| SB INVESTMENT ADVISERS (UK) LTD | 27,904,963 | $236,076 |
| Commodore Capital LP | 17,000,000 | $143,820 |
| Point72 Asset Management, L.P. | 13,859,172 | $117,249 |
| BlackRock, Inc. | 13,228,502 | $111,913 |
| Casdin Capital, LLC | 13,003,574 | $110,010 |
| VANGUARD GROUP INC | 9,691,445 | $81,990 |
| Bellevue Group AG | 8,345,364 | $70,602 |
| STATE STREET CORP | 6,426,111 | $54,365 |
| Nextech Invest, Ltd. | 4,701,506 | $39,775 |
| GEODE CAPITAL MANAGEMENT, LLC | 3,409,363 | $28,849 |
| TCG Crossover Management, LLC | 3,220,186 | $27,243 |
| Spruce Street Capital LP | 2,984,125 | $25,246 |
| DIMENSIONAL FUND ADVISORS LP | 2,480,350 | $20,983 |
| MPM BioImpact LLC | 2,232,451 | $18,887 |
| BALYASNY ASSET MANAGEMENT L.P. | 2,099,912 | $17,765 |
| MORGAN STANLEY | 2,018,464 | $17,076 |
| PERCEPTIVE ADVISORS LLC | 1,903,245 | $16,101 |
| GOLDMAN SACHS GROUP INC | 1,859,634 | $15,733 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,645,403 | $14 |
| Alphabet Inc. | 1,568,753 | $13,272 |
| TWO SIGMA INVESTMENTS, LP | 1,560,265 | $13,200 |
| Kynam Capital Management, LP | 1,424,259 | $12,049 |
| TWO SIGMA ADVISERS, LP | 1,289,800 | $10,912 |
| AQR CAPITAL MANAGEMENT LLC | 1,163,124 | $9,840 |
| BAKER BROS. ADVISORS LP | 1,160,117 | $9,815 |
| ExodusPoint Capital Management, LP | 1,141,880 | $9,660 |
| NORTHERN TRUST CORP | 1,138,688 | $9,633 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,136,702 | $9,616 |
| BANK OF AMERICA CORP /DE/ | 1,040,949 | $8,806 |
| Foresite Capital Management IV, LLC | 1,000,000 | $8,460 |
| Kalehua Capital Management LLC | 901,457 | $7,626 |
| MILLENNIUM MANAGEMENT LLC | 896,909 | $7,588 |
| Invesco Ltd. | 865,481 | $7,322 |
| NORGES BANK | 837,417 | $7,085 |
| Woodline Partners LP | 679,115 | $5,745 |
| RENAISSANCE TECHNOLOGIES LLC | 647,899 | $5,481 |
| Allianz Asset Management GmbH | 560,298 | $4,740 |
| HighVista Strategies LLC | 545,079 | $4,611 |
| ArrowMark Colorado Holdings LLC | 541,124 | $4,578 |
| Elmind Capital, LP | 536,946 | $4,543 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 500,000 | $4,230 |
| Eversept Partners, LP | 489,137 | $4,138 |
| Trexquant Investment LP | 472,045 | $3,994 |
| Rhenman & Partners Asset Management AB | 460,000 | $3,892 |
| BESSEMER GROUP INC | 457,869 | $4 |
| ACADIAN ASSET MANAGEMENT LLC | 456,648 | $4 |
| Hudson Bay Capital Management LP | 451,500 | $3,820 |
| AMERICAN CENTURY COMPANIES INC | 432,493 | $3,659 |
| JPMORGAN CHASE & CO | 425,958 | $3,604 |
| CONGRESS ASSET MANAGEMENT CO /MA | 414,167 | $3,504 |
| BARCLAYS PLC | 414,143 | $3,504 |
| SILVERARC CAPITAL MANAGEMENT, LLC | 398,167 | $3,368 |
| Connor, Clark & Lunn Investment Management Ltd. | 389,563 | $3,296 |
| Bank of New York Mellon Corp | 378,703 | $3,204 |
| Susquehanna Portfolio Strategies, LLC | 339,080 | $2,869 |
| Nuveen, LLC | 300,464 | $2,542 |
| UBS Group AG | 296,017 | $2,504 |
| RAYMOND JAMES FINANCIAL INC | 259,411 | $2,195 |
| Raiffeisen Bank International AG | 250,000 | $2,088 |
| Swiss National Bank | 238,000 | $2,013 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 222,929 | $1,886 |
| SG Americas Securities, LLC | 220,949 | $2 |
| RHUMBLINE ADVISERS | 215,741 | $1,825 |
| UBS ASSET MANAGEMENT AMERICAS INC | 209,848 | $1,775 |
| Rafferty Asset Management, LLC | 193,756 | $1,639 |
| OSAIC HOLDINGS, INC. | 186,388 | $1,577 |
| TD Asset Management Inc | 181,988 | $1,540 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 177,486 | $1,487 |
| IEQ CAPITAL, LLC | 162,285 | $1,373 |
| FMR LLC | 162,222 | $1,372 |
| WELLS FARGO & COMPANY/MN | 157,892 | $1,336 |
| XTX Topco Ltd | 157,406 | $1,332 |
| ALGERT GLOBAL LLC | 146,500 | $1 |
| ALLIANCEBERNSTEIN L.P. | 145,251 | $1,229 |
| ALPS ADVISORS INC | 142,321 | $1,204 |
| Sanctuary Advisors, LLC | 142,228 | $1,203 |
| DEUTSCHE BANK AG\ | 123,994 | $1,049 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 117,677 | $996 |
| CITADEL ADVISORS LLC | 114,143 | $966 |
| NEOS Investment Management LLC | 113,230 | $958 |
| TEMA ETFS LLC | 111,555 | $944 |
| Legal & General Group Plc | 109,208 | $924 |
| HIMENSION CAPITAL (SINGAPORE) PTE. LTD. | 104,953 | $888 |
| STATE OF WISCONSIN INVESTMENT BOARD | 101,160 | $856 |
| ICONIQ Capital, LLC | 94,697 | $801 |
| Squarepoint Ops LLC | 94,210 | $797 |
| Man Group plc | 87,037 | $736 |
| Creative Planning | 85,836 | $726 |
| TUDOR INVESTMENT CORP ET AL | 84,163 | $712 |
| Jump Financial, LLC | 82,559 | $698 |
| Engineers Gate Manager LP | 78,368 | $663 |
| MetLife Investment Management, LLC | 77,536 | $656 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 76,679 | $647 |
| JANE STREET GROUP, LLC | 76,476 | $647 |
| Seven Fleet Capital Management LP | 73,000 | $618 |
| PROFUND ADVISORS LLC | 72,586 | $614 |
| CWM, LLC | 67,603 | $1 |
| Jain Global LLC | 66,587 | $563 |
| Allspring Global Investments Holdings, LLC | 65,447 | $535 |
| Schonfeld Strategic Advisors LLC | 61,853 | $523 |
| 124 other institutions | 2,108,744 | $16,784 |