| VANGUARD GROUP INC | 12,160,768 | $1,242,101 |
| BlackRock, Inc. | 11,317,714 | $1,155,991 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 5,636,078 | $576 |
| Invesco Ltd. | 5,315,934 | $542,969 |
| BAILLIE GIFFORD & CO | 4,890,026 | $499,467 |
| Capital International Investors | 3,528,656 | $360,417 |
| FRANKLIN RESOURCES INC | 3,361,547 | $343,348 |
| GEODE CAPITAL MANAGEMENT, LLC | 3,213,657 | $328,297 |
| Deep Track Capital, LP | 2,800,000 | $285,992 |
| STATE STREET CORP | 2,795,727 | $285,556 |
| GOLDMAN SACHS GROUP INC | 2,627,709 | $268,394 |
| EVENTIDE ASSET MANAGEMENT, LLC | 2,511,091 | $256,455 |
| FULLER & THALER ASSET MANAGEMENT, INC. | 2,441,730 | $249,398 |
| FMR LLC | 2,396,433 | $244,772 |
| TWO SIGMA ADVISERS, LP | 2,382,300 | $243,328 |
| TWO SIGMA INVESTMENTS, LP | 2,171,903 | $221,838 |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 2,143,193 | $218,906 |
| FEDERATED HERMES, INC. | 2,031,562 | $207,504 |
| LORD, ABBETT & CO. LLC | 1,988,983 | $203 |
| UBS ASSET MANAGEMENT AMERICAS INC | 1,915,581 | $195,657 |
| ALLIANCEBERNSTEIN L.P. | 1,901,308 | $194,200 |
| UBS Group AG | 1,710,169 | $174,677 |
| Point72 Asset Management, L.P. | 1,499,169 | $153,125 |
| RTW INVESTMENTS, LP | 1,481,033 | $151,273 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,457,676 | $148,887 |
| Bank of New York Mellon Corp | 1,366,157 | $139,539 |
| Alyeska Investment Group, L.P. | 1,343,654 | $137,241 |
| NORGES BANK | 1,258,072 | $128,499 |
| JENNISON ASSOCIATES LLC | 1,170,337 | $119,538 |
| MORGAN STANLEY | 1,154,299 | $117,900 |
| NORTHERN TRUST CORP | 1,102,791 | $112,639 |
| Erste Asset Management GmbH | 1,045,917 | $106,781 |
| Temasek Holdings (Private) Ltd | 1,044,097 | $106,644 |
| BANK OF AMERICA CORP /DE/ | 1,017,646 | $103,942 |
| Hood River Capital Management LLC | 978,515 | $99,946 |
| CADIAN CAPITAL MANAGEMENT, LP | 922,628 | $94,237 |
| EMERALD ADVISERS, LLC | 861,824 | $88,027 |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC | 851,958 | $87,019 |
| AMERIPRISE FINANCIAL INC | 762,595 | $77,890 |
| ARK Investment Management LLC | 691,647 | $70,645 |
| Sumitomo Mitsui Trust Holdings, Inc. | 640,505 | $65,421 |
| Nikko Asset Management Americas, Inc. | 640,295 | $65,381 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 635,935 | $64,809 |
| BNP PARIBAS ARBITRAGE, SA | 624,776 | $63,815 |
| D. E. Shaw & Co., Inc. | 623,057 | $63,639 |
| Allspring Global Investments Holdings, LLC | 618,599 | $62,936 |
| RENAISSANCE TECHNOLOGIES LLC | 602,300 | $61,519 |
| FRED ALGER MANAGEMENT, LLC | 589,656 | $60,227 |
| MILLENNIUM MANAGEMENT LLC | 583,807 | $59,630 |
| CITADEL ADVISORS LLC | 564,342 | $57,642 |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 539,190 | $55,073 |
| EMERALD MUTUAL FUND ADVISERS TRUST | 523,932 | $53,514 |
| JANE STREET GROUP, LLC | 513,620 | $52,461 |
| BALYASNY ASSET MANAGEMENT L.P. | 505,608 | $51,643 |
| Aristotle Atlantic Partners, LLC | 494,386 | $50,497 |
| Nuveen, LLC | 473,451 | $48,358 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 464,905 | $47,485 |
| JUPITER ASSET MANAGEMENT LTD | 421,328 | $43,034 |
| WELLINGTON MANAGEMENT GROUP LLP | 406,519 | $41,522 |
| Casdin Capital, LLC | 380,000 | $38,813 |
| VICTORY CAPITAL MANAGEMENT INC | 377,045 | $38,511 |
| Blue Water Life Science Advisors, LP | 355,047 | $36,265 |
| DEUTSCHE BANK AG\ | 336,428 | $34,363 |
| BARCLAYS PLC | 336,274 | $34,347 |
| PBU - The Pension Fund of Early Childhood & Youth Educators | 335,854 | $34,304 |
| Voya Investment Management LLC | 330,429 | $33,750 |
| RAYMOND JAMES FINANCIAL INC | 328,632 | $33,238 |
| DIMENSIONAL FUND ADVISORS LP | 306,553 | $31,301 |
| Man Group plc | 295,804 | $30,213 |
| First Light Asset Management, LLC | 294,751 | $30,106 |
| Artisan Partners Limited Partnership | 290,352 | $29,657 |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 287,454 | $29,214 |
| Eagle Health Investments LP | 284,100 | $29,018 |
| Styrax Capital, LP | 281,589 | $28,762 |
| Trexquant Investment LP | 274,039 | $27,990 |
| First Turn Management, LLC | 271,685 | $27,750 |
| JPMORGAN CHASE & CO | 271,039 | $27,684 |
| Connor, Clark & Lunn Investment Management Ltd. | 266,492 | $27,219 |
| SEI INVESTMENTS CO | 261,942 | $26,754 |
| Walleye Capital LLC | 254,302 | $25,974 |
| SEGALL BRYANT & HAMILL, LLC | 244,266 | $24,949 |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 237,481 | $24,256 |
| Sicart Associates LLC | 228,203 | $23,309 |
| Swiss National Bank | 221,300 | $22,604 |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 215,092 | $21,969 |
| WELLS FARGO & COMPANY/MN | 214,177 | $21,876 |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | 212,947 | $21,750 |
| Russell Investments Group, Ltd. | 211,392 | $21,592 |
| Rathbones Group PLC | 205,113 | $20,950 |
| AXIOM INVESTORS LLC /DE | 203,642 | $20,800 |
| CITIGROUP INC | 188,888 | $19,293 |
| TD Asset Management Inc | 181,048 | $18,492 |
| FIRST TRUST ADVISORS LP | 179,731 | $18,358 |
| MARSHALL WACE, LLP | 171,206 | $17,487 |
| Pictet Asset Management Holding SA | 166,384 | $16,882 |
| CASTLEARK MANAGEMENT LLC | 165,043 | $16,857 |
| PERCEPTIVE ADVISORS LLC | 160,000 | $16,342 |
| PICTON MAHONEY ASSET MANAGEMENT | 159,029 | $16,243 |
| Granite Investment Partners, LLC | 158,199 | $16,158 |
| Polar Capital Holdings Plc | 157,485 | $16,086 |
| 390 other institutions | 9,044,107 | $843,958 |