| BlackRock, Inc. | 28,949,515 | $164,144 |
| VANGUARD GROUP INC | 17,880,873 | $101,385 |
| STATE STREET CORP | 14,623,269 | $82,914 |
| Rubric Capital Management LP | 7,476,495 | $42,392 |
| GEODE CAPITAL MANAGEMENT, LLC | 7,374,138 | $41,819 |
| Nitorum Capital, L.P. | 5,325,823 | $30,197 |
| UBS Group AG | 5,103,097 | $28,935 |
| Avoro Capital Advisors LLC | 4,444,444 | $25,200 |
| MORGAN STANLEY | 4,443,922 | $25,197 |
| DIMENSIONAL FUND ADVISORS LP | 4,443,603 | $25,195 |
| Frazier Life Sciences Management, L.P. | 4,225,000 | $23,956 |
| FMR LLC | 3,577,534 | $20,285 |
| CITADEL ADVISORS LLC | 3,571,955 | $20,253 |
| WELLINGTON MANAGEMENT GROUP LLP | 3,305,012 | $18,739 |
| TSP Capital Management Group, LLC | 2,963,175 | $16,801 |
| 180 WEALTH ADVISORS, LLC | 2,958,944 | $16,777 |
| NORTHERN TRUST CORP | 2,629,888 | $14,911 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 2,564,526 | $14,541 |
| BANK OF AMERICA CORP /DE/ | 2,362,221 | $13,394 |
| Nuveen, LLC | 2,162,242 | $12,260 |
| GOLDMAN SACHS GROUP INC | 1,921,967 | $10,898 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,894,000 | $10,739 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,882,234 | $10,672 |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 1,861,046 | $10,552 |
| Eversept Partners, LP | 1,852,563 | $10,504 |
| Qube Research & Technologies Ltd | 1,831,136 | $10,383 |
| RENAISSANCE TECHNOLOGIES LLC | 1,757,487 | $9,965 |
| EcoR1 Capital, LLC | 1,660,000 | $9,412 |
| Invesco Ltd. | 1,580,796 | $8,963 |
| WELLS FARGO & COMPANY/MN | 1,248,545 | $7,079 |
| APIS CAPITAL ADVISORS, LLC | 1,200,100 | $6,805 |
| TWO SIGMA INVESTMENTS, LP | 1,188,438 | $6,738 |
| UBS ASSET MANAGEMENT AMERICAS INC | 1,089,059 | $6,175 |
| AXIOM INVESTORS LLC /DE | 1,037,704 | $5,884 |
| BARCLAYS PLC | 1,025,437 | $5,814 |
| DELTEC ASSET MANAGEMENT LLC | 974,700 | $5,527 |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 894,204 | $5,070 |
| Bank of New York Mellon Corp | 873,493 | $4,953 |
| DEUTSCHE BANK AG\ | 843,026 | $4,780 |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 827,853 | $4,686 |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 707,140 | $4,009 |
| SCOPIA CAPITAL MANAGEMENT LP | 694,961 | $3,940 |
| Apollo Management Holdings, L.P. | 664,113 | $3,766 |
| Parkman Healthcare Partners LLC | 640,356 | $3,631 |
| AQR CAPITAL MANAGEMENT LLC | 639,249 | $3,625 |
| FIRST TRUST ADVISORS LP | 587,186 | $3,329 |
| Russell Investments Group, Ltd. | 578,402 | $3,280 |
| Swiss National Bank | 574,700 | $3,259 |
| D. E. Shaw & Co., Inc. | 553,759 | $3,140 |
| JANE STREET GROUP, LLC | 548,257 | $3,109 |
| 1492 Capital Management LLC | 535,270 | $3,035 |
| JPMORGAN CHASE & CO | 522,190 | $2,961 |
| MILLENNIUM MANAGEMENT LLC | 512,740 | $2,907 |
| TWO SIGMA ADVISERS, LP | 510,964 | $2,897 |
| Schonfeld Strategic Advisors LLC | 484,162 | $2,745 |
| SEI INVESTMENTS CO | 472,859 | $2,681 |
| Rafferty Asset Management, LLC | 452,470 | $2,566 |
| Trexquant Investment LP | 446,930 | $2,534 |
| BNP PARIBAS ARBITRAGE, SA | 432,785 | $2,454 |
| Squarepoint Ops LLC | 427,058 | $2,421 |
| VICTORY CAPITAL MANAGEMENT INC | 405,660 | $2,300 |
| RHUMBLINE ADVISERS | 381,423 | $2,163 |
| RAYMOND JAMES FINANCIAL INC | 375,561 | $2,129 |
| Calamos Advisors LLC | 370,718 | $2,102 |
| PRINCIPAL FINANCIAL GROUP INC | 333,829 | $1,893 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 307,158 | $2 |
| DIADEMA PARTNERS LP | 302,000 | $1,712 |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 300,504 | $1,704 |
| Legal & General Group Plc | 294,003 | $1,667 |
| ALLIANCEBERNSTEIN L.P. | 278,850 | $1,581 |
| Voleon Capital Management LP | 269,796 | $1,530 |
| MARSHALL WACE, LLP | 264,293 | $1,499 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 255,615 | $1,449 |
| ExodusPoint Capital Management, LP | 245,279 | $1,391 |
| Y-Intercept (Hong Kong) Ltd | 238,681 | $1,353 |
| Aquatic Capital Management LLC | 222,163 | $1,260 |
| Mariner, LLC | 209,479 | $1,188 |
| ROYAL BANK OF CANADA | 206,612 | $1,170 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 204,121 | $1,157 |
| Aaron Wealth Advisors LLC | 200,763 | $1,138 |
| Bruce & Co., Inc. | 195,073 | $1,106 |
| BALYASNY ASSET MANAGEMENT L.P. | 194,978 | $1,106 |
| Man Group plc | 178,494 | $1,012 |
| Creative Planning | 171,757 | $974 |
| PROFUND ADVISORS LLC | 169,001 | $958 |
| FRANKLIN RESOURCES INC | 163,280 | $926 |
| STATE OF WISCONSIN INVESTMENT BOARD | 161,951 | $918 |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 161,300 | $1 |
| MetLife Investment Management, LLC | 154,254 | $875 |
| SG Americas Securities, LLC | 143,592 | $1 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 140,440 | $796 |
| JANUS HENDERSON GROUP PLC | 127,763 | $724 |
| INTECH INVESTMENT MANAGEMENT LLC | 127,363 | $722 |
| Brevan Howard Capital Management LP | 122,610 | $695 |
| Walleye Capital LLC | 121,148 | $687 |
| ACADIAN ASSET MANAGEMENT LLC | 116,975 | $1 |
| SIMPLEX TRADING, LLC | 115,191 | $653 |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 106,440 | $591 |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 105,945 | $601 |
| HUB Investment Partners, LLC | 104,429 | $592 |
| 153 other institutions | 3,505,863 | $18,810 |