| VANGUARD GROUP INC | 10,258,621 | $605,772 |
| BAILLIE GIFFORD & CO | 8,741,442 | $516,182 |
| ARK Investment Management LLC | 7,557,583 | $446,275 |
| BlackRock, Inc. | 7,516,110 | $443,826 |
| GC Wealth Management RIA, LLC | 6,761,507 | $399,267 |
| SOFTBANK GROUP CORP. | 5,405,406 | $319,189 |
| JPMORGAN CHASE & CO | 4,909,920 | $289,931 |
| Sumitomo Mitsui Trust Holdings, Inc. | 3,504,823 | $206,960 |
| Nikko Asset Management Americas, Inc. | 3,504,823 | $206,960 |
| MORGAN STANLEY | 2,083,394 | $123,024 |
| GEODE CAPITAL MANAGEMENT, LLC | 1,870,510 | $110,478 |
| FRANKLIN RESOURCES INC | 1,861,782 | $109,938 |
| STATE STREET CORP | 1,616,338 | $95,445 |
| TWO SIGMA INVESTMENTS, LP | 1,591,481 | $93,977 |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 1,573,530 | $92,917 |
| Alphabet Inc. | 1,551,102 | $91,593 |
| UBS Group AG | 1,483,862 | $87,622 |
| D. E. Shaw & Co., Inc. | 1,180,315 | $69,698 |
| Lingotto Investment Management LLP | 1,143,526 | $67,525 |
| BANK OF AMERICA CORP /DE/ | 1,140,489 | $67,346 |
| CITADEL ADVISORS LLC | 902,570 | $53,297 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 856,674 | $50,587 |
| NORGES BANK | 816,840 | $48,234 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 743,268 | $43,890 |
| MARSHALL WACE, LLP | 738,646 | $43,617 |
| GOLDMAN SACHS GROUP INC | 726,483 | $42,899 |
| Clear Street Group Inc. | 723,365 | $42,715 |
| Marex Group plc | 679,823 | $40,144 |
| GILDER GAGNON HOWE & CO LLC | 576,774 | $34,059 |
| UBS ASSET MANAGEMENT AMERICAS INC | 571,783 | $33,764 |
| Legal & General Group Plc | 558,262 | $32,965 |
| FIRST TRUST ADVISORS LP | 521,029 | $30,767 |
| Trexquant Investment LP | 507,884 | $29,991 |
| NORTHERN TRUST CORP | 479,327 | $28,304 |
| MILLENNIUM MANAGEMENT LLC | 471,334 | $27,832 |
| Qube Research & Technologies Ltd | 465,462 | $27,486 |
| WELLINGTON MANAGEMENT GROUP LLP | 432,686 | $25,550 |
| CAPITAL FUND MANAGEMENT S.A. | 386,595 | $22,828 |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 384,491 | $22,704 |
| Patient Capital Management, LLC | 382,128 | $22,565 |
| SG Americas Securities, LLC | 372,043 | $22 |
| Invesco Ltd. | 371,674 | $21,947 |
| KADENSA CAPITAL Ltd | 364,946 | $21,550 |
| BAMCO INC /NY/ | 355,446 | $20,989 |
| WELLS FARGO & COMPANY/MN | 313,411 | $18,507 |
| TWO SIGMA ADVISERS, LP | 311,389 | $18,388 |
| TUDOR INVESTMENT CORP ET AL | 310,892 | $18,358 |
| Bank of New York Mellon Corp | 300,631 | $17,752 |
| Casdin Capital, LLC | 294,127 | $17,368 |
| IQ EQ FUND MANAGEMENT (IRELAND) Ltd | 264,340 | $15,609 |
| abrdn plc | 263,004 | $15,530 |
| Nuveen, LLC | 248,223 | $14,658 |
| LPL Financial LLC | 241,523 | $14,262 |
| JANE STREET GROUP, LLC | 224,730 | $13,270 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 217,910 | $13 |
| RTW INVESTMENTS, LP | 200,000 | $11,810 |
| CWM, LLC | 194,191 | $11 |
| Swiss National Bank | 182,900 | $10,800 |
| BNP PARIBAS ARBITRAGE, SA | 173,115 | $10,222 |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 172,876 | $10,208 |
| Walleye Capital LLC | 170,696 | $10,080 |
| CAPTRUST FINANCIAL ADVISORS | 169,040 | $9,982 |
| DIMENSIONAL FUND ADVISORS LP | 165,879 | $9,801 |
| ARES MANAGEMENT LLC | 164,383 | $9,707 |
| Vestmark Advisory Solutions, Inc. | 158,131 | $9,338 |
| Jump Financial, LLC | 149,527 | $8,830 |
| GROUP ONE TRADING, L.P. | 147,967 | $8,737 |
| BARCLAYS PLC | 145,742 | $8,606 |
| Contrarius Group Holdings Ltd | 135,026 | $7,973 |
| PEAK6 LLC | 129,677 | $7,657 |
| Walleye Trading LLC | 122,914 | $7,258 |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 121,547 | $7 |
| Kohlberg Kravis Roberts & Co. L.P. | 117,652 | $6,947 |
| RAYMOND JAMES FINANCIAL INC | 117,413 | $6,933 |
| Squarepoint Ops LLC | 113,458 | $6,700 |
| Voleon Capital Management LP | 111,503 | $6,584 |
| H&H International Investment, LLC | 110,000 | $6,496 |
| EXCHANGE TRADED CONCEPTS, LLC | 106,073 | $6,264 |
| Mirae Asset Global Investments Co., Ltd. | 105,314 | $6,219 |
| Summit Financial, LLC | 90,619 | $5,351 |
| DLD Asset Management, LP | 90,270 | $5,330 |
| RENAISSANCE TECHNOLOGIES LLC | 88,800 | $5,244 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 87,504 | $5,167 |
| BALYASNY ASSET MANAGEMENT L.P. | 86,600 | $5,114 |
| Blue Water Life Science Advisors, LP | 86,412 | $5,103 |
| Sculptor Capital LP | 84,000 | $4,960 |
| BLAIR WILLIAM & CO/IL | 81,197 | $4,795 |
| Mitsubishi UFJ Kokusai Asset Management Co., Ltd. | 80,000 | $4,989 |
| BANK OF NOVA SCOTIA | 78,743 | $4,650 |
| FWL INVESTMENT MANAGEMENT, LLC | 76,843 | $4,538 |
| ALLEN OPERATIONS LLC | 76,621 | $4,524 |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 74,092 | $4,375 |
| Spence Asset Management | 72,505 | $4 |
| ROYAL BANK OF CANADA | 72,383 | $4,274 |
| TITLEIST ASSET MANAGEMENT, LLC | 70,568 | $4,167 |
| VAN ECK ASSOCIATES CORP | 69,424 | $4 |
| Mariner, LLC | 68,858 | $4,064 |
| Engineers Gate Manager LP | 66,940 | $3,953 |
| Entropy Technologies, LP | 66,777 | $3,943 |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 65,321 | $3,930 |
| 349 other institutions | 4,060,993 | $221,267 |