| VANGUARD GROUP INC | 16,862,691 | $1,289,827 |
| BlackRock, Inc. | 14,549,529 | $1,112,893 |
| VIKING GLOBAL INVESTORS LP | 14,393,934 | $1,100,992 |
| Kohlberg Kravis Roberts & Co. L.P. | 13,260,971 | $1,014,332 |
| JANUS HENDERSON GROUP PLC | 11,000,457 | $841,349 |
| FARALLON CAPITAL MANAGEMENT LLC | 8,998,463 | $688,292 |
| Aisling Capital Management LP | 5,089,611 | $389,304 |
| STATE STREET CORP | 4,962,866 | $379,610 |
| Invesco Ltd. | 4,831,305 | $369,547 |
| GEODE CAPITAL MANAGEMENT, LLC | 4,412,523 | $344,689 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,828,746 | $293 |
| Frazier Life Sciences Management, L.P. | 3,545,557 | $271,200 |
| Brooklands Fund Management Ltd | 2,750,000 | $2,810 |
| FMR LLC | 2,390,362 | $182,839 |
| WELLINGTON MANAGEMENT GROUP LLP | 2,348,731 | $179,654 |
| D. E. Shaw & Co., Inc. | 2,214,031 | $169,351 |
| FRANKLIN RESOURCES INC | 2,164,928 | $165,595 |
| ALLIANCEBERNSTEIN L.P. | 2,050,746 | $156,862 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 1,975,315 | $151,012 |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,964,419 | $150,258 |
| TWO SIGMA INVESTMENTS, LP | 1,947,047 | $148,930 |
| Capital Research Global Investors | 1,934,698 | $147,985 |
| UBS Group AG | 1,875,665 | $143,470 |
| SC US (TTGP), LTD. | 1,860,364 | $142,299 |
| GOLDMAN SACHS GROUP INC | 1,782,833 | $136,369 |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | 1,725,266 | $131,966 |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,680,972 | $128,578 |
| BNP PARIBAS ARBITRAGE, SA | 1,592,660 | $121,823 |
| NORGES BANK | 1,527,028 | $116,802 |
| Laurion Capital Management LP | 1,402,150 | $107,250 |
| TWO SIGMA ADVISERS, LP | 1,401,035 | $107,165 |
| MORGAN STANLEY | 1,399,809 | $107,071 |
| NORTHERN TRUST CORP | 1,346,754 | $103,013 |
| PRINCIPAL FINANCIAL GROUP INC | 1,314,303 | $100,531 |
| Polar Capital Holdings Plc | 1,299,346 | $99,387 |
| Pictet Asset Management Holding SA | 1,270,290 | $96,956 |
| Ensign Peak Advisors, Inc | 1,263,484 | $96,644 |
| Hood River Capital Management LLC | 1,255,185 | $96,009 |
| Cormorant Asset Management, LP | 1,200,000 | $91,788 |
| AMERICAN CENTURY COMPANIES INC | 1,106,820 | $84,661 |
| BANK OF AMERICA CORP /DE/ | 1,078,048 | $82,460 |
| Allspring Global Investments Holdings, LLC | 994,220 | $77,783 |
| JPMORGAN CHASE & CO | 858,968 | $65,702 |
| AMERIPRISE FINANCIAL INC | 841,536 | $64,369 |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 826,131 | $63,191 |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC | 813,794 | $62,247 |
| Deep Track Capital, LP | 810,142 | $61,968 |
| LORD, ABBETT & CO. LLC | 781,345 | $60 |
| PANAGORA ASSET MANAGEMENT INC | 738,843 | $56,514 |
| Sofinnova Investments, Inc. | 720,448 | $55,107 |
| CITIGROUP INC | 700,251 | $53,562 |
| CITADEL ADVISORS LLC | 698,182 | $53,404 |
| Paradigm Biocapital Advisors LP | 684,277 | $52,340 |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 638,883 | $48,868 |
| GW&K Investment Management, LLC | 626,122 | $48 |
| BARCLAYS PLC | 622,575 | $47,621 |
| Bank of New York Mellon Corp | 596,403 | $45,619 |
| First Turn Management, LLC | 595,473 | $45,548 |
| FEDERATED HERMES, INC. | 586,795 | $44,884 |
| Voya Investment Management LLC | 583,361 | $44,621 |
| PRIMECAP MANAGEMENT CO/CA/ | 569,680 | $43,575 |
| EMERALD ADVISERS, LLC | 535,764 | $40,981 |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 508,134 | $38,867 |
| Clearbridge Investments, LLC | 498,329 | $38,117 |
| Nuveen, LLC | 494,785 | $37,846 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 487,376 | $37,279 |
| GILDER GAGNON HOWE & CO LLC | 457,977 | $35,031 |
| UBS ASSET MANAGEMENT AMERICAS INC | 451,016 | $34,498 |
| Russell Investments Group, Ltd. | 415,156 | $31,755 |
| DIMENSIONAL FUND ADVISORS LP | 382,569 | $29,252 |
| DEUTSCHE BANK AG\ | 381,063 | $29,148 |
| EVENTIDE ASSET MANAGEMENT, LLC | 362,130 | $27,699 |
| JANE STREET GROUP, LLC | 341,795 | $26,144 |
| ALGERT GLOBAL LLC | 341,048 | $26 |
| Legal & General Group Plc | 334,731 | $25,604 |
| Affinity Asset Advisors, LLC | 320,000 | $24,477 |
| EMERALD MUTUAL FUND ADVISERS TRUST | 316,784 | $24,231 |
| NOMURA HOLDINGS INC | 309,930 | $23,707 |
| PFM Health Sciences, LP | 306,506 | $23,445 |
| Woodline Partners LP | 300,912 | $23,017 |
| Nicholas Investment Partners, LP | 284,682 | $21,775 |
| Swiss National Bank | 282,600 | $21,616 |
| FIRST TRUST ADVISORS LP | 281,686 | $21,546 |
| Artisan Partners Limited Partnership | 279,067 | $21,346 |
| Candriam S.C.A. | 278,888 | $21,333 |
| VICTORY CAPITAL MANAGEMENT INC | 277,081 | $21,194 |
| Squarepoint Ops LLC | 268,899 | $20,568 |
| Eagle Health Investments LP | 259,300 | $19,834 |
| OSAIC HOLDINGS, INC. | 252,145 | $19,286 |
| Skandinaviska Enskilda Banken AB (publ) | 237,791 | $18,189 |
| BALYASNY ASSET MANAGEMENT L.P. | 234,389 | $17,928 |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 233,936 | $17,894 |
| ROYCE & ASSOCIATES LP | 232,923 | $17,816 |
| Fisher Asset Management, LLC | 232,401 | $17,776 |
| WELLS FARGO & COMPANY/MN | 232,262 | $17,766 |
| SEI INVESTMENTS CO | 224,866 | $17,200 |
| NEUBERGER BERMAN GROUP LLC | 221,245 | $16,923 |
| RHUMBLINE ADVISERS | 213,471 | $16,328 |
| ADAR1 Capital Management, LLC | 213,414 | $16,324 |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 207,883 | $15,901 |
| 328 other institutions | 9,355,065 | $675,271 |