| VANGUARD GROUP INC | 16,719,886 | $1,331,739 |
| FARALLON CAPITAL MANAGEMENT LLC | 14,582,796 | $1,161,520 |
| JANUS HENDERSON GROUP PLC | 12,303,502 | $980,036 |
| BAKER BROS. ADVISORS LP | 9,455,357 | $753,119 |
| BlackRock, Inc. | 8,926,656 | $711,008 |
| FMR LLC | 8,587,981 | $684,033 |
| Nextech Invest, Ltd. | 7,601,087 | $605,427 |
| WELLINGTON MANAGEMENT GROUP LLP | 6,987,639 | $556,565 |
| Paradigm Biocapital Advisors LP | 6,644,403 | $529,227 |
| Bellevue Group AG | 5,005,719 | $398,706 |
| STATE STREET CORP | 4,109,290 | $327,305 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,404,717 | $271 |
| BVF INC/IL | 3,356,782 | $267,368 |
| Alphabet Inc. | 3,345,102 | $266,437 |
| GEODE CAPITAL MANAGEMENT, LLC | 3,161,963 | $251,912 |
| UBS Group AG | 3,087,937 | $245,954 |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 2,894,613 | $230,556 |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 2,845,013 | $226,605 |
| GENERAL ATLANTIC, L.P. | 2,812,928 | $224,050 |
| Casdin Capital, LLC | 2,577,333 | $205,285 |
| Woodline Partners LP | 2,500,895 | $199,196 |
| GOLDMAN SACHS GROUP INC | 2,491,583 | $198,455 |
| NORGES BANK | 2,455,347 | $195,568 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,205,555 | $175,672 |
| Lunate Capital Ltd | 2,196,200 | $174,927 |
| Avoro Capital Advisors LLC | 2,170,000 | $172,841 |
| AMERIPRISE FINANCIAL INC | 2,056,857 | $163,829 |
| Polar Capital Holdings Plc | 2,013,791 | $160,398 |
| Logos Global Management LP | 2,000,000 | $159,300 |
| Holocene Advisors, LP | 1,907,948 | $151,968 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,683,729 | $134,109 |
| D. E. Shaw & Co., Inc. | 1,613,730 | $128,534 |
| Rock Springs Capital Management LP | 1,335,270 | $106,354 |
| Siren, L.L.C. | 1,335,075 | $106,339 |
| CITADEL ADVISORS LLC | 1,302,361 | $103,733 |
| T. Rowe Price Investment Management, Inc. | 1,300,257 | $104 |
| Caligan Partners LP | 1,283,900 | $102,263 |
| Integral Health Asset Management, LLC | 1,200,000 | $95,580 |
| DIMENSIONAL FUND ADVISORS LP | 1,161,646 | $92,525 |
| Jefferies Financial Group Inc. | 1,141,195 | $90,896 |
| Pictet Asset Management Holding SA | 1,137,121 | $90,654 |
| JANE STREET GROUP, LLC | 1,090,416 | $86,852 |
| FRANKLIN RESOURCES INC | 1,060,171 | $84,443 |
| Candriam S.C.A. | 1,030,992 | $82,122 |
| Hood River Capital Management LLC | 945,585 | $75,316 |
| a16z Capital Management, L.L.C. | 921,099 | $73,366 |
| AIHC Capital Management Ltd | 900,392 | $71,716 |
| BANK OF AMERICA CORP /DE/ | 879,845 | $70,080 |
| NORTHERN TRUST CORP | 850,323 | $67,728 |
| MILLENNIUM MANAGEMENT LLC | 800,118 | $63,729 |
| Frazier Life Sciences Management, L.P. | 797,455 | $63,517 |
| MORGAN STANLEY | 651,732 | $51,911 |
| First Turn Management, LLC | 638,385 | $50,847 |
| BNP PARIBAS ARBITRAGE, SA | 619,387 | $49,334 |
| DAFNA Capital Management LLC | 604,514 | $48,150 |
| Bank of New York Mellon Corp | 542,069 | $43,176 |
| MIC Capital Management UK LLP | 508,569 | $40,508 |
| MPM BioImpact LLC | 505,672 | $40,277 |
| ROYAL BANK OF CANADA | 503,721 | $40,121 |
| AMERICAN CENTURY COMPANIES INC | 467,360 | $37,225 |
| Point72 Asset Management, L.P. | 446,616 | $35,573 |
| TCG Crossover Management, LLC | 436,473 | $34,765 |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 430,768 | $34,311 |
| TWO SIGMA INVESTMENTS, LP | 421,735 | $33,591 |
| JPMORGAN CHASE & CO | 421,627 | $33,583 |
| BALYASNY ASSET MANAGEMENT L.P. | 415,207 | $33,071 |
| Nuveen, LLC | 406,241 | $32,357 |
| Boxer Capital Management, LLC | 400,000 | $31,860 |
| LORD, ABBETT & CO. LLC | 399,484 | $32 |
| MARSHALL WACE, LLP | 386,191 | $30,760 |
| EVENTIDE ASSET MANAGEMENT, LLC | 378,261 | $30,129 |
| TD Asset Management Inc | 370,520 | $29,512 |
| Checkpoint Capital L.P. | 370,000 | $29,471 |
| Invesco Ltd. | 367,851 | $29,299 |
| Defilade Capital Management, L.P. | 363,454 | $28,949 |
| UBS ASSET MANAGEMENT AMERICAS INC | 349,412 | $27,831 |
| Mass General Brigham, Inc | 344,091 | $27,407 |
| BOOTHBAY FUND MANAGEMENT, LLC | 327,152 | $26,058 |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 322,289 | $25,670 |
| Nicholas Investment Partners, LP | 317,711 | $25,306 |
| JENNISON ASSOCIATES LLC | 305,260 | $24,314 |
| Vestal Point Capital, LP | 295,000 | $23,497 |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 291,006 | $23,179 |
| TWO SIGMA ADVISERS, LP | 287,646 | $22,911 |
| Swiss National Bank | 276,331 | $22,010 |
| RAYMOND JAMES FINANCIAL INC | 244,174 | $19,450 |
| Fisher Asset Management, LLC | 241,057 | $19,200 |
| Alyeska Investment Group, L.P. | 239,097 | $19,044 |
| Ensign Peak Advisors, Inc | 235,808 | $18,782 |
| Catalyst Funds Management Pty Ltd | 223,569 | $17,807 |
| MARSICO CAPITAL MANAGEMENT LLC | 219,460 | $17,480 |
| Decheng Capital LLC | 200,000 | $15,930 |
| BAILLIE GIFFORD & CO | 194,959 | $15,528 |
| Verition Fund Management LLC | 189,333 | $15,080 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 183,221 | $14,594 |
| a16z Perennial Management, L.P. | 182,918 | $14,569 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 171,543 | $13,666 |
| RHUMBLINE ADVISERS | 160,448 | $12,780 |
| Legal & General Group Plc | 153,380 | $12,217 |
| PFM Health Sciences, LP | 151,453 | $12,063 |
| 284 other institutions | 7,016,600 | $509,989 |