5%)
NORTHERN TRUST CORP	254,719	236,799	-17,920 (-7.0%)
RHUMBLINE ADVISERS	49,406	41,523	-7,883 (-16.0%)
Bank of New York Mellon Corp	91,521	84,853	-6,668 (-7.3%)

Exited Positions (8)

Ikarian Capital, LLC

Value ($000) $3,031 Shares 161,113

BOOTHBAY FUND MANAGEMENT, LLC

Value ($000) $1,153 Shares 61,299

BALYASNY ASSET MANAGEMENT L.P.

Value ($000) $1,376 Shares 73,131

Caption Management, LLC

Value ($000) $342 Shares 18,196

NOMURA HOLDINGS INC

Value ($000) $532 Shares 28,290

GROUP ONE TRADING, L.P.

Value ($000) $25 Shares 1,305

Clearstead Advisors, LLC

Value ($000) $3 Shares 163

COMMONWEALTH EQUITY SERVICES, LLC

Value ($000) $0 Shares 15,503

Institution	Prev Shares	Prev Value ($000)
Ikarian Capital, LLC	161,113	$3,031
BOOTHBAY FUND MANAGEMENT, LLC	61,299	$1,153
BALYASNY ASSET MANAGEMENT L.P.	73,131	$1,376
Caption Management, LLC	18,196	$342
NOMURA HOLDINGS INC	28,290	$532
GROUP ONE TRADING, L.P.	1,305	$25
Clearstead Advisors, LLC	163	$3
COMMONWEALTH EQUITY SERVICES, LLC	15,503	$0