| GILEAD SCIENCES, INC. | 31,424,760 | $748,852 |
| BlackRock, Inc. | 14,997,891 | $357,400 |
| VANGUARD GROUP INC | 7,962,874 | $189,755 |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 5,188,858 | $123,650 |
| WELLINGTON MANAGEMENT GROUP LLP | 5,184,509 | $123,547 |
| STATE STREET CORP | 4,576,969 | $109,069 |
| Woodline Partners LP | 3,769,788 | $89,834 |
| MARSHALL WACE, LLP | 3,387,794 | $80,731 |
| Point72 Asset Management, L.P. | 3,280,000 | $78,162 |
| Siren, L.L.C. | 3,007,077 | $71,659 |
| Fisher Asset Management, LLC | 1,949,788 | $46,463 |
| GEODE CAPITAL MANAGEMENT, LLC | 1,907,345 | $45,459 |
| BNP Paribas Investment Partners S.A. | 1,687,374 | $40 |
| SAMLYN CAPITAL, LLC | 1,604,270 | $38,230 |
| DIMENSIONAL FUND ADVISORS LP | 1,524,157 | $36,317 |
| TORONTO DOMINION BANK | 1,484,699 | $35,380 |
| MORGAN STANLEY | 1,210,754 | $28,852 |
| GOLDMAN SACHS GROUP INC | 1,168,437 | $27,844 |
| FMR LLC | 1,135,178 | $27,051 |
| BARCLAYS PLC | 1,112,258 | $26,505 |
| Sofinnova Investments, Inc. | 1,096,705 | $26,134 |
| BANK OF AMERICA CORP /DE/ | 1,000,818 | $23,849 |
| Parkman Healthcare Partners LLC | 968,602 | $23,082 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 968,241 | $23,073 |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 929,981 | $22,161 |
| Trails Edge Capital Partners, LP | 916,313 | $21,836 |
| FRANKLIN RESOURCES INC | 853,491 | $20,339 |
| BALYASNY ASSET MANAGEMENT L.P. | 815,561 | $19,435 |
| NORTHERN TRUST CORP | 794,798 | $18,940 |
| Candriam S.C.A. | 790,613 | $18,841 |
| Caption Management, LLC | 767,698 | $18,294 |
| Soleus Capital Management, L.P. | 711,983 | $16,967 |
| First Turn Management, LLC | 565,142 | $13,467 |
| Decheng Capital LLC | 541,559 | $12,905 |
| Bank of New York Mellon Corp | 504,462 | $12,021 |
| DAFNA Capital Management LLC | 431,329 | $10,279 |
| BNP PARIBAS ARBITRAGE, SA | 424,071 | $10,106 |
| Invesco Ltd. | 414,365 | $9,874 |
| UBS Group AG | 411,259 | $9,800 |
| PRINCIPAL FINANCIAL GROUP INC | 407,513 | $9,711 |
| PDT Partners, LLC | 388,338 | $9,254 |
| abrdn plc | 384,601 | $9,165 |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | 379,100 | $9,034 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 341,865 | $8,147 |
| Affinity Asset Advisors, LLC | 300,000 | $7,149 |
| Public Sector Pension Investment Board | 295,426 | $7,040 |
| BAKER BROS. ADVISORS LP | 270,000 | $6,434 |
| Hudson Bay Capital Management LP | 240,000 | $5,719 |
| Susquehanna Portfolio Strategies, LLC | 239,966 | $5,718 |
| RHUMBLINE ADVISERS | 227,146 | $5,413 |
| AMERIPRISE FINANCIAL INC | 225,913 | $5,384 |
| TUDOR INVESTMENT CORP ET AL | 208,639 | $4,972 |
| Legal & General Group Plc | 205,203 | $4,890 |
| Nicholas Investment Partners, LP | 204,338 | $4,869 |
| Connor, Clark & Lunn Investment Management Ltd. | 203,268 | $4,844 |
| Rock Springs Capital Management LP | 180,000 | $4,289 |
| Patient Square Capital LP | 170,000 | $4,051 |
| Granahan Investment Management, LLC | 169,940 | $4,050 |
| MILLENNIUM MANAGEMENT LLC | 168,876 | $4,024 |
| Swiss National Bank | 167,996 | $4,003 |
| UBS ASSET MANAGEMENT AMERICAS INC | 144,093 | $3,434 |
| Alyeska Investment Group, L.P. | 142,518 | $3,396 |
| Nuveen, LLC | 141,600 | $3,374 |
| TWO SIGMA INVESTMENTS, LP | 139,631 | $3,327 |
| Russell Investments Group, Ltd. | 136,121 | $3,244 |
| PLATINUM INVESTMENT MANAGEMENT LTD | 134,217 | $3,198 |
| ALLIANCEBERNSTEIN L.P. | 133,098 | $3,172 |
| AMERICAN CENTURY COMPANIES INC | 128,947 | $3,073 |
| Knott David M Jr | 121,241 | $2,889 |
| CITADEL ADVISORS LLC | 104,701 | $2,495 |
| LMR Partners LLP | 100,000 | $2,383 |
| WELLS FARGO & COMPANY/MN | 99,318 | $2,367 |
| Schonfeld Strategic Advisors LLC | 97,283 | $2,318 |
| Rafferty Asset Management, LLC | 92,929 | $2,214 |
| NEW YORK STATE TEACHERS RETIREMENT SYSTEM | 92,431 | $2 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 90,666 | $2,161 |
| Parallel Advisors, LLC | 86,557 | $2,063 |
| AQR CAPITAL MANAGEMENT LLC | 86,207 | $2,054 |
| D. E. Shaw & Co., Inc. | 85,570 | $2,039 |
| Thrivent Financial for Lutherans | 80,393 | $2 |
| PRUDENTIAL FINANCIAL INC | 79,458 | $1,893 |
| GREAT WEST LIFE ASSURANCE CO /CAN/ | 73,862 | $2 |
| JPMORGAN CHASE & CO | 72,755 | $1,734 |
| DEUTSCHE BANK AG\ | 62,652 | $1,493 |
| WINTON GROUP Ltd | 62,251 | $1,483 |
| DARK FOREST CAPITAL MANAGEMENT LP | 60,614 | $1,444 |
| STATE OF WISCONSIN INVESTMENT BOARD | 58,835 | $1,402 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 58,649 | $1 |
| SECTORAL ASSET MANAGEMENT INC | 56,945 | $1,357 |
| Fort Baker Capital Management LP | 52,523 | $1,252 |
| Burkehill Global Management, LP | 50,000 | $1,192 |
| JANE STREET GROUP, LLC | 46,505 | $1,108 |
| SG Americas Securities, LLC | 45,488 | $1 |
| FRED ALGER MANAGEMENT, LLC | 44,758 | $1,067 |
| State of Alaska, Department of Revenue | 43,451 | $1 |
| MetLife Investment Management, LLC | 43,434 | $1,035 |
| NEW YORK STATE COMMON RETIREMENT FUND | 43,002 | $1,025 |
| JANUS HENDERSON GROUP PLC | 42,338 | $1,009 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 41,993 | $1,001 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 41,955 | $997 |
| 106 other institutions | 1,228,980 | $26,696 |