| ARK Investment Management LLC | 12,467,189 | $345,590 |
| FMR LLC | 11,909,138 | $330,121 |
| FARALLON CAPITAL MANAGEMENT LLC | 10,063,111 | $278,949 |
| VANGUARD GROUP INC | 9,193,474 | $254,843 |
| BlackRock, Inc. | 8,450,182 | $234,239 |
| STATE STREET CORP | 5,228,529 | $144,935 |
| ARCH Venture Management, LLC | 4,540,132 | $125,852 |
| Sumitomo Mitsui Trust Holdings, Inc. | 4,409,300 | $122,226 |
| Nikko Asset Management Americas, Inc. | 4,409,300 | $122,182 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,730,282 | $76 |
| Kynam Capital Management, LP | 2,440,214 | $67,643 |
| GEODE CAPITAL MANAGEMENT, LLC | 2,351,908 | $65,206 |
| DIMENSIONAL FUND ADVISORS LP | 1,947,879 | $53,996 |
| UBS ASSET MANAGEMENT AMERICAS INC | 1,712,359 | $47,467 |
| Casdin Capital, LLC | 1,600,000 | $44,352 |
| Redmile Group, LLC | 1,285,859 | $35,644 |
| MWG Caph Ltd | 1,266,934 | $35,119 |
| TWO SIGMA INVESTMENTS, LP | 1,120,389 | $31,057 |
| Woodline Partners LP | 993,066 | $27,528 |
| UBS Group AG | 973,843 | $26,995 |
| MARSHALL WACE, LLP | 945,829 | $26,218 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 834,795 | $23,141 |
| NORTHERN TRUST CORP | 808,947 | $22,424 |
| MORGAN STANLEY | 729,400 | $20,219 |
| JPMORGAN CHASE & CO | 619,241 | $17,165 |
| RTW INVESTMENTS, LP | 570,394 | $15,811 |
| Integral Health Asset Management, LLC | 550,000 | $15,246 |
| IQ EQ FUND MANAGEMENT (IRELAND) Ltd | 533,563 | $14,790 |
| TWO SIGMA ADVISERS, LP | 527,802 | $14,631 |
| GOLDMAN SACHS GROUP INC | 522,636 | $14,487 |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 492,430 | $13,650 |
| Elmind Capital, LP | 476,338 | $13,204 |
| BNP PARIBAS ARBITRAGE, SA | 468,910 | $12,998 |
| BANK OF AMERICA CORP /DE/ | 427,328 | $11,846 |
| BAILLIE GIFFORD & CO | 416,224 | $11,538 |
| Qube Research & Technologies Ltd | 399,659 | $11,079 |
| Bank of New York Mellon Corp | 357,671 | $9,915 |
| BARCLAYS PLC | 326,178 | $9,042 |
| Pictet Asset Management Holding SA | 325,654 | $9,064 |
| Alphabet Inc. | 321,604 | $8,915 |
| MILLENNIUM MANAGEMENT LLC | 301,650 | $8,362 |
| PEREGRINE INVESTMENT MANAGEMENT INC | 257,280 | $7,132 |
| CITADEL ADVISORS LLC | 255,710 | $7,088 |
| Nuveen, LLC | 233,065 | $6,461 |
| Invesco Ltd. | 213,185 | $5,909 |
| Vestmark Advisory Solutions, Inc. | 196,036 | $5,434 |
| TD Asset Management Inc | 191,248 | $5,301 |
| Swiss National Bank | 179,500 | $4,976 |
| Caption Management, LLC | 178,352 | $4,944 |
| Rafferty Asset Management, LLC | 176,859 | $4,903 |
| Liontrust Investment Partners LLP | 170,404 | $4,724 |
| ExodusPoint Capital Management, LP | 163,316 | $4,527 |
| WELLS FARGO & COMPANY/MN | 159,188 | $4,413 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 157,030 | $4,364 |
| RENAISSANCE TECHNOLOGIES LLC | 156,500 | $4,338 |
| HRT FINANCIAL LP | 151,183 | $4 |
| AMERICAN CENTURY COMPANIES INC | 148,303 | $4,111 |
| Susquehanna Portfolio Strategies, LLC | 138,132 | $3,829 |
| SummitTX Capital, L.P. | 137,946 | $3,824 |
| RHUMBLINE ADVISERS | 131,199 | $3,637 |
| Schonfeld Strategic Advisors LLC | 128,360 | $3,558 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 112,771 | $3,127 |
| Bellevue Group AG | 111,510 | $3,091 |
| SG Americas Securities, LLC | 103,469 | $3 |
| ALLIANCEBERNSTEIN L.P. | 100,720 | $2,792 |
| D.A. DAVIDSON & CO. | 98,883 | $2,741 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 98,511 | $2,731 |
| Legal & General Group Plc | 92,078 | $2,552 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 87,265 | $2,419 |
| DEUTSCHE BANK AG\ | 77,564 | $2,150 |
| Concurrent Investment Advisors, LLC | 76,825 | $2,130 |
| Privium Fund Management B.V. | 71,500 | $1,982 |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 69,964 | $1,945 |
| PROFUND ADVISORS LLC | 65,617 | $1,819 |
| FIRST TRUST ADVISORS LP | 64,056 | $1,776 |
| BOOTHBAY FUND MANAGEMENT, LLC | 60,759 | $1,684 |
| Clarius Group, LLC | 60,615 | $1,680 |
| STATE OF WISCONSIN INVESTMENT BOARD | 58,526 | $1,622 |
| Voya Investment Management LLC | 56,091 | $1,555 |
| LPL Financial LLC | 55,619 | $1,542 |
| MetLife Investment Management, LLC | 54,523 | $1,511 |
| DekaBank Deutsche Girozentrale | 50,000 | $2 |
| Ishara Investments LP | 50,000 | $1,386 |
| Generali Investments Towarzystwo Funduszy Inwestycyjnych | 45,000 | $1,247 |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 43,781 | $1,214 |
| Raiffeisen Bank International AG | 43,000 | $1,196 |
| WCG Wealth Advisors LLC | 39,917 | $1,106 |
| VIRGINIA RETIREMENT SYSTEMS ET AL | 39,531 | $1,096 |
| JANUS HENDERSON GROUP PLC | 39,501 | $1,095 |
| INTECH INVESTMENT MANAGEMENT LLC | 38,053 | $1,055 |
| WELLINGTON MANAGEMENT GROUP LLP | 36,902 | $1,023 |
| BENJAMIN EDWARDS INC | 35,802 | $992 |
| ALGERT GLOBAL LLC | 34,290 | $1 |
| Handelsbanken Fonder AB | 33,623 | $1 |
| BALYASNY ASSET MANAGEMENT L.P. | 32,711 | $907 |
| ENVESTNET ASSET MANAGEMENT INC | 31,532 | $874 |
| State of New Jersey Common Pension Fund D | 31,076 | $861 |
| VICTORY CAPITAL MANAGEMENT INC | 30,982 | $859 |
| NEW YORK STATE COMMON RETIREMENT FUND | 30,629 | $849 |
| GUGGENHEIM CAPITAL LLC | 29,508 | $818 |
| 141 other institutions | 935,306 | $24,696 |