| Nextech Invest, Ltd. | 7,162,637 | $58,590 |
| EcoR1 Capital, LLC | 6,728,116 | $55,036 |
| VIKING GLOBAL INVESTORS LP | 6,572,691 | $53,765 |
| BlackRock, Inc. | 5,875,053 | $48,058 |
| VR Adviser, LLC | 5,676,230 | $46,432 |
| Pfizer Inc | 5,376,344 | $43,978 |
| VANGUARD GROUP INC | 4,541,974 | $37,153 |
| SR ONE CAPITAL MANAGEMENT, LP | 4,514,929 | $37,754 |
| ALKEON CAPITAL MANAGEMENT LLC | 4,504,096 | $36,844 |
| STATE STREET CORP | 4,258,397 | $34,834 |
| NEA Management Company, LLC | 4,118,621 | $33,690 |
| ORBIMED ADVISORS LLC | 3,641,756 | $29,790 |
| Column Group LLC | 3,540,777 | $28,964 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,295,122 | $27 |
| Point72 Asset Management, L.P. | 2,923,077 | $23,911 |
| FMR LLC | 2,478,922 | $20,278 |
| CITADEL ADVISORS LLC | 2,434,710 | $19,916 |
| Paradigm Biocapital Advisors LP | 2,401,217 | $19,642 |
| Vivo Capital, LLC | 2,118,384 | $17,328 |
| First Turn Management, LLC | 2,010,307 | $16,444 |
| GOLDMAN SACHS GROUP INC | 1,939,285 | $15,863 |
| MPM BioImpact LLC | 1,798,717 | $14,714 |
| GEODE CAPITAL MANAGEMENT, LLC | 1,750,694 | $14,323 |
| ROYCE & ASSOCIATES LP | 1,507,301 | $12,330 |
| DIMENSIONAL FUND ADVISORS LP | 1,227,230 | $10,038 |
| FRANKLIN RESOURCES INC | 1,212,547 | $9,919 |
| Qube Research & Technologies Ltd | 1,205,429 | $9,860 |
| Integral Health Asset Management, LLC | 1,200,000 | $9,816 |
| MORGAN STANLEY | 1,194,073 | $9,768 |
| SILVERARC CAPITAL MANAGEMENT, LLC | 1,116,604 | $9,134 |
| ArrowMark Colorado Holdings LLC | 1,063,769 | $8,702 |
| Siren, L.L.C. | 1,007,575 | $8,242 |
| SPHERA FUNDS MANAGEMENT LTD. | 1,004,378 | $8,216 |
| Euclidean Capital LLC | 989,410 | $8,093 |
| EVENTIDE ASSET MANAGEMENT, LLC | 952,371 | $7,790 |
| BALYASNY ASSET MANAGEMENT L.P. | 950,214 | $7,773 |
| NORTHERN TRUST CORP | 885,475 | $7,243 |
| UBS Group AG | 734,858 | $6,011 |
| BARCLAYS PLC | 718,535 | $5,878 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 621,086 | $5,080 |
| NEXTBio Capital Management LP | 615,720 | $5,037 |
| RENAISSANCE TECHNOLOGIES LLC | 572,724 | $4,685 |
| LORD, ABBETT & CO. LLC | 564,253 | $5 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 549,000 | $4,491 |
| Blue Owl Capital Holdings LP | 515,000 | $4,213 |
| BANK OF AMERICA CORP /DE/ | 507,510 | $4,151 |
| Polar Capital Holdings Plc | 502,364 | $4,109 |
| Logos Global Management LP | 450,000 | $3,681 |
| Redmile Group, LLC | 448,110 | $3,666 |
| JPMORGAN CHASE & CO | 414,786 | $3,393 |
| Connor, Clark & Lunn Investment Management Ltd. | 350,884 | $2,870 |
| Y-Intercept (Hong Kong) Ltd | 341,423 | $2,793 |
| VICTORY CAPITAL MANAGEMENT INC | 332,760 | $2,722 |
| Atom Investors LP | 289,962 | $2,372 |
| Kalehua Capital Management LLC | 267,059 | $2,185 |
| SUPERSTRING CAPITAL MANAGEMENT LP | 255,370 | $2,089 |
| Woodline Partners LP | 246,534 | $2,017 |
| JANE STREET GROUP, LLC | 244,033 | $1,996 |
| Squarepoint Ops LLC | 229,383 | $1,876 |
| BOOTHBAY FUND MANAGEMENT, LLC | 218,610 | $1,788 |
| Russell Investments Group, Ltd. | 207,037 | $1,694 |
| WELLINGTON MANAGEMENT GROUP LLP | 191,823 | $1,569 |
| Bank of New York Mellon Corp | 187,921 | $1,537 |
| Rafferty Asset Management, LLC | 177,179 | $1,449 |
| AQR CAPITAL MANAGEMENT LLC | 174,279 | $1,426 |
| Hennion & Walsh Asset Management, Inc. | 170,072 | $1,391 |
| TD Asset Management Inc | 169,830 | $1,389 |
| Ishara Investments LP | 160,000 | $1,309 |
| CITIGROUP INC | 154,149 | $1,261 |
| Nuveen, LLC | 144,403 | $1,181 |
| DAFNA Capital Management LLC | 141,045 | $1,154 |
| AMERICAN CENTURY COMPANIES INC | 134,930 | $1,104 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 128,649 | $1,042 |
| STATE OF WISCONSIN INVESTMENT BOARD | 124,345 | $1,017 |
| XTX Topco Ltd | 110,565 | $904 |
| Invesco Ltd. | 109,742 | $898 |
| ExodusPoint Capital Management, LP | 108,835 | $890 |
| MILLENNIUM MANAGEMENT LLC | 97,432 | $797 |
| Brevan Howard Capital Management LP | 89,532 | $732 |
| Swiss National Bank | 86,200 | $705 |
| WELLS FARGO & COMPANY/MN | 82,532 | $675 |
| Graham Capital Management, L.P. | 81,576 | $667 |
| RHUMBLINE ADVISERS | 77,706 | $636 |
| GSA CAPITAL PARTNERS LLP | 70,634 | $1 |
| PROFUND ADVISORS LLC | 65,160 | $533 |
| ALLIANCEBERNSTEIN L.P. | 63,810 | $522 |
| UBS ASSET MANAGEMENT AMERICAS INC | 50,782 | $415 |
| DEUTSCHE BANK AG\ | 44,937 | $368 |
| AlphaQuest LLC | 44,387 | $363 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 41,057 | $335 |
| SG Americas Securities, LLC | 41,016 | $0 |
| ALGERT GLOBAL LLC | 40,510 | $0 |
| BNP PARIBAS ARBITRAGE, SA | 40,115 | $328 |
| Optimize Financial Inc | 39,612 | $324 |
| LMR Partners LLP | 35,267 | $288 |
| MetLife Investment Management, LLC | 33,970 | $278 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 33,959 | $278 |
| Legal & General Group Plc | 33,839 | $277 |
| VARCOV Co. | 32,036 | $262 |
| Virtus Investment Advisers, LLC | 28,361 | $232 |
| 64 other institutions | 636,106 | $5,034 |