| FMR LLC | 16,796,979 | $217,185 |
| BlackRock, Inc. | 13,541,448 | $175,091 |
| VANGUARD GROUP INC | 10,958,209 | $141,690 |
| Soleus Capital Management, L.P. | 8,530,665 | $110,301 |
| MORGAN STANLEY | 5,069,895 | $65,554 |
| STATE STREET CORP | 2,577,239 | $33,324 |
| GEODE CAPITAL MANAGEMENT, LLC | 2,476,646 | $32,029 |
| Quantinno Capital Management LP | 2,010,248 | $25,993 |
| RENAISSANCE TECHNOLOGIES LLC | 1,387,754 | $17,944 |
| Palo Alto Investors LP | 1,298,964 | $16,796 |
| Nuveen, LLC | 1,273,349 | $16,464 |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 1,223,755 | $15,823 |
| GOLDMAN SACHS GROUP INC | 1,178,045 | $15,232 |
| BAILLIE GIFFORD & CO | 1,121,274 | $14,498 |
| AMERICAN CENTURY COMPANIES INC | 1,041,532 | $13,467 |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 1,019,969 | $13,484 |
| C WorldWide Group Holding A/S | 971,784 | $13 |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 927,400 | $11,991 |
| Point72 Asset Management, L.P. | 900,496 | $11,643 |
| ALGERT GLOBAL LLC | 878,998 | $11 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 876,816 | $11,337 |
| NORTHERN TRUST CORP | 858,986 | $11,107 |
| D. E. Shaw & Co., Inc. | 822,385 | $10,633 |
| DIMENSIONAL FUND ADVISORS LP | 752,143 | $9,727 |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 707,609 | $9,149 |
| CITADEL ADVISORS LLC | 675,831 | $8,738 |
| Connor, Clark & Lunn Investment Management Ltd. | 661,297 | $8,551 |
| MILLENNIUM MANAGEMENT LLC | 646,666 | $8,361 |
| Jump Financial, LLC | 561,237 | $7,257 |
| Vestal Point Capital, LP | 525,000 | $6,788 |
| BARCLAYS PLC | 447,255 | $5,783 |
| AQR CAPITAL MANAGEMENT LLC | 414,742 | $5,363 |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 407,204 | $5,265 |
| Legal & General Group Plc | 406,664 | $5,258 |
| JPMORGAN CHASE & CO | 402,882 | $5,209 |
| IEQ CAPITAL, LLC | 378,974 | $4,900 |
| BNP Paribas Investment Partners S.A. | 373,392 | $5 |
| TWO SIGMA INVESTMENTS, LP | 352,459 | $4,557 |
| BANK OF AMERICA CORP /DE/ | 342,953 | $4,434 |
| JANE STREET GROUP, LLC | 319,814 | $4,135 |
| DEUTSCHE BANK AG\ | 314,080 | $4,061 |
| Qube Research & Technologies Ltd | 313,218 | $4,050 |
| Bank of New York Mellon Corp | 298,528 | $3,860 |
| Engineers Gate Manager LP | 291,332 | $3,767 |
| Susquehanna Portfolio Strategies, LLC | 289,359 | $3,741 |
| TUDOR INVESTMENT CORP ET AL | 284,645 | $3,680 |
| SG Americas Securities, LLC | 278,806 | $4 |
| FRANKLIN RESOURCES INC | 264,894 | $3,425 |
| ACADIAN ASSET MANAGEMENT LLC | 259,078 | $3 |
| HRT FINANCIAL LP | 250,862 | $3 |
| BNP PARIBAS ARBITRAGE, SA | 244,072 | $3,156 |
| Quantbot Technologies LP | 238,360 | $3,082 |
| UBS ASSET MANAGEMENT AMERICAS INC | 226,500 | $2,929 |
| Swiss National Bank | 209,500 | $2,709 |
| CITIGROUP INC | 206,819 | $2,674 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 204,053 | $2,638 |
| TWO SIGMA ADVISERS, LP | 192,800 | $2,493 |
| Verition Fund Management LLC | 168,873 | $2,184 |
| Russell Investments Group, Ltd. | 155,199 | $2,007 |
| Y-Intercept (Hong Kong) Ltd | 153,518 | $1,985 |
| Birchview Capital, LP | 152,100 | $1,967 |
| UBS Group AG | 148,519 | $1,920 |
| Schonfeld Strategic Advisors LLC | 144,728 | $1,871 |
| WELLS FARGO & COMPANY/MN | 140,813 | $1,821 |
| ALLIANCEBERNSTEIN L.P. | 136,030 | $1,759 |
| Hillsdale Investment Management Inc. | 131,800 | $1,704 |
| RHUMBLINE ADVISERS | 124,960 | $1,616 |
| Eversept Partners, LP | 120,978 | $1,564 |
| FEDERATED HERMES, INC. | 115,136 | $1,489 |
| Caprock Group, LLC | 111,546 | $1,442 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 105,412 | $1,363 |
| FOX RUN MANAGEMENT, L.L.C. | 99,405 | $1,285 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 99,304 | $1,284 |
| Corient Private Wealth LLC | 97,368 | $608 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 94,094 | $1 |
| Focus Partners Wealth | 88,181 | $1,140 |
| CANADA PENSION PLAN INVESTMENT BOARD | 86,900 | $1,124 |
| Summit Trail Advisors, LLC | 85,264 | $1,102 |
| Aquatic Capital Management LLC | 83,686 | $1,082 |
| EXCHANGE TRADED CONCEPTS, LLC | 73,720 | $953 |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt | 72,949 | $943 |
| CAPITAL FUND MANAGEMENT S.A. | 71,286 | $922 |
| INTECH INVESTMENT MANAGEMENT LLC | 68,311 | $883 |
| Invesco Ltd. | 67,968 | $879 |
| XTX Topco Ltd | 58,795 | $760 |
| STRS OHIO | 58,100 | $751 |
| MetLife Investment Management, LLC | 56,930 | $736 |
| Hennion & Walsh Asset Management, Inc. | 54,245 | $701 |
| Squarepoint Ops LLC | 53,045 | $686 |
| Toroso Investments, LLC | 51,421 | $665 |
| Numerai GP LLC | 51,218 | $662 |
| BOOTHBAY FUND MANAGEMENT, LLC | 50,542 | $654 |
| Campbell & CO Investment Adviser LLC | 49,367 | $638 |
| HSBC HOLDINGS PLC | 46,781 | $614 |
| JANUS HENDERSON GROUP PLC | 45,000 | $582 |
| IMC-Chicago, LLC | 41,909 | $542 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 41,303 | $534 |
| Inscription Capital, LLC | 40,018 | $517 |
| Voleon Capital Management LP | 39,761 | $514 |
| Amundi | 39,676 | $513 |
| 135 other institutions | 1,304,175 | $15,448 |