| BlackRock, Inc. | 8,194,218 | $331,046 |
| MORGAN STANLEY | 7,945,608 | $321,003 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 5,550,000 | $224,220 |
| VANGUARD GROUP INC | 5,523,948 | $223,167 |
| Vivo Capital, LLC | 5,346,928 | $216,016 |
| Vestal Point Capital, LP | 4,500,000 | $181,800 |
| Avoro Capital Advisors LLC | 4,350,000 | $175,740 |
| JANUS HENDERSON GROUP PLC | 3,379,569 | $136,496 |
| CITADEL ADVISORS LLC | 3,166,642 | $127,932 |
| Capitolis Liquid Global Markets LLC | 3,045,200 | $123,026 |
| Holocene Advisors, LP | 2,775,493 | $112,130 |
| FRANKLIN RESOURCES INC | 2,731,312 | $110,345 |
| LORD, ABBETT & CO. LLC | 2,712,399 | $110 |
| ORBIMED ADVISORS LLC | 2,153,300 | $86,993 |
| GEODE CAPITAL MANAGEMENT, LLC | 2,096,642 | $84,723 |
| AMERIPRISE FINANCIAL INC | 1,894,381 | $76,533 |
| STATE STREET CORP | 1,775,922 | $71,747 |
| JPMORGAN CHASE & CO | 1,773,026 | $71,630 |
| ACORN CAPITAL ADVISORS, LLC | 1,746,264 | $70,549 |
| Nearwater Capital Markets, Ltd | 1,704,800 | $68,874 |
| Ikarian Capital, LLC | 1,596,378 | $64,494 |
| Pictet Asset Management Holding SA | 1,577,116 | $63,746 |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 1,515,400 | $61,222 |
| Commodore Capital LP | 1,475,000 | $59,590 |
| TORONTO DOMINION BANK | 1,400,802 | $56,592 |
| Woodline Partners LP | 1,377,283 | $55,642 |
| ALLIANCEBERNSTEIN L.P. | 1,288,079 | $52,038 |
| Candriam S.C.A. | 1,262,303 | $50,999 |
| DIMENSIONAL FUND ADVISORS LP | 1,247,763 | $50,410 |
| D. E. Shaw & Co., Inc. | 1,154,029 | $46,623 |
| Nuveen, LLC | 1,078,157 | $43,558 |
| GOLDMAN SACHS GROUP INC | 1,062,984 | $42,945 |
| Capital International Investors | 1,060,000 | $42,824 |
| FMR LLC | 1,026,863 | $41,485 |
| MILLENNIUM MANAGEMENT LLC | 987,306 | $39,887 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 974,312 | $39 |
| BAKER BROS. ADVISORS LP | 950,000 | $38,380 |
| BALYASNY ASSET MANAGEMENT L.P. | 891,903 | $36,033 |
| MARSHALL WACE, LLP | 878,583 | $35,495 |
| First Turn Management, LLC | 872,049 | $35,231 |
| SAMLYN CAPITAL, LLC | 814,875 | $32,921 |
| Paradigm Biocapital Advisors LP | 810,286 | $32,736 |
| WELLINGTON MANAGEMENT GROUP LLP | 788,659 | $31,862 |
| Deep Track Capital, LP | 769,048 | $31,070 |
| Schonfeld Strategic Advisors LLC | 754,237 | $30,471 |
| Logos Global Management LP | 750,000 | $30,300 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 737,160 | $29,781 |
| NORTHERN TRUST CORP | 664,444 | $26,844 |
| FARALLON CAPITAL MANAGEMENT LLC | 642,000 | $25,937 |
| ACUTA CAPITAL PARTNERS, LLC | 637,095 | $25,739 |
| Parkman Healthcare Partners LLC | 620,877 | $25,083 |
| Invesco Ltd. | 606,247 | $24,492 |
| BRAIDWELL LP | 575,321 | $23,243 |
| Point72 Asset Management, L.P. | 573,700 | $23,177 |
| BANK OF AMERICA CORP /DE/ | 553,609 | $22,366 |
| NEXTBio Capital Management LP | 551,190 | $22,268 |
| Affinity Asset Advisors, LLC | 550,000 | $22,220 |
| Mariner, LLC | 542,052 | $21,899 |
| ADAR1 Capital Management, LLC | 541,615 | $21,881 |
| Blackstone Inc. | 476,754 | $19,261 |
| RENAISSANCE TECHNOLOGIES LLC | 466,847 | $18,861 |
| BOOTHBAY FUND MANAGEMENT, LLC | 447,008 | $18,059 |
| SUPERSTRING CAPITAL MANAGEMENT LP | 443,777 | $17,929 |
| KVP Capital Advisors, LP | 440,000 | $17,776 |
| STEMPOINT CAPITAL LP | 429,198 | $17,340 |
| Integral Health Asset Management, LLC | 425,000 | $17,170 |
| DEUTSCHE BANK AG\ | 401,446 | $16,218 |
| NORGES BANK | 395,205 | $15,966 |
| ExodusPoint Capital Management, LP | 375,673 | $15,177 |
| Boxer Capital Management, LLC | 375,000 | $15,150 |
| Evergreen Quality Fund GP, Ltd. | 360,200 | $14,552 |
| DIADEMA PARTNERS LP | 345,880 | $13,974 |
| UBS Group AG | 325,968 | $13,169 |
| Atika Capital Management LLC | 321,165 | $12,975 |
| Patient Square Capital LP | 320,000 | $12,928 |
| Trails Edge Capital Partners, LP | 300,000 | $12,120 |
| Eagle Health Investments LP | 275,090 | $11,114 |
| Bank of New York Mellon Corp | 258,562 | $10,446 |
| Russell Investments Group, Ltd. | 247,027 | $9,980 |
| SummitTX Capital, L.P. | 215,854 | $8,721 |
| Soleus Capital Management, L.P. | 212,710 | $8,593 |
| J. Goldman & Co LP | 203,192 | $8,209 |
| Monashee Investment Management LLC | 197,313 | $7,971 |
| AMERICAN CENTURY COMPANIES INC | 192,751 | $7,787 |
| Squadron Capital Management LLC | 190,000 | $7,676 |
| ACADIAN ASSET MANAGEMENT LLC | 189,025 | $8 |
| HighVista Strategies LLC | 175,462 | $7,089 |
| ARMISTICE CAPITAL, LLC | 172,479 | $6,968 |
| BARCLAYS PLC | 171,186 | $6,916 |
| Nicholas Investment Partners, LP | 165,781 | $6,698 |
| Capricorn Fund Managers Ltd | 151,436 | $6,118 |
| Trexquant Investment LP | 150,049 | $6,062 |
| CANADA PENSION PLAN INVESTMENT BOARD | 144,800 | $5,850 |
| Connor, Clark & Lunn Investment Management Ltd. | 137,478 | $5,554 |
| Catalio Capital Management, LP | 136,958 | $5,533 |
| HRT FINANCIAL LP | 124,709 | $5 |
| Voya Investment Management LLC | 122,395 | $4,945 |
| Persistent Asset Partners Ltd | 113,555 | $4,588 |
| PLATINUM INVESTMENT MANAGEMENT LTD | 110,734 | $4,474 |
| EAM Investors, LLC | 108,986 | $4,403 |
| 146 other institutions | 3,159,484 | $125,085 |