| BlackRock, Inc. | 7,322,501 | $86,845 |
| VANGUARD GROUP INC | 7,229,603 | $85,743 |
| D. E. Shaw & Co., Inc. | 3,689,201 | $43,754 |
| Pfizer Inc | 3,457,815 | $41,010 |
| TCG Crossover Management, LLC | 2,666,216 | $31,621 |
| Point72 Asset Management, L.P. | 2,315,361 | $27,460 |
| STATE STREET CORP | 1,843,409 | $21,863 |
| ARMISTICE CAPITAL, LLC | 1,800,000 | $21,348 |
| GEODE CAPITAL MANAGEMENT, LLC | 1,623,489 | $19,259 |
| Qube Research & Technologies Ltd | 1,324,740 | $15,711 |
| MILLENNIUM MANAGEMENT LLC | 1,259,441 | $14,937 |
| ACADIAN ASSET MANAGEMENT LLC | 1,187,029 | $14 |
| GOLDMAN SACHS GROUP INC | 1,116,150 | $13,238 |
| FEDERATED HERMES, INC. | 1,094,999 | $12,987 |
| TWO SIGMA INVESTMENTS, LP | 992,463 | $11,771 |
| MORGAN STANLEY | 810,072 | $9,607 |
| TWO SIGMA ADVISERS, LP | 619,900 | $7,352 |
| TANG CAPITAL MANAGEMENT LLC | 569,698 | $6,757 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 547,476 | $6,493 |
| NORTHERN TRUST CORP | 547,472 | $6,493 |
| Nextech Invest, Ltd. | 539,394 | $6,397 |
| NORDEA INVESTMENT MANAGEMENT AB | 495,477 | $5,891 |
| DIMENSIONAL FUND ADVISORS LP | 472,420 | $5,602 |
| CAXTON ASSOCIATES LLP | 454,517 | $5,391 |
| Arbiter Partners Capital Management LLC | 452,789 | $5,370 |
| KENNEDY CAPITAL MANAGEMENT LLC | 442,778 | $5,251 |
| CITADEL ADVISORS LLC | 413,646 | $4,906 |
| Rangeley Capital, LLC | 395,800 | $4,694 |
| Trexquant Investment LP | 394,737 | $4,682 |
| Ikarian Capital, LLC | 358,257 | $4,249 |
| MARSHALL WACE, LLP | 332,535 | $3,944 |
| AQR CAPITAL MANAGEMENT LLC | 318,985 | $3,783 |
| JANE STREET GROUP, LLC | 309,113 | $3,666 |
| Invesco Ltd. | 302,100 | $3,583 |
| Susquehanna Portfolio Strategies, LLC | 301,245 | $3,573 |
| Nantahala Capital Management, LLC | 300,000 | $3,558 |
| WASATCH ADVISORS LP | 269,149 | $3,192 |
| Bank of New York Mellon Corp | 268,583 | $3,185 |
| BALYASNY ASSET MANAGEMENT L.P. | 261,756 | $3,104 |
| HRT FINANCIAL LP | 260,970 | $3 |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 252,294 | $2,992 |
| FRANKLIN RESOURCES INC | 203,947 | $2,419 |
| ALGERT GLOBAL LLC | 195,036 | $2 |
| ExodusPoint Capital Management, LP | 188,908 | $2,240 |
| Jump Financial, LLC | 188,271 | $2,233 |
| Voleon Capital Management LP | 184,977 | $2,194 |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | 180,000 | $2,135 |
| BARCLAYS PLC | 168,407 | $1,997 |
| UBS Group AG | 166,917 | $1,980 |
| Brummer Multi-Strategy AB | 166,342 | $1,973 |
| BANK OF AMERICA CORP /DE/ | 154,309 | $1,830 |
| ZACKS INVESTMENT MANAGEMENT | 148,704 | $1,764 |
| DEUTSCHE BANK AG\ | 145,284 | $1,723 |
| Nuveen, LLC | 142,782 | $1,693 |
| Y-Intercept (Hong Kong) Ltd | 124,835 | $1,481 |
| UBS ASSET MANAGEMENT AMERICAS INC | 124,321 | $1,474 |
| Swiss National Bank | 123,100 | $1,460 |
| LPL Financial LLC | 111,239 | $1,319 |
| HUSSMAN STRATEGIC ADVISORS, INC. | 105,000 | $1,245 |
| Connor, Clark & Lunn Investment Management Ltd. | 101,838 | $1,208 |
| WELLS FARGO & COMPANY/MN | 101,516 | $1,204 |
| Man Group plc | 99,886 | $1,185 |
| Verition Fund Management LLC | 91,999 | $1,091 |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 91,019 | $1,079 |
| RHUMBLINE ADVISERS | 87,196 | $1,034 |
| Headlands Technologies LLC | 86,211 | $1,022 |
| BOOTHBAY FUND MANAGEMENT, LLC | 82,482 | $978 |
| FOX RUN MANAGEMENT, L.L.C. | 82,127 | $974 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 81,565 | $1 |
| SG Americas Securities, LLC | 78,164 | $1 |
| HSBC HOLDINGS PLC | 73,779 | $876 |
| ALLIANCEBERNSTEIN L.P. | 73,720 | $874 |
| PLATINUM INVESTMENT MANAGEMENT LTD | 72,527 | $860 |
| VIRGINIA RETIREMENT SYSTEMS ET AL | 70,650 | $838 |
| Monaco Asset Management SAM | 70,253 | $833 |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 68,057 | $807 |
| Quantinno Capital Management LP | 66,245 | $786 |
| Legal & General Group Plc | 60,526 | $718 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 60,523 | $718 |
| ADAR1 Capital Management, LLC | 58,091 | $689 |
| Engineers Gate Manager LP | 58,071 | $689 |
| Vienna Powszechne Towarzystwo Emerytalne S.A. Vienna Insurance Group | 57,500 | $682 |
| Creative Planning | 56,927 | $675 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 56,826 | $674 |
| AMERICAN CENTURY COMPANIES INC | 53,499 | $634 |
| NEOS Investment Management LLC | 49,531 | $587 |
| TEMA ETFS LLC | 48,801 | $579 |
| Brevan Howard Capital Management LP | 47,850 | $568 |
| Yelin Lapidot Holdings Management Ltd. | 46,665 | $553 |
| Allspring Global Investments Holdings, LLC | 46,574 | $552 |
| CITIGROUP INC | 42,306 | $502 |
| GSA CAPITAL PARTNERS LLP | 42,098 | $0 |
| DekaBank Deutsche Girozentrale | 42,000 | $2 |
| AlphaQuest LLC | 41,456 | $492 |
| Quinn Opportunity Partners LLC | 41,263 | $489 |
| AMERIPRISE FINANCIAL INC | 37,871 | $449 |
| TUDOR INVESTMENT CORP ET AL | 36,976 | $439 |
| Russell Investments Group, Ltd. | 34,636 | $411 |
| MetLife Investment Management, LLC | 33,810 | $401 |
| Numerai GP LLC | 32,348 | $384 |
| 103 other institutions | 916,003 | $10,449 |