| DEERFIELD MANAGEMENT COMPANY, L.P. | 17,248,450 | $1,735,022 |
| FMR LLC | 10,852,884 | $1,091,692 |
| Paradigm Biocapital Advisors LP | 5,269,433 | $530,052 |
| VANGUARD GROUP INC | 5,244,271 | $527,521 |
| BlackRock, Inc. | 4,805,261 | $483,361 |
| WELLINGTON MANAGEMENT GROUP LLP | 2,461,823 | $247,635 |
| JPMORGAN CHASE & CO | 2,205,251 | $221,826 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,146,938 | $216 |
| RA CAPITAL MANAGEMENT, L.P. | 1,880,057 | $189,115 |
| STATE STREET CORP | 1,864,675 | $187,568 |
| PERCEPTIVE ADVISORS LLC | 1,665,105 | $167,493 |
| Polar Capital Holdings Plc | 1,536,859 | $154,593 |
| JANUS HENDERSON GROUP PLC | 1,499,574 | $150,822 |
| GEODE CAPITAL MANAGEMENT, LLC | 1,238,234 | $124,575 |
| Bellevue Group AG | 1,037,468 | $104,359 |
| BRAIDWELL LP | 821,406 | $82,625 |
| ALLIANCEBERNSTEIN L.P. | 785,445 | $79,008 |
| Fairmount Funds Management LLC | 727,563 | $73,186 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 643,000 | $64,679 |
| Woodline Partners LP | 610,459 | $61,406 |
| GOLDMAN SACHS GROUP INC | 594,459 | $59,797 |
| NORGES BANK | 574,242 | $57,763 |
| AMERIPRISE FINANCIAL INC | 564,298 | $56,763 |
| Commodore Capital LP | 550,000 | $55,325 |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 483,504 | $48,636 |
| Hood River Capital Management LLC | 475,440 | $47,825 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 453,311 | $45,599 |
| Invesco Ltd. | 439,300 | $44,189 |
| FRANKLIN RESOURCES INC | 411,354 | $41,378 |
| NORTHERN TRUST CORP | 410,450 | $41,287 |
| UBS Group AG | 399,053 | $40,141 |
| AMERICAN CENTURY COMPANIES INC | 374,232 | $37,644 |
| T. Rowe Price Investment Management, Inc. | 368,774 | $37 |
| First Turn Management, LLC | 368,697 | $37,087 |
| Candriam S.C.A. | 358,013 | $36,014 |
| Pictet Asset Management Holding SA | 355,681 | $35,778 |
| Affinity Asset Advisors, LLC | 322,633 | $32,454 |
| SILVERARC CAPITAL MANAGEMENT, LLC | 311,430 | $31,327 |
| Tri Locum Partners LP | 307,371 | $30,918 |
| ArrowMark Colorado Holdings LLC | 296,029 | $29,778 |
| LORD, ABBETT & CO. LLC | 281,215 | $28 |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 270,470 | $27,207 |
| Defilade Capital Management, L.P. | 269,043 | $27,063 |
| MORGAN STANLEY | 267,389 | $26,897 |
| CITADEL ADVISORS LLC | 195,156 | $19,631 |
| BANK OF AMERICA CORP /DE/ | 180,369 | $18,143 |
| BNP PARIBAS ARBITRAGE, SA | 174,066 | $17,509 |
| Voya Investment Management LLC | 172,527 | $17,354 |
| abrdn plc | 165,177 | $16,615 |
| Rhenman & Partners Asset Management AB | 163,350 | $16,431 |
| Bank of New York Mellon Corp | 161,599 | $16,255 |
| Nicholas Investment Partners, LP | 160,483 | $16,143 |
| TD Asset Management Inc | 153,360 | $15,426 |
| RAYMOND JAMES FINANCIAL INC | 151,969 | $15,256 |
| BAKER BROS. ADVISORS LP | 143,937 | $14,479 |
| BARCLAYS PLC | 125,328 | $12,607 |
| UBS ASSET MANAGEMENT AMERICAS INC | 124,555 | $12,529 |
| Parkman Healthcare Partners LLC | 118,712 | $11,941 |
| Nuveen, LLC | 107,620 | $10,825 |
| Fisher Asset Management, LLC | 100,706 | $10,130 |
| FRED ALGER MANAGEMENT, LLC | 92,021 | $9,256 |
| Russell Investments Group, Ltd. | 91,195 | $9,173 |
| Point72 Asset Management, L.P. | 88,392 | $8,891 |
| DEUTSCHE BANK AG\ | 83,039 | $8,353 |
| MILLENNIUM MANAGEMENT LLC | 81,866 | $8,235 |
| Swiss National Bank | 78,900 | $7,937 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 78,275 | $7,863 |
| HighVista Strategies LLC | 73,287 | $7,372 |
| Verition Fund Management LLC | 72,015 | $7,244 |
| Burkehill Global Management, LP | 70,000 | $7,041 |
| RHUMBLINE ADVISERS | 63,837 | $6,421 |
| WELLS FARGO & COMPANY/MN | 62,155 | $6,252 |
| Squarepoint Ops LLC | 61,746 | $6,211 |
| BNP Paribas Investment Partners S.A. | 61,130 | $6 |
| Ikarian Capital, LLC | 59,594 | $5,995 |
| Ensign Peak Advisors, Inc | 54,202 | $5,452 |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 46,690 | $4,697 |
| Vestal Point Capital, LP | 46,000 | $4,627 |
| Rafferty Asset Management, LLC | 45,945 | $4,622 |
| Connor, Clark & Lunn Investment Management Ltd. | 42,360 | $4,261 |
| Legal & General Group Plc | 41,651 | $4,190 |
| Granahan Investment Management, LLC | 40,211 | $4,045 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 38,284 | $3,851 |
| NEOS Investment Management LLC | 37,003 | $3,722 |
| TEMA ETFS LLC | 36,458 | $3,667 |
| CITIGROUP INC | 35,831 | $3,604 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 32,547 | $3,273 |
| NEW YORK STATE COMMON RETIREMENT FUND | 32,460 | $3,265 |
| Creative Planning | 29,940 | $3,012 |
| Jump Financial, LLC | 27,955 | $2,812 |
| MetLife Investment Management, LLC | 27,631 | $2,779 |
| Alyeska Investment Group, L.P. | 25,533 | $2,568 |
| AQR CAPITAL MANAGEMENT LLC | 25,520 | $2,567 |
| STATE OF WISCONSIN INVESTMENT BOARD | 25,197 | $2,535 |
| SEVEN GRAND MANAGERS, LLC | 25,000 | $2,515 |
| MARSHALL WACE, LLP | 23,930 | $2,407 |
| SEI INVESTMENTS CO | 23,160 | $2,329 |
| FIRST TRUST ADVISORS LP | 22,165 | $2,230 |
| TANG CAPITAL MANAGEMENT LLC | 21,880 | $2,201 |
| Legato Capital Management LLC | 21,732 | $2,186 |
| 135 other institutions | 562,382 | $49,431 |