| BlackRock, Inc. | 3,550,848 | $327,495 |
| VANGUARD GROUP INC | 2,953,170 | $272,371 |
| WELLINGTON MANAGEMENT GROUP LLP | 2,211,091 | $203,929 |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 1,505,872 | $138,887 |
| MORGAN STANLEY | 1,259,762 | $116,188 |
| D. E. Shaw & Co., Inc. | 1,212,162 | $111,798 |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 1,161,285 | $107,105 |
| STATE STREET CORP | 918,504 | $84,714 |
| Artisan Partners Limited Partnership | 785,742 | $72,469 |
| FULLER & THALER ASSET MANAGEMENT, INC. | 668,099 | $61,619 |
| JANUS HENDERSON GROUP PLC | 562,331 | $51,861 |
| BRAIDWELL LP | 540,890 | $49,886 |
| MARSHALL WACE, LLP | 531,079 | $48,981 |
| DEUTSCHE BANK AG\ | 516,816 | $47,666 |
| CITADEL ADVISORS LLC | 511,318 | $47,159 |
| GEODE CAPITAL MANAGEMENT, LLC | 491,750 | $45,364 |
| UBS ASSET MANAGEMENT AMERICAS INC | 463,316 | $42,732 |
| abrdn plc | 460,901 | $42,509 |
| BNP PARIBAS ARBITRAGE, SA | 454,810 | $41,947 |
| EVENTIDE ASSET MANAGEMENT, LLC | 440,205 | $40,601 |
| UBS Group AG | 411,329 | $37,937 |
| RENAISSANCE TECHNOLOGIES LLC | 410,768 | $37,885 |
| Amundi | 364,622 | $33,629 |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 348,500 | $32,142 |
| DIMENSIONAL FUND ADVISORS LP | 341,397 | $31,488 |
| BAMCO INC /NY/ | 337,486 | $31,126 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 308,171 | $28 |
| Jefferies Financial Group Inc. | 307,588 | $28,369 |
| Soleus Capital Management, L.P. | 299,399 | $27,614 |
| GOLDMAN SACHS GROUP INC | 284,885 | $26,275 |
| JANE STREET GROUP, LLC | 277,199 | $25,566 |
| Jain Global LLC | 268,250 | $24,741 |
| Assenagon Asset Management S.A. | 264,999 | $24,441 |
| Invesco Ltd. | 261,374 | $24,107 |
| FRANKLIN RESOURCES INC | 231,438 | $21,346 |
| Bank of New York Mellon Corp | 215,780 | $19,901 |
| Trexquant Investment LP | 213,249 | $19,668 |
| Regal Partners Ltd | 211,304 | $19,489 |
| BANK OF AMERICA CORP /DE/ | 210,126 | $19,380 |
| Champlain Investment Partners, LLC | 203,098 | $18,732 |
| MILLENNIUM MANAGEMENT LLC | 202,140 | $18,643 |
| KEYBANK NATIONAL ASSOCIATION/OH | 200,042 | $18,450 |
| NORTHERN TRUST CORP | 197,456 | $18,211 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 194,155 | $17,907 |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 188,100 | $17,348 |
| BALYASNY ASSET MANAGEMENT L.P. | 187,226 | $17,268 |
| Nuveen, LLC | 159,421 | $14,703 |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 142,007 | $13,097 |
| RA CAPITAL MANAGEMENT, L.P. | 141,964 | $13,093 |
| FMR LLC | 137,306 | $12,664 |
| Connor, Clark & Lunn Investment Management Ltd. | 136,420 | $12,582 |
| Rock Springs Capital Management LP | 131,000 | $12,082 |
| NORGES BANK | 129,570 | $11,950 |
| PRINCIPAL FINANCIAL GROUP INC | 125,519 | $11,577 |
| CAPITAL FUND MANAGEMENT S.A. | 122,706 | $11,317 |
| HRT FINANCIAL LP | 121,761 | $11 |
| BROWN CAPITAL MANAGEMENT LLC | 119,935 | $11,062 |
| Rheos Capital Works Inc. | 117,400 | $11 |
| WASATCH ADVISORS LP | 116,068 | $10,705 |
| TUDOR INVESTMENT CORP ET AL | 112,873 | $10,410 |
| CANADA PENSION PLAN INVESTMENT BOARD | 105,500 | $9,730 |
| Bellevue Group AG | 100,761 | $9,293 |
| RIVERBRIDGE PARTNERS LLC | 97,111 | $8,957 |
| Public Sector Pension Investment Board | 91,472 | $8,436 |
| AMERIPRISE FINANCIAL INC | 91,277 | $8,419 |
| ING GROEP NV | 88,300 | $8,144 |
| BARCLAYS PLC | 85,655 | $7,900 |
| GLENMEDE TRUST CO NA | 81,986 | $7,562 |
| Walleye Capital LLC | 78,217 | $7,214 |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 76,028 | $7,012 |
| Integral Health Asset Management, LLC | 75,000 | $6,917 |
| Bridgewater Associates, LP | 71,727 | $6,615 |
| Y-Intercept (Hong Kong) Ltd | 70,635 | $6,515 |
| Legal & General Group Plc | 69,756 | $6,434 |
| NEW YORK STATE COMMON RETIREMENT FUND | 68,774 | $6,343 |
| CREDIT AGRICOLE S A | 67,695 | $6,244 |
| RHUMBLINE ADVISERS | 65,894 | $6,077 |
| Voleon Capital Management LP | 63,627 | $5,868 |
| NOMURA HOLDINGS INC | 60,950 | $5,621 |
| TWO SIGMA INVESTMENTS, LP | 59,515 | $5,489 |
| MAIRS & POWER INC | 57,616 | $5,314 |
| Swiss National Bank | 55,500 | $5,119 |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | 52,246 | $4,819 |
| SEI INVESTMENTS CO | 50,940 | $4,698 |
| Gotham Asset Management, LLC | 48,547 | $4,477 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 48,497 | $4,473 |
| ALGERT GLOBAL LLC | 46,250 | $4 |
| XTX Topco Ltd | 45,783 | $4,223 |
| JPMORGAN CHASE & CO | 45,388 | $4,186 |
| LAZARD ASSET MANAGEMENT LLC | 44,981 | $4,149 |
| HSBC HOLDINGS PLC | 43,328 | $4,004 |
| Man Group plc | 41,425 | $3,821 |
| BANK OF NOVA SCOTIA | 40,042 | $3,693 |
| ExodusPoint Capital Management, LP | 38,896 | $3,587 |
| SG Americas Securities, LLC | 38,449 | $4 |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 38,404 | $3,542 |
| Bullseye Asset Management LLC | 36,128 | $3 |
| Rhenman & Partners Asset Management AB | 35,800 | $3,302 |
| CITIGROUP INC | 34,672 | $3,198 |
| EFG International AG | 33,813 | $3,114 |
| 240 other institutions | 1,478,312 | $115,831 |