| BlackRock, Inc. | 5,170,766 | $2,519,456 |
| VANGUARD GROUP INC | 4,176,016 | $2,034,764 |
| Avoro Capital Advisors LLC | 2,606,060 | $1,269,803 |
| WELLINGTON MANAGEMENT GROUP LLP | 2,441,492 | $1,189,617 |
| RENAISSANCE TECHNOLOGIES LLC | 1,909,259 | $930,286 |
| STATE STREET CORP | 1,842,411 | $897,715 |
| AQR CAPITAL MANAGEMENT LLC | 1,281,699 | $624,508 |
| GEODE CAPITAL MANAGEMENT, LLC | 1,193,064 | $580,238 |
| JANUS HENDERSON GROUP PLC | 796,101 | $387,801 |
| ASSETMARK, INC | 634,956 | $309,382 |
| Invesco Ltd. | 608,759 | $296,618 |
| NORGES BANK | 602,191 | $293,418 |
| DIMENSIONAL FUND ADVISORS LP | 528,210 | $257,405 |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 425,993 | $207,565 |
| NORTHERN TRUST CORP | 418,427 | $203,879 |
| LSV ASSET MANAGEMENT | 408,065 | $199 |
| FMR LLC | 403,830 | $196,766 |
| MORGAN STANLEY | 389,275 | $189,675 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 352,086 | $172 |
| Bank of New York Mellon Corp | 333,629 | $162,561 |
| Swedbank AB | 324,772 | $158,245 |
| BAILLIE GIFFORD & CO | 323,016 | $157,390 |
| D. E. Shaw & Co., Inc. | 306,971 | $149,572 |
| Pictet Asset Management Holding SA | 306,837 | $149,669 |
| CAISSE DE DEPOT ET PLACEMENT DU QUEBEC | 296,320 | $144,382 |
| FULLER & THALER ASSET MANAGEMENT, INC. | 290,613 | $141,601 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 289,926 | $141,266 |
| JPMORGAN CHASE & CO | 262,215 | $127,764 |
| LORD, ABBETT & CO. LLC | 258,049 | $126 |
| Eversept Partners, LP | 252,592 | $123,075 |
| Nuveen, LLC | 251,809 | $122,694 |
| Pacer Advisors, Inc. | 241,872 | $117,852 |
| VICTORY CAPITAL MANAGEMENT INC | 228,383 | $111,280 |
| UBS Group AG | 225,849 | $110,045 |
| FIRST TRUST ADVISORS LP | 219,023 | $106,719 |
| JANE STREET GROUP, LLC | 216,820 | $105,646 |
| ALLIANCEBERNSTEIN L.P. | 206,543 | $100,638 |
| BANK OF AMERICA CORP /DE/ | 205,131 | $99,950 |
| UBS ASSET MANAGEMENT AMERICAS INC | 203,351 | $99,083 |
| ACADIAN ASSET MANAGEMENT LLC | 200,531 | $98 |
| CITADEL ADVISORS LLC | 187,164 | $91,196 |
| Point72 Asset Management, L.P. | 186,164 | $90,708 |
| CITIGROUP INC | 184,408 | $89,853 |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 181,177 | $88,279 |
| FRANKLIN RESOURCES INC | 181,120 | $88,251 |
| Legal & General Group Plc | 173,592 | $84,583 |
| Amundi | 163,194 | $79,516 |
| COMERICA BANK | 161,683 | $78,780 |
| Sofinnova Investments, Inc. | 157,641 | $76,811 |
| SEIZERT CAPITAL PARTNERS, LLC | 145,522 | $70,906 |
| HSBC HOLDINGS PLC | 143,624 | $70,053 |
| Epoch Investment Partners, Inc. | 142,292 | $69,332 |
| Seven Fleet Capital Management LP | 130,000 | $633 |
| Candriam S.C.A. | 127,215 | $61,988 |
| DEUTSCHE BANK AG\ | 124,475 | $60,650 |
| RHUMBLINE ADVISERS | 121,751 | $59,323 |
| Tri Locum Partners LP | 120,921 | $58,919 |
| Thrivent Financial for Lutherans | 120,802 | $59 |
| Swiss National Bank | 117,735 | $57,366 |
| Robeco Institutional Asset Management B.V. | 113,850 | $55,473 |
| TD Asset Management Inc | 113,135 | $55,125 |
| GOLDMAN SACHS GROUP INC | 110,774 | $53,975 |
| ORBIMED ADVISORS LLC | 105,200 | $51,259 |
| Allspring Global Investments Holdings, LLC | 104,785 | $52,049 |
| Polaris Capital Management, LLC | 103,650 | $50,503 |
| AMERIPRISE FINANCIAL INC | 101,042 | $49,231 |
| Qube Research & Technologies Ltd | 98,304 | $47,899 |
| PRINCIPAL FINANCIAL GROUP INC | 98,158 | $47,827 |
| Retirement Systems of Alabama | 97,268 | $47,394 |
| DekaBank Deutsche Girozentrale | 93,532 | $24 |
| Sumitomo Mitsui Trust Holdings, Inc. | 92,156 | $44,903 |
| Krensavage Asset Management, LLC | 91,282 | $44 |
| WELLS FARGO & COMPANY/MN | 90,940 | $44,310 |
| BARCLAYS PLC | 90,925 | $44,303 |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 83,356 | $40,615 |
| Gotham Asset Management, LLC | 80,018 | $38,989 |
| Man Group plc | 79,002 | $38,494 |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 69,367 | $33,799 |
| AMERICAN CENTURY COMPANIES INC | 67,957 | $33,112 |
| PFM Health Sciences, LP | 67,743 | $33,008 |
| Bridgewater Associates, LP | 64,595 | $31,474 |
| BNP Paribas Investment Partners S.A. | 64,537 | $31 |
| MILLENNIUM MANAGEMENT LLC | 64,073 | $31,220 |
| First Turn Management, LLC | 63,580 | $30,979 |
| ATWOOD & PALMER INC | 63,532 | $30,956 |
| HRT FINANCIAL LP | 63,397 | $31 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 63,304 | $30,845 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 61,700 | $30,334 |
| TOCQUEVILLE ASSET MANAGEMENT L.P. | 61,143 | $29,792 |
| WEDGE CAPITAL MANAGEMENT L L P/NC | 60,687 | $29,570 |
| Soleus Capital Management, L.P. | 60,000 | $29,235 |
| IEQ CAPITAL, LLC | 58,959 | $28,728 |
| Palo Alto Investors LP | 58,186 | $28,351 |
| ROYAL BANK OF CANADA | 57,288 | $27,914 |
| Summit Street Capital Management, LLC | 56,872 | $27,711 |
| BALYASNY ASSET MANAGEMENT L.P. | 55,934 | $27,254 |
| Caption Management, LLC | 55,081 | $26,838 |
| Russell Investments Group, Ltd. | 54,811 | $26,838 |
| Corient Private Wealth LLC | 53,771 | $8,430 |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 52,012 | $25,343 |
| 720 other institutions | 4,055,776 | $1,739,431 |