| FMR LLC | 13,149,960 | $454,594 |
| BlackRock, Inc. | 8,209,392 | $283,799 |
| JANUS HENDERSON GROUP PLC | 7,186,456 | $248,344 |
| Capital Research Global Investors | 5,279,675 | $182,518 |
| VANGUARD GROUP INC | 5,019,324 | $173,518 |
| STATE STREET CORP | 4,134,641 | $142,935 |
| BAKER BROS. ADVISORS LP | 3,618,826 | $125,103 |
| FEDERATED HERMES, INC. | 3,395,771 | $117,392 |
| Logos Global Management LP | 3,125,000 | $108,031 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,800,000 | $96,796 |
| Fiera Capital Corp | 2,437,262 | $84,256 |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 2,153,043 | $74,431 |
| GEODE CAPITAL MANAGEMENT, LLC | 2,073,583 | $71,695 |
| Point72 Asset Management, L.P. | 1,844,556 | $63,766 |
| GOLDMAN SACHS GROUP INC | 1,770,866 | $61,219 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,449,145 | $50 |
| GSK plc | 1,333,333 | $46,093 |
| MORGAN STANLEY | 1,252,404 | $43,296 |
| UBS Group AG | 1,085,632 | $37,530 |
| Candriam S.C.A. | 1,031,354 | $35,655 |
| Ensign Peak Advisors, Inc | 979,063 | $33,846 |
| CITADEL ADVISORS LLC | 959,355 | $33,165 |
| DIMENSIONAL FUND ADVISORS LP | 938,857 | $32,456 |
| BANK OF AMERICA CORP /DE/ | 902,973 | $31,216 |
| Fisher Asset Management, LLC | 889,633 | $30,755 |
| Sofinnova Investments, Inc. | 885,121 | $30,599 |
| Redmile Group, LLC | 742,017 | $25,652 |
| Pictet Asset Management Holding SA | 734,335 | $25,386 |
| First Turn Management, LLC | 723,653 | $25,017 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 714,633 | $24,705 |
| BNP Paribas Investment Partners S.A. | 697,925 | $24 |
| NORTHERN TRUST CORP | 675,123 | $23,339 |
| BALYASNY ASSET MANAGEMENT L.P. | 596,483 | $20,620 |
| abrdn plc | 560,623 | $19,381 |
| NEW YORK STATE COMMON RETIREMENT FUND | 508,347 | $17,574 |
| DAFNA Capital Management LLC | 506,740 | $17,518 |
| Qube Research & Technologies Ltd | 467,851 | $16,174 |
| Iron Triangle Partners LP | 467,484 | $16,161 |
| TANG CAPITAL MANAGEMENT LLC | 450,000 | $15,557 |
| Nuveen, LLC | 374,007 | $12,929 |
| DEUTSCHE BANK AG\ | 368,481 | $12,738 |
| JPMORGAN CHASE & CO | 299,888 | $10,367 |
| EVENTIDE ASSET MANAGEMENT, LLC | 284,069 | $9,820 |
| GENERAL AMERICAN INVESTORS CO INC | 280,261 | $9,689 |
| ENVESTNET ASSET MANAGEMENT INC | 277,560 | $9,595 |
| WELLS FARGO & COMPANY/MN | 256,144 | $8,855 |
| Rhenman & Partners Asset Management AB | 250,000 | $8,643 |
| Bank of New York Mellon Corp | 244,041 | $8,436 |
| FRANKLIN RESOURCES INC | 240,209 | $8,304 |
| Invesco Ltd. | 238,314 | $8,239 |
| BARCLAYS PLC | 235,872 | $8,154 |
| WCM INVESTMENT MANAGEMENT, LLC | 219,268 | $7,567 |
| MILLENNIUM MANAGEMENT LLC | 208,548 | $7,210 |
| AMERICAN CENTURY COMPANIES INC | 204,398 | $7,066 |
| Susquehanna Portfolio Strategies, LLC | 202,434 | $6,998 |
| Woodline Partners LP | 201,667 | $6,972 |
| Nicholas Investment Partners, LP | 192,413 | $6,652 |
| Alyeska Investment Group, L.P. | 192,308 | $6,648 |
| UBS ASSET MANAGEMENT AMERICAS INC | 174,124 | $6,019 |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 171,278 | $5,911 |
| ROYAL BANK OF CANADA | 165,323 | $5,715 |
| VICTORY CAPITAL MANAGEMENT INC | 163,407 | $5,649 |
| STEMPOINT CAPITAL LP | 161,659 | $5,589 |
| Swiss National Bank | 155,600 | $5,379 |
| GREAT LAKES ADVISORS, LLC | 149,993 | $5,185 |
| Creative Planning | 136,055 | $4,703 |
| CITIGROUP INC | 127,067 | $4,393 |
| Rafferty Asset Management, LLC | 126,362 | $4,368 |
| PLATINUM INVESTMENT MANAGEMENT LTD | 120,604 | $4,169 |
| TWO SIGMA INVESTMENTS, LP | 113,841 | $3,935 |
| FIDEURAM - INTESA SANPAOLO PRIVATE BANKING S.P.A. | 113,451 | $3,922 |
| NEUBERGER BERMAN GROUP LLC | 111,276 | $3,847 |
| RHUMBLINE ADVISERS | 107,625 | $3,721 |
| ALLIANCEBERNSTEIN L.P. | 97,886 | $3,384 |
| HealthInvest Partners AB | 97,438 | $3,368 |
| MML INVESTORS SERVICES, LLC | 83,939 | $2,902 |
| Legal & General Group Plc | 83,865 | $2,899 |
| Y-Intercept (Hong Kong) Ltd | 81,033 | $2,801 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 75,945 | $2,625 |
| Sio Capital Management, LLC | 75,730 | $2,618 |
| ASSETMARK, INC | 71,937 | $2,487 |
| ALPS ADVISORS INC | 71,789 | $2,482 |
| NEOS Investment Management LLC | 71,178 | $2,461 |
| TEMA ETFS LLC | 70,128 | $2,424 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 69,909 | $2,415 |
| SEI INVESTMENTS CO | 68,707 | $2,375 |
| AQR CAPITAL MANAGEMENT LLC | 68,177 | $2,357 |
| XTX Topco Ltd | 66,175 | $2,288 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 63,558 | $2,197 |
| BOOTHBAY FUND MANAGEMENT, LLC | 60,258 | $2,083 |
| Brinker Capital Investments, LLC | 58,394 | $2,019 |
| Caption Management, LLC | 57,167 | $1,976 |
| Lido Advisors, LLC | 55,465 | $1,913 |
| DekaBank Deutsche Girozentrale | 50,000 | $2 |
| Connor, Clark & Lunn Investment Management Ltd. | 48,920 | $1,691 |
| TUDOR INVESTMENT CORP ET AL | 47,938 | $1,657 |
| PROFUND ADVISORS LLC | 47,115 | $1,629 |
| TD Asset Management Inc | 46,040 | $1,592 |
| Cinctive Capital Management LP | 45,965 | $1,589 |
| MetLife Investment Management, LLC | 45,813 | $1,584 |
| 143 other institutions | 1,495,177 | $47,794 |