| VANGUARD GROUP INC | 3,310,519 | $587,418 |
| BlackRock, Inc. | 2,813,989 | $499,314 |
| SANDS CAPITAL MANAGEMENT, LLC | 1,699,645 | $301,585 |
| Artisan Partners Limited Partnership | 1,511,992 | $268,288 |
| Capital Research Global Investors | 1,184,746 | $210,221 |
| RTW INVESTMENTS, LP | 1,181,990 | $209,732 |
| GEODE CAPITAL MANAGEMENT, LLC | 858,405 | $152,337 |
| UBS ASSET MANAGEMENT AMERICAS INC | 829,862 | $147,251 |
| MILLENNIUM MANAGEMENT LLC | 826,376 | $146,632 |
| STATE STREET CORP | 764,839 | $135,713 |
| JPMORGAN CHASE & CO | 758,587 | $134,604 |
| BLAIR WILLIAM & CO/IL | 718,797 | $127,543 |
| EVENTIDE ASSET MANAGEMENT, LLC | 692,486 | $122,880 |
| Holocene Advisors, LP | 683,568 | $121,292 |
| FULLER & THALER ASSET MANAGEMENT, INC. | 639,423 | $113,459 |
| FMR LLC | 628,766 | $111,568 |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 606,969 | $107,701 |
| BNP Paribas Investment Partners S.A. | 583,014 | $103 |
| Stephens Investment Management Group LLC | 519,325 | $92,149 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 502,120 | $89 |
| Invesco Ltd. | 498,385 | $88,433 |
| WELLINGTON MANAGEMENT GROUP LLP | 408,256 | $72,441 |
| Allspring Global Investments Holdings, LLC | 407,409 | $71,386 |
| LOOMIS SAYLES & CO L P | 392,077 | $69,570 |
| D. E. Shaw & Co., Inc. | 360,669 | $63,997 |
| BANK OF AMERICA CORP /DE/ | 354,770 | $62,950 |
| MACKENZIE FINANCIAL CORP | 347,304 | $61,896 |
| GOLDMAN SACHS GROUP INC | 329,135 | $58,402 |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 325,063 | $57,679 |
| BESSEMER GROUP INC | 321,984 | $57 |
| FRED ALGER MANAGEMENT, LLC | 310,582 | $55,110 |
| Polar Capital Holdings Plc | 308,100 | $54,669 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 286,124 | $50,770 |
| NORTHERN TRUST CORP | 279,070 | $49,518 |
| LORD, ABBETT & CO. LLC | 277,212 | $49 |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 267,968 | $47,548 |
| Rock Springs Capital Management LP | 235,000 | $41,698 |
| Assenagon Asset Management S.A. | 225,205 | $39,960 |
| Point72 Asset Management, L.P. | 219,468 | $38,942 |
| BRAIDWELL LP | 217,345 | $38,566 |
| SEI INVESTMENTS CO | 203,355 | $36,083 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 196,075 | $34,792 |
| BARCLAYS PLC | 193,975 | $34,419 |
| JANE STREET GROUP, LLC | 192,391 | $34,138 |
| CITIGROUP INC | 190,335 | $33,773 |
| DEUTSCHE BANK AG\ | 187,661 | $33,299 |
| NEXT CENTURY GROWTH INVESTORS LLC | 172,838 | $30,668 |
| MORGAN STANLEY | 169,991 | $30,163 |
| BALYASNY ASSET MANAGEMENT L.P. | 167,274 | $29,681 |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 162,053 | $28,938 |
| First Light Asset Management, LLC | 153,871 | $27,303 |
| RAYMOND JAMES FINANCIAL INC | 153,806 | $27,426 |
| UBS Group AG | 153,218 | $27,187 |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 150,284 | $26,666 |
| Qube Research & Technologies Ltd | 144,614 | $25,660 |
| JENNISON ASSOCIATES LLC | 139,059 | $24,675 |
| Nuveen, LLC | 133,675 | $23,719 |
| Integral Health Asset Management, LLC | 130,000 | $23,067 |
| NEW YORK STATE COMMON RETIREMENT FUND | 129,732 | $23,020 |
| Ophir Asset Management Pty Ltd | 127,697 | $22,659 |
| Walleye Capital LLC | 127,596 | $22,641 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 125,000 | $22,180 |
| AMERIPRISE FINANCIAL INC | 123,621 | $21,935 |
| OBERWEIS ASSET MANAGEMENT INC/ | 119,700 | $21,240 |
| FRANKLIN RESOURCES INC | 118,578 | $21,040 |
| Bank of New York Mellon Corp | 112,119 | $19,894 |
| SEGALL BRYANT & HAMILL, LLC | 111,697 | $19,820 |
| PERCEPTIVE ADVISORS LLC | 108,000 | $19,164 |
| FEDERATED HERMES, INC. | 106,407 | $18,881 |
| RENAISSANCE TECHNOLOGIES LLC | 103,900 | $18,436 |
| Squarepoint Ops LLC | 93,708 | $16,628 |
| M&G PLC | 84,138 | $14,892 |
| C WorldWide Group Holding A/S | 80,000 | $14 |
| Trexquant Investment LP | 78,653 | $13,956 |
| Engineers Gate Manager LP | 77,119 | $13,684 |
| BNP PARIBAS ARBITRAGE, SA | 73,651 | $13,069 |
| WCM INVESTMENT MANAGEMENT, LLC | 73,292 | $13,088 |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 71,048 | $12,607 |
| PRINCIPAL FINANCIAL GROUP INC | 69,421 | $12,318 |
| Swiss National Bank | 63,400 | $11,250 |
| Freestone Grove Partners LP | 63,140 | $11,204 |
| FIRST TRUST ADVISORS LP | 60,802 | $10,789 |
| TimesSquare Capital Management, LLC | 59,822 | $10,615 |
| PEREGRINE CAPITAL MANAGEMENT LLC | 56,868 | $10,091 |
| NORGES BANK | 56,237 | $9,979 |
| Man Group plc | 56,202 | $9,972 |
| Jain Global LLC | 54,844 | $9,732 |
| Legal & General Group Plc | 52,070 | $9,239 |
| STATE OF WISCONSIN INVESTMENT BOARD | 51,153 | $9,077 |
| CASTLEARK MANAGEMENT LLC | 50,193 | $8,906 |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 47,898 | $8,499 |
| WELLS FARGO & COMPANY/MN | 45,286 | $8,036 |
| VICTORY CAPITAL MANAGEMENT INC | 43,215 | $7,668 |
| Connor, Clark & Lunn Investment Management Ltd. | 42,118 | $7,473 |
| STEADFAST CAPITAL MANAGEMENT LP | 41,000 | $7,275 |
| RHUMBLINE ADVISERS | 40,610 | $7,206 |
| PRUDENTIAL FINANCIAL INC | 40,424 | $7,173 |
| AQR CAPITAL MANAGEMENT LLC | 40,165 | $7,127 |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | 39,747 | $7,053 |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 38,534 | $6,837 |
| 233 other institutions | 1,340,025 | $219,066 |