| Merck & Co., Inc. | 14,044,943 | $111,798 |
| Lightspeed Management Company, L.L.C. | 8,160,734 | $64,959 |
| ARK Investment Management LLC | 7,879,087 | $62,718 |
| AMERIPRISE FINANCIAL INC | 6,287,151 | $50,046 |
| BlackRock, Inc. | 5,319,508 | $42,343 |
| VANGUARD GROUP INC | 3,253,797 | $25,900 |
| abrdn plc | 3,249,895 | $25,869 |
| AIGH Capital Management LLC | 2,900,000 | $23,084 |
| T. Rowe Price Investment Management, Inc. | 1,938,037 | $15 |
| KENNEDY CAPITAL MANAGEMENT LLC | 1,712,652 | $13,633 |
| Blue Water Life Science Advisors, LP | 1,676,300 | $13,343 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,448,585 | $12 |
| GEODE CAPITAL MANAGEMENT, LLC | 1,297,807 | $10,333 |
| STATE STREET CORP | 1,050,590 | $8,363 |
| DIMENSIONAL FUND ADVISORS LP | 983,174 | $7,826 |
| PFM Health Sciences, LP | 805,817 | $6,414 |
| NEXT CENTURY GROWTH INVESTORS LLC | 624,363 | $4,970 |
| HOWLAND CAPITAL MANAGEMENT LLC | 547,115 | $4,355 |
| Sumitomo Mitsui Trust Holdings, Inc. | 518,441 | $4,127 |
| Nikko Asset Management Americas, Inc. | 518,441 | $4,127 |
| STATE OF MICHIGAN RETIREMENT SYSTEM | 493,798 | $3,931 |
| Portolan Capital Management, LLC | 379,197 | $3,018 |
| FIRST MANHATTAN CO. LLC. | 373,822 | $2,976 |
| NORTHERN TRUST CORP | 354,918 | $2,825 |
| GOLDMAN SACHS GROUP INC | 342,475 | $2,726 |
| Wellington Shields Capital Management, LLC | 340,000 | $2,706 |
| ORACLE INVESTMENT MANAGEMENT INC | 339,343 | $2,701 |
| Nuveen, LLC | 308,680 | $2,457 |
| UBS Group AG | 306,568 | $2,440 |
| Wellington Shields & Co., LLC | 292,489 | $2,328 |
| NANO CAP NEW MILLENNIUM GROWTH FUND L P | 290,000 | $2,308 |
| TD Asset Management Inc | 271,876 | $2,164 |
| IQ EQ FUND MANAGEMENT (IRELAND) Ltd | 267,674 | $2,131 |
| PERKINS CAPITAL MANAGEMENT INC | 239,000 | $1,902 |
| Bruce & Co., Inc. | 233,000 | $1,855 |
| MORGAN STANLEY | 224,563 | $1,788 |
| JANE STREET GROUP, LLC | 171,166 | $1,362 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 158,170 | $1,259 |
| D.A. DAVIDSON & CO. | 145,507 | $1,158 |
| Williams Jones Wealth Management, LLC. | 134,072 | $1,067 |
| LPL Financial LLC | 132,343 | $1,053 |
| Bank of New York Mellon Corp | 122,951 | $979 |
| BARCLAYS PLC | 119,951 | $955 |
| AMERICAN CENTURY COMPANIES INC | 114,001 | $907 |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 108,951 | $867 |
| HRT FINANCIAL LP | 97,772 | $1 |
| RENAISSANCE TECHNOLOGIES LLC | 92,994 | $740 |
| CITADEL ADVISORS LLC | 92,162 | $734 |
| ROYAL BANK OF CANADA | 79,310 | $631 |
| Green Alpha Advisors, LLC | 68,517 | $545 |
| WELLS FARGO & COMPANY/MN | 64,251 | $511 |
| RHUMBLINE ADVISERS | 64,181 | $511 |
| Susquehanna Portfolio Strategies, LLC | 61,844 | $492 |
| BANK OF AMERICA CORP /DE/ | 60,033 | $478 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 56,834 | $452 |
| SEI INVESTMENTS CO | 56,006 | $446 |
| Verition Fund Management LLC | 51,804 | $412 |
| POLEN CAPITAL MANAGEMENT LLC | 50,705 | $404 |
| AlphaCentric Advisors LLC | 47,796 | $380 |
| SG Americas Securities, LLC | 44,678 | $0 |
| Invesco Ltd. | 39,875 | $317 |
| XTX Topco Ltd | 39,412 | $314 |
| Pathstone Holdings, LLC | 39,015 | $311 |
| DEUTSCHE BANK AG\ | 38,827 | $309 |
| TWO SIGMA INVESTMENTS, LP | 32,476 | $259 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 30,967 | $246 |
| Janney Montgomery Scott LLC | 30,000 | $0 |
| ALLIANCEBERNSTEIN L.P. | 28,700 | $228 |
| CITIGROUP INC | 27,608 | $220 |
| JPMORGAN CHASE & CO | 26,716 | $213 |
| INTECH INVESTMENT MANAGEMENT LLC | 20,342 | $162 |
| US BANCORP \DE\ | 20,062 | $160 |
| MetLife Investment Management, LLC | 18,658 | $149 |
| NEW YORK STATE COMMON RETIREMENT FUND | 15,800 | $126 |
| Creative Planning | 15,768 | $126 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 15,745 | $125 |
| AXQ CAPITAL, LP | 14,965 | $119 |
| China Universal Asset Management Co., Ltd. | 14,471 | $115 |
| STIFEL FINANCIAL CORP | 13,933 | $111 |
| GUGGENHEIM CAPITAL LLC | 13,578 | $108 |
| Focus Partners Wealth | 13,527 | $108 |
| BNP PARIBAS ARBITRAGE, SA | 13,456 | $107 |
| ProShare Advisors LLC | 13,081 | $104 |
| Police & Firemen's Retirement System of New Jersey | 12,974 | $103 |
| Scientech Research LLC | 12,402 | $99 |
| Brooklyn Investment Group | 12,045 | $96 |
| RAYMOND JAMES FINANCIAL INC | 11,600 | $92 |
| SIMPLEX TRADING, LLC | 10,923 | $87 |
| DRW Securities, LLC | 10,483 | $83 |
| HSBC HOLDINGS PLC | 10,474 | $84 |
| AQR CAPITAL MANAGEMENT LLC | 10,240 | $82 |
| OSAIC HOLDINGS, INC. | 6,495 | $52 |
| AlphaQuest LLC | 5,007 | $40 |
| Legal & General Group Plc | 4,572 | $36 |
| Mirae Asset Global Investments Co., Ltd. | 4,315 | $34 |
| Ameritas Investment Partners, Inc. | 4,235 | $34 |
| Russell Investments Group, Ltd. | 4,184 | $33 |
| INTERNATIONAL ASSETS INVESTMENT MANAGEMENT, LLC | 3,900 | $31 |
| Caitong International Asset Management Co., Ltd | 3,423 | $27 |
| FMR LLC | 3,391 | $27 |
| 25 other institutions | 18,105 | $147 |